Seeking Windows of Opportunity to Shape Lifelong Immune Health: A Network-Based Strategy to Predict and Prioritize Markers of Early Life Immune Modulation

Autor: Jolanda H. M. van Bilsen, Remon Dulos, Mariël F. van Stee, Marie Y. Meima, Tanja Rouhani Rankouhi, Lotte Neergaard Jacobsen, Anne Staudt Kvistgaard, Jossie A. Garthoff, Léon M. J. Knippels, Karen Knipping, Geert F. Houben, Lars Verschuren, Marjolein Meijerink, Shaji Krishnan

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

A healthy immune status is strongly conditioned during early life stages. Insights into the molecular drivers of early life immune development and function are prerequisite to identify strategies to enhance immune health. Even though several starting

Externí odkaz: https://doaj.org/article/914d386a518047b78b96c2747816ec58

Locust bean gum safety in neonates and young infants: An integrated review of the toxicological database and clinical evidence

Autor: Anne Schaafsma, Johannes B. van Goudoever, Jossie A. Garthoff, Lisette Krul, Jaap Schrijver, Yvan Vandenplas, Leo Meunier, Gerrit J.A. Speijers

Publikováno v: Regulatory Toxicology and Pharmacology, 1, 70, 155-169
Meunier, L, Garthoff, J A, Schaafsma, A, Krul, L, Schrijver, J, van Goudoever, J B, Speijers, G & Vandenplas, Y 2014, ' Locust bean gum safety in neonates and young infants: An integrated review of the toxicological database and clinical evidence ', Regulatory Toxicology and Pharmacology, vol. 70, no. 1, pp. 155-169 . https://doi.org/10.1016/j.yrtph.2014.06.023
Regulatory Toxicology and Pharmacology, 70(1), 155-169. Academic Press Inc.

Locust bean gum (LBG) is a galactomannan polysaccharide used as thickener in infant formulas with the therapeutic aim to treat uncomplicated gastroesophageal reflux (GER). Since its use in young infants below 12. weeks of age is not explicitly covere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c2dbcf480278bc437f1f59ec5d9275
https://doi.org/10.1016/j.yrtph.2014.06.023

An integrated approach to the safety assessment of food additives in early life

Autor: Jossie A. Garthoff, Anne Constable, Peter Pressman, Brinda Mahadevan, Dieter Schrenk, Leo Meunier, Gerrit J.A. Speijers, Aaron J O'Sullivan, A. Wallace Hayes

Publikováno v: Toxicology Research and Application, Vol 1 (2017)

During the development of international standards by the Codex Alimentarius Commission, infant foods and their constituent ingredients are subject to rigorous risk analysis and are strictly regulated by many authorities. Various jurisdictions have ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad367cf873db21209dcaab93350961ca
https://doi.org/10.1177/2397847317707370

P3‐374: A medical food Souvenaid ® for Alzheimer patients can be used safely in combination with an acetylcholinesterase inhibitor in an aged rat model

Autor: Jossie A. Garthoff, Patrick Joseph Gerardus Hendrikus Kamphuis, Nick van Wijk, Martijn C. de Wilde, Almar A.M. Kuipers, Laus M. Broersen, Gerrit J.A. Speijers

Publikováno v: Alzheimer's & Dementia. 6

in the NHP were performed following iv bolus and infusion treatment with SAM-760 designed to maintain steady state drug exposure throughout the experiment. Human PET RO was evaluated at approximately tmax and 24 or 48h following oral treatment with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7031e689397a0ec95c5fde0753b9715a
https://doi.org/10.1016/j.jalz.2010.05.1916

A medical food Souvenaid® for AD patients can be used safely in combination with an acetylcholinesterase inhibitor in an aged rat model

Autor: Ladislaus Maria Broersen, Jossie A. Garthoff, Gerrit J.A. Speijers, N. van Wijk, P.J. Kamphuis, M.C. de Wilde

Publikováno v: European Journal of Pharmacology. 668:e36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c539ced44c1bb13ae7279d7e3e80c203
https://doi.org/10.1016/j.ejphar.2011.09.277