A helminth-derived suppressor of ST2 blocks allergic responses

Autor: Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley

Publikováno v: eLife, Vol 9 (2020)

The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru

Externí odkaz: https://doaj.org/article/33d967843f4146868a42245249420393

A helminth-derived suppressor of ST2 blocks allergic responses

Autor: Zala Sekne, E. Suzanne Cohen, Georgia Perona-Wright, Matthew K. Higgins, Martin A. Wear, William F Gregory, Elizabeth C Hinchy, Adefunke Ogunkanbi, Graham Heieis, Abhishek Jamwal, Francesco Vacca, Henry J. McSorley, Holly Webster, Josquin A Nys, Caroline Chauché

Publikováno v: Vacca, F, Chauché, C, Jamwal, A, Hinchy, E C, Heieis, G, Webster, H, Ogunkanbi, A, Sekne, Z, Gregory, W F, Wear, M, Perona-Wright, G, Higgins, M K, Nys, J A, Cohen, E S & Mcsorley, H J 2020, ' A helminth-derived suppressor of ST2 blocks allergic responses ', eLIFE, vol. 9, e54017 . https://doi.org/10.7554/eLife.54017
eLife, Vol 9 (2020)
eLife

The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d50e157d7547282bee91dad218a400a
https://doi.org/10.7554/elife.54017