Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joung-Sun Park"'
Autor:
Joung-Sun Park, Yung-Jin Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3497 (2020)
Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restricti
Externí odkaz:
https://doaj.org/article/964ae643bc70419eb0c879cc5209c621
Autor:
Mi-Ae Yoo, Ho-Jun Jeon, Jung-Hoon Pyo, Kyu Heo, Young-Shin Kim, Joung-Sun Park, Masamitsu Yamaguchi, Joong-Gook Kim
Publikováno v:
Mechanisms of Ageing and Development. 173:50-60
Chromatin change is one of the crucial causes of aging. Specifically, maintenance of heterochromatin stability is critical for cellular integrity, and its loss induces genomic instability and cellular aging. However, the causes and effects of heteroc
Publikováno v:
Oncotarget
The intestine is a high cellular turnover tissue largely dependent on the regenerative function of stem cell throughout life, and a signaling center for the health and viability of organisms. Therefore, better understanding of the mechanisms underlyi
Publikováno v:
Aging. 10:322-338
Stem cell dysfunction is closely linked to tissue and organismal aging and age-related diseases, and heavily influenced by the niche cells' environment. The DNA damage response (DDR) is a key pathway for tissue degeneration and organismal aging; howe
Publikováno v:
Biochemical and Biophysical Research Communications. 498:18-24
Age-related changes of adult stem cell are crucial for tissue aging and age-related diseases. Thus, clarifying mechanisms to prevent adult stem cell aging is indispensable for healthy aging. Metformin, a drug for type 2 diabetes, has been highlighted
Publikováno v:
Aging (Albany NY)
Stem cell dysfunction is closely linked to tissue and organismal aging and age-related diseases, and heavily influenced by the niche cells’ environment. The DNA damage response (DDR) is a key pathway for tissue degeneration and organismal aging; ho
Autor:
Young-Shin Kim, Mi-Ae Yoo, Jung Hoon Pyo, Joung Sun Park, Robert Arking, Ho-Jun Jeon, Hyun Jin Na
Publikováno v:
Mechanisms of Ageing and Development. 149:8-18
We delineated the mechanism regulating the inhibition of centrosome amplification by metformin in Drosophila intestinal stem cells (ISCs). Age-related changes in tissue-resident stem cells may be closely associated with tissue aging and age-related d
Publikováno v:
Aging (Albany NY)
The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related facto
Autor:
Hideki Yoshida, Dang Ngoc Anh Suong, Jung-Hoon Pyo, Joung-Sun Park, Kouhei Shimaji, Masamitsu Yamaguchi, Mi-Ae Yoo
Publikováno v:
Cellular signalling. 42
Jumonji (Jmj)/Jarid2 is a DNA-binding transcriptional repressor mediated via histone methylation. Nevertheless, the well-known function of Jmj is as a scaffold for the recruitment of various complexes including Polycomb repressive complex 2 (PRC2), a
Autor:
Hyun Jin Na, Young-Shin Kim, Jung Hoon Pyo, Ho-Jun Jeon, Joung Sun Park, Robert Arking, Mi-Ae Yoo
Publikováno v:
Biochemical and Biophysical Research Communications. 450(2):961-965
Age-related changes in long-lived tissue-resident stem cells may be tightly linked to aging and age-related diseases such as cancer. Centrosomes play key roles in cell proliferation, differentiation and migration. Supernumerary centrosomes are known