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pro vyhledávání: '"Josue Obed Jaramillo"'
Autor:
Luke A. Pattison, Cintya Lopez-Lopez, Stephen Vanner, Daniel P. Poole, Dane D. Jensen, Brian L. Schmidt, Nestor N. Jiménez-Vargas, Nigel W. Bunnett, Tina Marie Lieu, Josue Obed Jaramillo, Peishen Zhao, Rocco Latorre
Publikováno v:
J Biol Chem
Proteases sustain hyperexcitability and pain by cleaving protease-activated receptor-2 (PAR(2)) on nociceptors through distinct mechanisms. Whereas trypsin induces PAR(2) coupling to Gα(q), Gα(s), and β-arrestins, cathepsin-S (CS) and neutrophil e