Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jotham Wadsworth Coe"'
Autor:
William Farrell, Helen A. Clement, Jack C. Lee, Matthew R. Reese, Neal W. Sach, Kevin Nguyen, Jotham Wadsworth Coe, Louise Bernier, Christopher John Helal, Dennis G. Hall
Publikováno v:
ACS Catalysis. 11:404-413
Chiral cyclobutanes are components of numerous bioactive natural products, and consequently, they have also gained significant attention in medicinal chemistry. Optically enriched cyclobutylboronat...
Autor:
Dennis G. Hall, Jack C. Lee, Louise Bernier, Michele Boghi, Matthew R. Reese, Neal W. Sach, Jotham Wadsworth Coe, Christopher John Helal, William Farrell, Helen A. Clement, Rory M. McDonald
Publikováno v:
Angewandte Chemie International Edition. 58:18405-18409
Cyclobutane rings are important in medicinal chemistry, yet few enantioselective methods exist to access this scaffold. In particular, cyclobutylboronates are receiving increasing attention in the literature due to the synthetic versatility of alkylb
Autor:
Alexander Gontcharov, Peter Jones, Steven W. Kortum, David Pattavina, Seungwon Chung, Peter Robert Rose, Jotham Wadsworth Coe, Tim L. Houck, Javier Magano, Lacey Samp, Anil Rane
Publikováno v:
Organic Process Research & Development. 23:1990-2000
A scalable synthesis of a pan-JAK inhibitor is described. The original synthesis by the Medicinal Chemistry group has been modified to develop a new protecting group strategy, a 3-step telescoped s...
Autor:
Jeanne Chang, Ravi G. Kurumbail, Margaret Fleming, Joanne Brodfuehrer, Katherine L. Lee, Frank Lovering, Shashi Mohan, Heather V. Dowty, Fabien Vincent, Jayasankar Jasti, Steve Kortum, Christoph W. Zapf, Jotham Wadsworth Coe, Christophe Allais, Strohbach Joseph Walter, Nikolaos Papaioannou, Ann Aulabaugh, Julia A. Guzova, Paul Morgan, Richard K. Frisbie, WeiDong Ding, David Hepworth
Publikováno v:
European Journal of Medicinal Chemistry. 145:606-621
Many diseases are believed to be driven by pathological levels of reactive oxygen species (ROS) and oxidative stress has long been recognized as a driver for inflammatory disorders. Apoptosis signal-regulating kinase 1 (ASK1) has been reported to be
Autor:
James H. W. LaFortune, Douglas W. Stephan, Jolie Lam, Jotham Wadsworth Coe, Susanna Sampaolesi
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 48(1)
Herein, 3,5-bicyclic aryl piperidines are derivatized to generate chiral B/N FLPs. Initially, the twofold symmetric amine C6H2F2(C5H8NiPr) 1 was converted in a series of synthetic steps to the styrene-derivative C6HF2(C5H8NiPr)(CH[double bond, length
Autor:
Jotham Wadsworth Coe, Brajesh K. Rai, Sidney Liang, Keith Dlugolenski, Jennifer E. Davoren, Erik Alphie Lachapelle, Rebecca E. O’Connor, Deane M. Nason, Christine C. Orozco, David Gray, Rouba Kozak, Christopher John Helal, Brian Samas, Yue Liu, Michelle A. Salafia, Anthony R. Harris, Wenjian Xu
Publikováno v:
Journal of medicinal chemistry. 61(24)
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known D1-selective agonists are catecholamines that bring about receptor desensitization and undergo rapid m
Autor:
Suman Luthra, Graham M. West, Jeremy T. Starr, Matthew Frank Brown, Matthew F. Calabrese, Jinshan Chen, Hongyao Zhu, Xiayang Qiu, Daniel P. Uccello, Matthew Merrill Hayward, Jeanne S. Chang, Jotham Wadsworth Coe, Kathleen A. Farley, Kris A. Borzilleri, Mark C. Noe, Justin I. Montgomery, Adam M. Gilbert, Veerabahu Shanmugasundaram, Lara C. Czabaniuk, Robert M. Oliver, Carmen N. Garcia-Irrizary, Brandon P. Schuff, Chuong Nguyen, Yingrong Xu, James Schiemer, Jaymin C. Shah, Xidong Feng, Mark Niosi, Jennifer A. Young, WeiDong Ding, Ayman El-Kattan, Adelajda Zorba, James F. Smith
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and subsequent degradation of the target. They present an exciting opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf434de63be490efb6416cf59a222839
https://europepmc.org/articles/PMC6077745/
https://europepmc.org/articles/PMC6077745/
Autor:
Jotham Wadsworth Coe, Alpay Dermenci, Philippe Nuhant, Christophe Allais, Andrew C. Flick, Olugbeminiyi O. Fadeyi, Ming Z. Chen, James J. Mousseau
Publikováno v:
Organic Letters. 17:4292-4295
A versatile synthesis of 7-azaindoles from substituted 2-fluoropyridines is described. C3-metalation and 1,4-addition to nitroolefins provide substituted 2-fluoro-3-(2-nitroethyl)pyridines. A facile oxidative Nef reaction/reductive amination/intramol
Autor:
Louis Leung, Jonathan Langille, John I. Trujillo, Paul B. Balbo, Jason Jussif, Jill Chrencik, Martin Hegen, Felix Vajdos, Atli Thorarensen, Sarah Soucy, Adam M. Gilbert, Jean-Baptiste Telliez, Tsung Lin, Ray Unwalla, Matthew Merrill Hayward, Justin I. Montgomery, Sidney Liang, Fabien Vincent, Robert M. Czerwinski, Ye Che, Martin E. Dowty, Mary Ellen Banker, Xin Yang, Matthew Frank Brown, Agustin Casimiro-Garcia, Jotham Wadsworth Coe, Brian Juba
Publikováno v:
Journal of medicinal chemistry. 60(5)
Significant work has been dedicated to the discovery of JAK kinase inhibitors resulting in several compounds entering clinical development and two FDA approved NMEs. However, despite significant effort during the past 2 decades, identification of hig
Autor:
Jotham Wadsworth Coe, Phillip J. Fiore, Ian Edmonds, Jeffrey B. Sperry, Wiglesworth Kristin, Eugene Lvovich Piatnitski Chekler, Jonathan Langille, David C. Boyles, Roberta Louise Dorow, David B. Damon
Publikováno v:
Organic Process Research & Development. 18:1752-1758
This work describes the optimization and scale-up of a Buchwald–Hartwig amination reaction for the preparation of a pharmaceutical intermediate. This C–N bond formation is challenged by the use of a chiral primary amine, which both adds cost and