Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jouko Uusitalo"'
Autor:
Mika Scheinin, Risto Lammintausta, Camilla Stjernschantz, Jouni Vuorinen, Pasi Tapanainen, Olavi Pelkonen, Terhi Lehtinen, Marita Kailajärvi, Jouko Uusitalo, Miia Turpeinen
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP en
Externí odkaz:
https://doaj.org/article/a788bfc9b5ac408ba34f2b49ea039e71
Publikováno v:
Journal of Essential Oil Research. Mar/Apr2006, Vol. 18 Issue 2, p134-138. 5p.
Autor:
Miia Turpeinen, Mika Scheinin, Terhi Lehtinen, Pasi Tapanainen, Camilla Stjernschantz, Jouni Vuorinen, Marita Kailajärvi, Risto Lammintausta, Olavi Pelkonen, Jouko Uusitalo
Publikováno v:
International Journal of Molecular Sciences
Volume 14
Issue 7
Pages 14064-14075
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
Volume 14
Issue 7
Pages 14064-14075
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14064-14075 (2013)
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61adb9239508801f6d030457f1a53aa6
https://doi.org/10.3390/ijms140714064
https://doi.org/10.3390/ijms140714064
Autor:
Miia Turpeinen, Jouko Uusitalo, Olavi Pelkonen, Ari Tolonen, Pasi Koskimies, Risto Lammintausta
Publikováno v:
Drug Metabolism and Personalized Therapy. 31
Background Metabolite profiles of ospemifene, a novel nonsteroidal selective estrogen receptor modulator, were surveyed as part of its development. Methods The pharmacokinetics of ospemifene and its two major, pharmacologically active metabolites 4-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6eb769c98d7e7cdd7e03934a143159
https://doi.org/10.1515/dmpt-2015-0020
https://doi.org/10.1515/dmpt-2015-0020
Autor:
Jouko Uusitalo, Christophe Chesne, Miia Turpeinen, Olavi Pelkonen, André Guillouzo, Ari Tolonen
Publikováno v:
Toxicology in Vitro. 23:748-753
Practically all human hepatocyte cell lines are deficient in major cytochrome P450 (CYP)-related enzyme activities, making them unrepresentative of in vivo hepatocytes. We have used the recently developed HepaRG cell line to determine the spectrum of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2376768d942261989eadd221b2c4d2
https://doi.org/10.1016/j.tiv.2009.03.008
https://doi.org/10.1016/j.tiv.2009.03.008
Publikováno v:
Drug Metabolism and Disposition. 35:1135-1141
Timolol has mainly been used topically for the treatment of glaucoma. It has been suggested that the drug is metabolized by cytochrome P450 CYP2D6. The matter has not, however, been extensively studied. The aim here was to tentatively identify timolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d6641dd735ae660ad422a252a1a53e
https://doi.org/10.1124/dmd.106.012906
https://doi.org/10.1124/dmd.106.012906
Autor:
Jussi Koivunen, Siri Lehtonen, Miia Turpeinen, Anu Olkku, Anitta Mahonen, Hannu-Ville Leskelä, Petri Lehenkari, Katri S. Selander, Lauri Kangas, Jouko Uusitalo, Olavi Pelkonen
Publikováno v:
Bone. 39:1026-1034
Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43b050a401fe9f535cec3c15abfaa70
https://doi.org/10.1016/j.bone.2006.05.003
https://doi.org/10.1016/j.bone.2006.05.003
Autor:
Jouko Uusitalo, Jukka Mönkkönen, Olavi Pelkonen, Paavo Honkakoski, Miia Turpeinen, Timo Korjamo
Publikováno v:
Pharmaceutical Research. 23:1991-2001
To characterise in detail the patterns of expression and functional activities of CYP and efflux pump genes in Caco-2 cells stably transfected with human Pregnane X Receptor or murine Constitutive Androstane Receptor. Cell lines transfected with nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6d77c10353a6ef430439894f7e79ea
https://doi.org/10.1007/s11095-006-9068-4
https://doi.org/10.1007/s11095-006-9068-4
Publikováno v:
Journal of Essential Oil Research. 18:134-138
The effect of harvesting time on the quality and quantity of mint oils produced from plants grown in short summer and long-day climatic conditions of northern Finland (64°40′N and 25°E) was examined to determine what growth stage is best for cutt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b88e198fd88717dcb29bd9430bb3f3
https://doi.org/10.1080/10412905.2006.9699043
https://doi.org/10.1080/10412905.2006.9699043
Publikováno v:
European Journal of Pharmaceutical Sciences. 25:155-162
A simple but efficient method for determination of labile protons in drug metabolites using post-column infusion of deuterium oxide (D2O) in liquid chromatography/mass spectrometry (LC/MS) experiments with electrospray ionization and time-of-flight m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4335712a8f37e5e5866715c40273e93d
https://doi.org/10.1016/j.ejps.2005.02.005
https://doi.org/10.1016/j.ejps.2005.02.005