Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Josy M. Gubbens-Stibbe"'
Autor:
Josy M. Gubbens-Stibbe, Nicoline Treijtel, Lambertus A. Peletier, Piet H. van der Graaf, Meindert Danhof, Klaas P. Zuideveld, Hugo J. Maas
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:330-338
The objective of this investigation was to characterize quantitatively the pharmacodynamic interaction between N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide (WAY-100,635) and R-(+)-8-hydroxy-2-(di-n-propylamino)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7bdbf385183504ee6b8f7b86818ffb
https://doi.org/10.1124/jpet.300.1.330
https://doi.org/10.1124/jpet.300.1.330
Autor:
M. Danhof, J von Frijtag, Josy M. Gubbens-Stibbe, E Tukker, D Künzel, Eugene H. Cox, P H van der Graaf, M Garrido, Adriaan P. IJzerman
Publikováno v:
Pharmaceutical Research. 17:653-659
Purpose. The objective of this investigation was to determine theinfluence of pre-treatment with the irreversible μ-opioid receptorantagonist β-funaltrexamine (β-FNA) on thepharmacokinetic-pharmacodynamic (PK/PD) relationship of alfentanil in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c80d351949ae3b4e86b29f388c8832e
https://doi.org/10.1023/a:1007513812018
https://doi.org/10.1023/a:1007513812018
Publikováno v:
Anesthesiology. 90:535-544
Background The purpose of this study was to investigate the in vivo pharmacodynamics and the pharmacodynamic interactions of remifentanil and its major metabolite, GR90291, in a rat electroencephalographic model. Methods Remifentanil and GR90291 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f312034b7d5409c5c5b63e63f4a81527
https://doi.org/10.1097/00000542-199902000-00030
https://doi.org/10.1097/00000542-199902000-00030
Publikováno v:
Pharmaceutical Research. 14:1804-1810
Purpose. Transdermal transport rates of the dopamine agonist R-apomorphine were determined in patients with idiopathic Parkinson's disease (IPD). Apomorphine was applied by iontophoresis at two current densities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd160c2c7a408eded34515b719a3f5d4
https://doi.org/10.1023/a:1012152401715
https://doi.org/10.1023/a:1012152401715
Publikováno v:
Psychopharmacology. 103:384-387
The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7a0fdd7bd58cbc8afdb61fe60585ea
https://doi.org/10.1007/bf02244294
https://doi.org/10.1007/bf02244294
Autor:
F. L. C. Wolters, Lambertus A. Peletier, P H van der Graaf, E Tukker, Josy M. Gubbens-Stibbe, M. Danhof, S. A. G. Visser
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 304(1)
A mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) model for neuroactive steroids, comprising a separate characterization of 1) the receptor activation process and 2) the stimulus-response relationship, was applied to various nonsteroidal GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bf6cd46b258341ff62ac4196e7d591
https://pubmed.ncbi.nlm.nih.gov/12490579
https://pubmed.ncbi.nlm.nih.gov/12490579
Autor:
R.J. van der Geest, Harry E. Boddé, Meindert Danhof, P. P. Kruger, Josy M. Gubbens-Stibbe, T. van Laar
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 702(1-2)
Analytical methods are described for the selective, rapid and sensitive determination of R- and S-apomorphine, apocodeine and isoapocodeine and the glucuronic acid and sulfate conjugates in plasma and urine. The methods involve liquid-liquid extracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453565c2a9700d5fec46985b2d871a7
https://pubmed.ncbi.nlm.nih.gov/9449564
https://pubmed.ncbi.nlm.nih.gov/9449564