Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jothi Anantharajan"'
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Alphascreen monitoring of the Six1/Eya2 interaction demonstrates that compound 9987 has no effect on this interaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295b0e35587df3b1089c280380400082
https://doi.org/10.1158/1535-7163.22506058
https://doi.org/10.1158/1535-7163.22506058
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Compound inhibition of different Eya proteins and Eya mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb179ac59f1826999b81687eb856683a
https://doi.org/10.1158/1535-7163.22506052.v1
https://doi.org/10.1158/1535-7163.22506052.v1
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Eya2 and Six1 expression in different lung cancer cell lines, along with the effects of Eya2 and Eya2 D274N on protein localization and EMT markers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47800cc22baa5293d7bd53e419821b02
https://doi.org/10.1158/1535-7163.22506049.v1
https://doi.org/10.1158/1535-7163.22506049.v1
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Eya2 binding to Six1 is critical for its ability to mediate numerous phenotypes in Calu-6 lung cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc5555fa01d8ea3ac6c4052fea03e3
https://doi.org/10.1158/1535-7163.22506046
https://doi.org/10.1158/1535-7163.22506046
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Validation of newly generated Six1 antibody (Ford 1229).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd47e375fb93a5e80b6389d96392c42
https://doi.org/10.1158/1535-7163.22506040
https://doi.org/10.1158/1535-7163.22506040
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Cellular activity of 9987 in HCC4006 cells. HCC4006 cells were treated with 9987 at 5 or 10 mM and the efficacy of 9987 was tested on overall growth, colony formation, motility, and invasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1413f38df62615310297e7dab316bd9f
https://doi.org/10.1158/1535-7163.22506043
https://doi.org/10.1158/1535-7163.22506043
Autor:
CongBao Kang, Heide L. Ford, Rui Zhao, Thomas H. Keller, Jeffrey Hill, Debashis Ghosh, Pratyaydipta Rudra, Juan Marugan, Samarjit Patnaik, Joma Joy, Alvin W. Hung, Grace Lin, Nithya Baburajendran, Yee Khoon Yeo, Elizabeth Yihui Ng, John Wee Liang Kuan, Anna E. Jansson, Melanie A. Blevins, Melanie Y. Vincent, Taylor Hotz, Lingdi Zhang, Hengbo Zhou, Jothi Anantharajan
Crystal structure of Eya2 ED-9987 complex shows three Eya2 ED-9987 complexes in one asymmetric unit, with the 9987-binding pocket in the Eya2-9987 crystal structure overlaps with the binding pocket predicted from mutagenesis studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e737620758af7073e742c2aedc288f
https://doi.org/10.1158/1535-7163.22506055.v1
https://doi.org/10.1158/1535-7163.22506055.v1
Autor:
Jothi Anantharajan, Joma Joy, Alvin W. Hung, CongBao Kang, Weijun Xu, Jeffrey Hill, Elizabeth Yihui Ng, Grace Lin, Rui Zhao, John Wee Liang Kuan, Nithya Baburajendran, Shuang Liu, Heide L. Ford, Yong Yao Loh, Thomas H. Keller, Anna E Jasson, Nur Huda Binte Ahmad, Yee Khoon Yeo
Publikováno v:
Protein Sci
Human eyes absent (EYA) proteins possess Tyr phosphatase activity which is critical for numerous cancer and metastasis promoting activities, making it an attractive target for cancer therapy. In this work, we demonstrate that the inhibitor-bound form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb17293350a31e9142c2a0252d15fa
https://europepmc.org/articles/PMC8819961/
https://europepmc.org/articles/PMC8819961/
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Autor:
Joma Joy, David Quach, Priya Retna, Klement Foo, Boping Liu, John Liang Kuan Wee, Anders Poulsen, Guanghui Tang, Shao Q. Yao, Perlyn Zekui Kwek, Nithya Baburajendran, Wan-Qi Yang, Jothi Anantharajan, Thomas H. Keller, Rong Li, Chong-Jing Zhang, Doris Hui Ying Tee
Targeted covalent inhibitors have re-emerged as validated drugs to overcome acquired resistance in cancer treatment. Herein, by using a carbonyl boronic acid warhead, we report the structure-based design of BCR-ABL inhibitors via reversible covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ce237421bc22447f3c94c78646d05
https://doi.org/10.26434/chemrxiv.13710097
https://doi.org/10.26434/chemrxiv.13710097