Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jourdin R. C. Rouaen"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Manuela Curcio, Giuseppe Cirillo, Jourdin R. C. Rouaen, Federica Saletta, Fiore Pasquale Nicoletta, Orazio Vittorio, Francesca Iemma
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1183 (2020)
Targeted drug delivery systems represent valuable tools to enhance the accumulation of therapeutics in the brain. Here, the presence of the blood brain barrier strongly hinders the passage of foreign substances, often limiting the effectiveness of ph
Externí odkaz:
https://doaj.org/article/ae0c1c0f45c64a6cbb2a1acd45134d22
Autor:
Holly Holliday, Anahid Ehteda, Aaminah Khan, Brian Krug, Jourdin R C Rouaen, Nisitha Jayatilleke, Chelsea Mayoh, Orazio Vittorio, Nada Jabado, Maria Tsoli, David S Ziegler
Publikováno v:
Neuro-Oncology. 24:i18-i18
Effective treatments are urgently needed for the incurable paediatric brainstem tumour Diffuse Midline Glioma (DMG). Most DMGs contain Histone H3 mutations (H3K27M), which produce extensive epigenetic dysregulation by inhibiting EZH2-mediated trimeth
Autor:
Orazio Vittorio, Daniele Mercatelli, Federico M. Giorgi, David S. Ziegler, Federica Saletta, Filip Michniewicz, Toby Trahair, Jourdin R. C. Rouaen, Rehana V. Hewavisenti, Giuseppe Cirillo
Copper is an essential transition metal frequently increased in cancer known to strongly influence essential cellular processes. Targeted therapy protocols utilizing both novel and repurposed drug agents initially demonstrate strong efficacy, before
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00309c777502ec7596457ff88496312d
http://hdl.handle.net/11585/831844
http://hdl.handle.net/11585/831844
Autor:
Swapna Joshi, Murray D. Norris, Sandy Simon, Orazio Vittorio, Sylvie Shen, Andrei V. Gudkov, Ornella Tolhurst, Anahid Ehteda, Caitlin Ung, Jourdin R. C. Rouaen, Ruby Pandher, Aaminah Khan, Michelle Haber, Elisha Hayden, Laura Franshaw, Rebecca Lehmann, Chelsea Mayoh, Yujie Tang, Katerina Gurova, David S. Ziegler, Maria Tsoli, Federico M. Giorgi, Anjana Gopalakrishnan, Jie Liu, Chi Nam Ignatius Pang, Anne Kankean, Peter Trebilcock
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994-(2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbee79680e90f0fba780fc68415fa1d
https://hdl.handle.net/11585/831846
https://hdl.handle.net/11585/831846
Autor:
Francesca Iemma, Fiore Pasquale Nicoletta, Manuela Curcio, Federica Saletta, Jourdin R. C. Rouaen, Giuseppe Cirillo, Orazio Vittorio
Publikováno v:
Pharmaceutics, Vol 12, Iss 1183, p 1183 (2020)
Pharmaceutics
Pharmaceutics
Targeted drug delivery systems represent valuable tools to enhance the accumulation of therapeutics in the brain. Here, the presence of the blood brain barrier strongly hinders the passage of foreign substances, often limiting the effectiveness of ph
Autor:
Yujie Tang, Rebecca Lehmann, Elisha Hayden, Murray D. Norris, Jie Liu, Anahid Ehteda, Aaminah Khan, Chi Nam Ignatius Pang, Michelle Haber, Sylvie Shen, Anjana Gopalakrishnan, Caitlin Ung, David S. Ziegler, Andrei V. Gudkov, Ruby Pandher, Orazio Vittorio, Chelsea Mayoh, Maria Tsoli, Anne Kankean, Federico M. Giorgi, Jourdin R. C. Rouaen, Laura Franshaw, Katerina Gurova, Peter Trebilcock, Sandy Simon
Publikováno v:
Neuro-Oncology
DIPG is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity against DIPG neur
Autor:
Michelle Haber, Ornella Tolhurst, Murray D. Norris, Aaminah Khan, Sylvie Shen, Maria Tsoli, Jie Liu, Caitlin Ung, Orazio Vittorio, Yujie Tang, Andrei V. Gudkov, Jourdin R. C. Rouaen, Peter Trebilcock, Federico M. Giorgi, Chi Nam Ignatius Pang, Anjana Gopalakrishnan, Elisha Hayden, Swapna Joshi, Sandy Simon, David S. Ziegler, Chelsea Mayoh, Anahid Ehteda, Anne Kankean, Katerina Gurova, Ruby Pandher, Laura Franshaw
Publikováno v:
SSRN Electronic Journal.
Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. A high throughput drug screen of 3600 pharmaceutical compounds found that anti-malarials, including quinacrine had poten
Autor:
Chelsea Mayoh, Aria Ahmed-Cox, Kathleen Kimpton, Federica Saletta, Emanuele Valli, Joseph A. Trapani, Daniele Mercatelli, Sylvie Shen, Paul A. Beavis, Michelle Haber, Jourdin R. C. Rouaen, Jayne Murray, Giuseppe Cirillo, Luigi Lerra, Orazio Vittorio, Florida Voli, Federico M. Giorgi, Maria Kavallaris
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d3b95b70cadf09403193149f3c1dd
http://hdl.handle.net/11585/777521
http://hdl.handle.net/11585/777521