Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model

Autor: Joske Millecam, Thomas van Bergen, Stijn Schauvliege, Gunther Antonissen, Ann Martens, Koen Chiers, Ronette Gehring, Elke Gasthuys, Johan Vande Walle, Siska Croubels, Mathias Devreese

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge on the pharmacokinetic and pharmacodynamic properties

Externí odkaz: https://doaj.org/article/c4d4dbb3402e49b4866454f1a3f8afa8

The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research

Autor: Joske Millecam, Laura De Clerck, Elisabeth Govaert, Mathias Devreese, Elke Gasthuys, Wim Schelstraete, Dieter Deforce, Lies De Bock, Jan Van Bocxlaer, Stanislas Sys, Siska Croubels

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Since the implementation of several legislations to improve pediatric drug research, more pediatric clinical trials are being performed. In order to optimize these pediatric trials, adequate preclinical data are necessary, which are usually obtained

Externí odkaz: https://doaj.org/article/9ad973f3364c4711a25bdbb084907d9a

Postnatal Maturation of the Glomerular Filtration Rate in Conventional Growing Piglets As Potential Juvenile Animal Model for Preclinical Pharmaceutical Research

Autor: Elke Gasthuys, Mathias Devreese, Joske Millecam, Stanislas Sys, Katrien Vanderperren, Joris Delanghe, Johan Vande Walle, Marjolein Heyndrickx, Siska Croubels

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential animal model, since they display a high d

Externí odkaz: https://doaj.org/article/c9f0d0f78d1e4c34b101b1ff8a3b41fb

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies

Autor: Thomas van Bergen, Stijn Schauvliege, Koen Chiers, Joske Millecam, Siska Croubels, Mathias Devreese, Ann Martens, Gunther Antonissen

Publikováno v: Laboratory Animals. 54:261-271

The use of juvenile conventional pigs as a preclinical animal model to perform pharmacokinetic (PK), pharmacodynamic (PD) and safety studies for the paediatric population is increasing. Repetitive oral administration of drugs to juvenile pigs is howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0543d231673d7eed96b3c3ad03144c0a
https://doi.org/10.1177/0023677219857106

Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus

Autor: Johan C. A. de Klerk, Pieter L.J. Degraeuwe, Siska Croubels, Sinno H.P. Simons, Karel Allegaert, Swantje Völler, Kian D. Liem, Joske Millecam, Peter Andriessen, Aline G.J. Engbers, Catherijne A. J. Knibbe, Irwin K M Reiss, Robert B. Flint

Publikováno v: British Journal of Clinical Pharmacology, 86, 10, pp. 2028-2039
British Journal of Clinical Pharmacology, 86(10), 2028-2039. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 86, 2028-2039
British Journal of Clinical Pharmacology, 86(10), 2028-2039. Wiley
British Journal of Clinical Pharmacology, 86(10), 2028-2039. Wiley-Blackwell
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

AIMS: Racemic ibuprofen is widely used for the treatment of preterm neonates with patent ductus arteriosus. Currently used bodyweight-based dosing guidelines are based on total ibuprofen, while only the S-enantiomer of ibuprofen is pharmacologically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743f1d8b1372607ba66011e4dea8034b
https://hdl.handle.net/2066/229867