Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Josue Jaramillo-Polanco"'
Autor:
Yang Yu, Quentin K. Tsang, Josue Jaramillo-Polanco, Alan E. Lomax, Stephen J. Vanner, David E. Reed
Publikováno v:
J Neurosci
While effective in treating abdominal pain, opioids have significant side effects. Recent legalization of cannabis will likely promote use of cannabinoids as an adjunct or alternative to opioids, despite a lack of evidence. We aimed to investigate wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5b9d5e33f83487947cf57ed022f2ce
https://doi.org/10.1523/jneurosci.0641-22.2022
https://doi.org/10.1523/jneurosci.0641-22.2022
Autor:
Giada De Palma, Chiko Shimbori, David E. Reed, Yang Yu, Virginia Rabbia, Jun Lu, Nestor Jimenez-Vargas, Jessica Sessenwein, Cintya Lopez-Lopez, Marc Pigrau, Josue Jaramillo-Polanco, Yong Zhang, Lauren Baerg, Ahmad Manzar, Julien Pujo, Xiaopeng Bai, Maria Ines Pinto-Sanchez, Alberto Caminero, Karen Madsen, Michael G. Surette, Michael Beyak, Alan E. Lomax, Elena F. Verdu, Stephen M. Collins, Stephen J. Vanner, Premysl Bercik
Publikováno v:
Science translational medicine. 14(655)
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed that decreasing intake of fermentable carbohydrates improved abdominal pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38694ecd5d2f04eb54b775b1b3398233
https://pubmed.ncbi.nlm.nih.gov/35982254
https://pubmed.ncbi.nlm.nih.gov/35982254
Autor:
Claudius E. Degro, Quentin Tsang, Brian L. Schmidt, Matthew J. Wisdom, Diana Daeun Bok, Cintya D. Lopez Lopez, Alan E. Lomax, Nigel W. Bunnett, Rocco Latorre, Zachary E Snow, Mabel Guzman-Rodriguez, Yang Yu, David E. Reed, Nestor N. Jiménez-Vargas, Josue Jaramillo-Polanco, Christoph Stein, Dane D. Jensen, Stephen Vanner, Kara Gross Margolis
Publikováno v:
Gut. 71(4)
ObjectiveThe effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c1af585ceecdbda1a35e47e892e272
https://pubmed.ncbi.nlm.nih.gov/33875448
https://pubmed.ncbi.nlm.nih.gov/33875448
Autor:
Shavonne Teng, Stephen Vanner, Alan Hegron, Jesse J. DiCello, Yang Yu, Josue Jaramillo-Polanco, Michelle L. Halls, Daniel P. Poole, Dane D. Jensen, Nicholas A. Veldhuis, Kam W. Leong, Nestor N. Jiménez-Vargas, Meritxell Canals, Brian L. Schmidt, Cintya Lopez-Lopez, Jing Gong, Alan E. Lomax, Simona E. Carbone, Matthew J. Wisdom, David E. Reed, Pradeep Rajasekhar, Nigel W. Bunnett, Rocco Latorre
Publikováno v:
Proc Natl Acad Sci U S A
Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a17ff512ec645e122b6824c448c7ae
https://pubmed.ncbi.nlm.nih.gov/32546520
https://pubmed.ncbi.nlm.nih.gov/32546520
Autor:
Lisse Decraecker, Raf Bisschops, Stavroula Theofanous, Bart N. Lambrecht, Javier Aguilera-Lizarraga, Morgane Florens, Alexandre Denadai-Souza, Frank A. Redegeld, Josue Jaramillo-Polanco, Jiyeon Si, Kim Van Beek, Mira M. Wouters, Yeranddy A. Alpizar, Gianluca Matteoli, Naomi Fabre, Dafne Balemans, Rik Schrijvers, Guy E. Boeckxstaens, Stephanie Mondelaers, Sven Hendrix, David E. Reed, Maria Cuende-Estevez, Hans-Reimer Rodewald, Cedric Bosteels, Sales Ibiza Martínez, Maxim Nelis, Goele Bosmans, Piyush Jain, Eluisa Perna, Nathalie Stakenborg, Deirdre Cabooter, Ramona A. Hoh, Maria Francesca Viola, Jessica Strid, Patrick Augustijns, Ricard Farré, Scott D. Boyd, Iris Appeltans, Cintya Lopez-Lopez, Christine Breynaert, Karel Talavera, Stephen Vanner, Thorsten B. Feyerabend, Jeroen Raes
Publikováno v:
Nature, 590(7844), 151. Nature Research
Nature, 590(7844), 151-156. Nature Publishing Group
NATURE
Nature
Nature, 590(7844), 151-156. Nature Publishing Group
NATURE
Nature
