Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jouhara Chouitar"'
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 614K, Cellular effects of TAK-632, vemurafenib, and TAK-733 on MAPK signaling (S1); Model describing RAF paradoxical activation (S2); Effects of TAK-632 and vemurafenib on BRAF kinase activity (S3); Reversibility of TAK-632 and vemurafenib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcaf05c51ce47ecf2912f5b05346bc5
https://doi.org/10.1158/0008-5472.22398855.v1
https://doi.org/10.1158/0008-5472.22398855.v1
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 103K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6e57be0280b50c7eb627a772539273
https://doi.org/10.1158/0008-5472.22398852
https://doi.org/10.1158/0008-5472.22398852
Autor:
Sei Yoshida, Tomoyasu Ishikawa, Masanori Okaniwa, Katherine Galvin, Elizabeth Carideo, Jouhara Chouitar, Jill Donelan, Shuntarou Tsuchiya, Takeo Arita, Akito Nakamura
PDF file - 119K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed2773d2e203edffde7e16a28cb8d4c
https://doi.org/10.1158/0008-5472.22398858.v1
https://doi.org/10.1158/0008-5472.22398858.v1
Autor:
Natalie Roy D’Amore, Shih-Chung Huang, Sharmila Adhikari, Dylan England, David Lok, Anna Lublinsky, Jouhara Chouitar, Klaudia Foley, Patrick J. LeRoy, Emily F. Calderwood, Ji Zhang, Alexandra E. Gould, James E. Brownell, Sean J. Harrison, Li-Ting Ma, Yu Yang, Saurabh Menon
Publikováno v:
Bioorganicmedicinal chemistry. 28(19)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describe
Autor:
Mi-Sook Kim, Mansoureh Rezaei, Jouhara Chouitar, Katherine Brewer, Michael D. Smith, Alexandra E. Gould, Katherine Galvin, Shih-Chung Huang, Dong Mei Zhang, Sharmila Adhikari, Hirotake Mizutani, Steven P. Langston, Dylan England, Paul D. Greenspan, Emily F. Calderwood, Craig Fisher, Sean J. Harrison, Li-Ting Ma, Saurabh Menon, Roushan Afroze, Jeffery Gaulin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1156-1160
Investigations of a biaryl ether scaffold identified tetrahydronaphthalene Raf inhibitors with good in vivo activity; however these compounds had affinity toward the hERG potassium channel. Herein we describe our work to eliminate this hERG activity
Autor:
Katherine Galvin, Shuntarou Tsuchiya, Jouhara Chouitar, Sei Yoshida, Tomoyasu Ishikawa, Jill Donelan, Elizabeth Carideo, Masanori Okaniwa, Takeo Arita, Akito Nakamura
Publikováno v:
Cancer Research. 73:7043-7055
The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of melanoma cells. Somatic mutations in BRAF and NRAS are frequently observed in melanoma. Recently, the BRAF inhibitors vemurafenib and
Autor:
Ping Li, Douglas Bowman, Helen He, Zhongmin Xiang, Zhi Li, Lunyin Yu, Natalie Roy D’Amore, James E. Brownell, Jie Yu, Jouhara Chouitar, Stephen Tirrell, Matthew Theisen, Yu Yang
Publikováno v:
Journal of Biomarkers
Objective. Use of tyramide signal amplification (TSA) to detect autophagy biomarkers in formalin fixed and paraffin embedded (FFPE) xenograft tissue. Materials and Methods. Autophagy marker regulation was studied in xenograft tissues using Amp HQ IHC
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Autor:
Natalie Roy D’Amore, Jie Yu, James E. Brownell, Evan Luongo, Zhongmin Xiang, Lunyin Yu, Jouhara Chouitar, Kerri Lasky, Helen He, Yu Yang, Chris Simpson, Kristin E. Burke, Doug Bowman, Stephen Tirrell
Publikováno v:
Cancer Research. 75:2908-2908
Immunohistochemistry (IHC) is a powerful tool for studying pharmacodynamic biomarkers in tissue samples. However, IHC using standard methodologies to monitor autophagy has met with limited success due to the technical difficulties involved in detecti
Autor:
Akito Nakamura, Masanori Okaniwa, Tomoyasu Ishikawa, Elizabeth Carideo, Shuntarou Tsuchiya, Jill Donelan, Katherine Galvin, Jouhara Chouitar, Sei Yoshida, Takeo Arita
Publikováno v:
Cancer Research. 74:4247-4247
Melanoma is one of the deadliest and most aggressive forms of skin cancer, arising from the malignant transformation of pigment-producing cells, melanocytes. The mitogen-activated protein kinase (MAPK) pathway is particularly important for the surviv