Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joslyn Mills"'
Autor:
Anita V. Kumar, Joslyn Mills, Wesley M. Parker, Joshua A. Leitão, Diego I. Rodriguez, Sandrine E. Daigle, Celeste Ng, Rishi Patel, Joseph L. Aguilera, Joseph R. Johnson, Shi Quan Wong, Louis R. Lapierre
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107960- (2023)
Summary: In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear. Here, while det
Externí odkaz:
https://doaj.org/article/c53b1b823c6f428899880fae5897d69d
Autor:
Anita V. Kumar, Joslyn Mills
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related proteins in non-canonical degradation and secretion has revealed alternative fates of autophagic c
Externí odkaz:
https://doaj.org/article/2a824a5db4754d2ea8b704d834853d4a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an
Externí odkaz:
https://doaj.org/article/4ef86ee06dbb4d9c9e52a142594e3923
Autor:
Jerrica L. Breindel, Adam Skibinski, Maja Sedic, Ania Wronski-Campos, Wenhui Zhou, Patricia J. Keller, Joslyn Mills, James Bradner, Tamer Onder, Charlotte Kuperwasser
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 943-955 (2017)
Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction and loss of pluripotency. An exception to this appears in the adult human breast, where rare variant epithelial cells exhibit pl
Externí odkaz:
https://doaj.org/article/15112164c4b44467a40b1d0c89dc317d
Supplementary Figures 1-11, Supplementary Tables 1-2 from Chromatin Structure Predicts Epigenetic Therapy Responsiveness in Sarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd84c568db115e946fa4b10f6f9742f
https://doi.org/10.1158/1535-7163.22497228.v1
https://doi.org/10.1158/1535-7163.22497228.v1
Publikováno v:
Aging Cell. 22
Transcription factor EB (TFEB) is a conserved master transcriptional activator of autophagy and lysosomal genes that modulates organismal lifespan regulation and stress resistance. As neurons can coordinate organism-wide processes, we investigated th
Autor:
Anita V. Kumar, Joslyn Mills, Wesley M. Parker, Joshua A. Leitao, Diego I. Rodriguez, Celeste Ng, Joseph L. Aguilera, Joseph R. Johnson, Shi Quan Wong, Louis R. Lapierre
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an
Autor:
Louis R. Lapierre, Joseph R Johnson, Wesley Parker, Joshua A. Leitão, Joslyn Mills, Rishi Patel, Shi Quan Wong, Celeste Ng, Joseph Aguilera, Anita Kumar
The ability of organisms to live long depends largely on the maintenance of proteome stability via proteostatic mechanisms including translational regulation, protein chaperoning and degradation machineries. In several long-lived Caenorhabditis elega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85b7f9db66227fc8f7195cc8e189d1d
https://doi.org/10.21203/rs.3.rs-452997/v1
https://doi.org/10.21203/rs.3.rs-452997/v1
Publikováno v:
Hum Genet
Our understanding of the process of autophagy and its role in health and diseases has grown remarkably in the last two decades. Early work established autophagy as a general bulk recycling process which involves the sequestration and transport of int