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal(1), leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the scientific and lay communities in this issue ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e91a752e8dd8c5c1ea92d7674bf672
https://pubmed.ncbi.nlm.nih.gov/33526865
https://pubmed.ncbi.nlm.nih.gov/33526865
Autor:
Takanobu Okamoto, Raquel Guerrero-Alba, Nigel W. Bunnett, Stephen Vanner, Eduardo E. Valdez-Morales, Nestor N. Jiménez-Vargas, Alan E. Lomax, Cintya Lopez-Lopez, Yasmin Nasser, Josue Jaramillo-Polanco
Publikováno v:
Gut
Aims and backgroundPsychological stress accompanies chronic inflammatory diseases such as IBD, and stress hormones can exacerbate pain signalling. In contrast, the endogenous opioid system has an important analgesic action during chronic inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f2006acefd5d0712166cf1e4560b96
https://doi.org/10.1136/gutjnl-2016-311456
https://doi.org/10.1136/gutjnl-2016-311456
Autor:
Luis M. Montaño, Carlos Barajas-López, Josue Jaramillo-Polanco, Andrómeda Liñán-Rico, Juan Francisco Jiménez-Bremont, Rosa Espinosa-Luna, Marcela Miranda-Morales
Publikováno v:
Biochemical and Biophysical Research Communications. 477:54-61
To investigate if channels with different stoichiometry are formed from P2X2 receptor isoforms during their heterologous co-expression. The two-electrode voltage-clamp technique was used to measured ATP induced currents in Xenopus laevis oocytes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f4e4a5521f72557b467e4b8bef3a1a
https://doi.org/10.1016/j.bbrc.2016.06.020
https://doi.org/10.1016/j.bbrc.2016.06.020
Autor:
Y Zhang, Jun Lu, Elena F. Verdu, Michael Beyak, C Shimbori, Stephen M. Collins, Stephanie Vanner, P Bercik, J Sessenwein, Alan E. Lomax, Marc Pigrau, G De Palma, Josue Jaramillo-Polanco, Yang Yu, David E. Reed, Cintya Lopez-Lopez, Nestor N. Jiménez-Vargas
Publikováno v:
Brain, Behavior, and Immunity. 76:e15-e16
Gut immune system, microbiota and diet appear to play important roles in irritable bowel syndrome (IBS). Increased levels of colonic mast cell (MC) located in close proximity to mucosal nerves were reported in IBS patients, correlating with increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8681fa6c8797f1463d6bb35192e2a7
https://doi.org/10.1016/j.bbi.2018.11.220
https://doi.org/10.1016/j.bbi.2018.11.220
Autor:
Raúl Loera-Valencia, María Guadalupe Nieto Pescador, Josue Jaramillo-Polanco, Juan Francisco Jiménez Bremont, Carlos Barajas-López, Andrómeda Liñán-Rico
Publikováno v:
Pharmacology & Pharmacy. :341-362
Purinergic P2X receptors are a family of ligand-gated cationic channels activated by extracellular ATP. P2X subunit protein sequences are highly conserved between vertebrate species. However, they can generate a great diversity of coding splicing var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb15ca3b3ea436a20977789cba6bae3c
https://doi.org/10.4236/pp.2015.68036
https://doi.org/10.4236/pp.2015.68036
Autor:
Rosa Espinosa-Luna, Josue Jaramillo-Polanco, Carlos Barajas-López, Diana P. Portales-Pérez, Juan D. Cortés-García, Jessica G. Rodríguez-Meléndez, Karen S. Gómez-Coronado, Luis M. Montaño, Cintya López-López
Publikováno v:
European journal of pharmacology. 793
To characterize the presence and general properties of P2X1 receptors in single human monocytes we used RT-PCR, flow cytometry, and the patch-clamp and the two-electrode voltage-clamp techniques. Most human monocytes expressed the canonical P2X1 (90%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2d67e383e54ff70003db3f61d8e3db
https://pubmed.ncbi.nlm.nih.gov/27823931
https://pubmed.ncbi.nlm.nih.gov/27823931