Outcomes of patients with COVID-19 acute respiratory distress syndrome requiring invasive mechanical ventilation admitted to an intensive care unit in South Africa

Autor: Arnold-Day, C, van Zyl-Smit, R N, Joubert, IA, Thomson, D A, Fredericks, D L, Miller, M G A, Michell, W L, Semple, P L, Piercy, J L

Publikováno v: South African Medical Journal; Vol. 112 No. 1 (2022); 34-39
SAMJ: South African Medical Journal, Volume: 112, Issue: 1, Pages: 34-39, Published: JAN 2022

BACKGROUND. Up to 32% of patients with COVID-19 pneumonia may require intensive care unit (ICU) admission or mechanical ventilation. Data from low- and middle-income countries on COVID-19 acute respiratory distress syndrome (ARDS) are limited. Groote

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The optimal management of the patient with COVID-19 pneumonia: HFNC, NIV/CPAP or mechanical ventilation?

Autor: Broadhurst AGB; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Botha C; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Calligaro G; Division of Pulmonology, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa., Lee C; Discipline of Internal Medicine, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Grey's Hospital, Pietermaritzburg, South Africa., Lalla U; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Koegelenberg CFN; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa., Gopalan PD; Discipline of Anaesthesiology and Critical Care, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Joubert IA; Department of Anaesthesia and Peri-operative Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa., Richards GA; Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Allwood BW; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.

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The organisational response of a hospital critical care service to the COVID-19 pandemic: The Groote Schuur Hospital experience.

Autor: Michell WL; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of General Surgery, Department of Surgery, Faculty of Health Sciences, University of Cape Town, South Africa., Joubert IA; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa., Peters S; School of Public Health & Family Medicine, Faculty of Health Sciences, University of Cape Town, South Africa., Fredericks DL; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa., Miller MGA; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa., Piercy JL; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa., Arnold-Day C; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Critical Care, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, South Africa., Thomson DA; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of General Surgery, Department of Surgery, Faculty of Health Sciences, University of Cape Town, South Africa., van Zyl-Smit RN; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Pulmonology, Department of Medicine and UCT Lung Institute, Faculty of Health Sciences, University of Cape Town, South Africa., Calligaro G; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Pulmonology, Department of Medicine and UCT Lung Institute, Faculty of Health Sciences, University of Cape Town, South Africa., Strathie G; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa., Semple PL; Division of Neurosurgery, Department of Surgery, Faculty of Health Sciences, University of Cape Town, South Africa., Hofmeyr R; Department of Anaesthesia and Perioperative Medicine, Faculty of Health Sciences, University of Cape Town, South Africa., Peters D; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa., Dheda K; Division of Critical Care, Groote Schuur Hospital, Cape Town, South Africa.; Division of Pulmonology, Department of Medicine and UCT Lung Institute, Faculty of Health Sciences, University of Cape Town, South Africa.

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In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization.

Autor: Winter P; Department of Biosciences, University of Salzburg, Salzburg, Austria., Stubenvoll S; Department of Biosciences, University of Salzburg, Salzburg, Austria., Scheiblhofer S; Department of Biosciences, University of Salzburg, Salzburg, Austria., Joubert IA; Department of Biosciences, University of Salzburg, Salzburg, Austria., Strasser L; Department of Biosciences, University of Salzburg, Salzburg, Austria., Briganser C; Department of Biosciences, University of Salzburg, Salzburg, Austria., Soh WT; Department of Biosciences, University of Salzburg, Salzburg, Austria., Hofer F; Center of Molecular Biosciences & Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Kamenik AS; Center of Molecular Biosciences & Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Dietrich V; Center of Molecular Biosciences & Institute of Organic Chemistry, University of Innsbruck, Innsbruck, Austria., Michelini S; Department of Biosciences, University of Salzburg, Salzburg, Austria., Laimer J; Department of Biosciences, University of Salzburg, Salzburg, Austria., Lackner P; Department of Biosciences, University of Salzburg, Salzburg, Austria., Horejs-Hoeck J; Department of Biosciences, University of Salzburg, Salzburg, Austria., Tollinger M; Center of Molecular Biosciences & Institute of Organic Chemistry, University of Innsbruck, Innsbruck, Austria., Liedl KR; Center of Molecular Biosciences & Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria., Brandstetter J; Department of Biosciences, University of Salzburg, Salzburg, Austria., Huber CG; Department of Biosciences, University of Salzburg, Salzburg, Austria., Weiss R; Department of Biosciences, University of Salzburg, Salzburg, Austria.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Aug 18; Vol. 11, pp. 1824. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).