Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Josina C. Reddy"'
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Vismodegib Efficacy in Advanced Basal Cell Carcinoma Maintained with 8-Week Dose Interruptions: A Model-Based Evaluation
Autor: Luna Musib, Josina C. Reddy, Sravanthi Cheeti, Sandhya Girish, Jin Y. Jin, Pascal Chanu, Rene Bruno, Tong Lu, Ivor Caro, Xin Wang
Publikováno v: Journal of Investigative Dermatology. 141:930-933
Summary Long-term use of vismodegib is associated with treatment-emergent adverse drug reactions in clinical trials of patients with locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC). Treatment interruptions have been recommende
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e7811940df2d9f933c300fa8b44e34
https://doi.org/10.1016/j.jid.2020.07.036
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7
Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
Autor: Christine L. Hann, Kenn L. Zerivitz, Glen J. Weiss, Ilsung Chang, Josina C. Reddy, Walter C. Darbonne, Mitesh J. Borad, Charles M. Rudin, Patricia LoRusso, Julie R. Brahmer, Jennifer A. Low, Raoul Tibes, Richard A. Graham, Daniel D. Von Hoff
Publikováno v: Clinical Cancer Research. 17:2502-2511
Purpose: The hedgehog (Hh) signaling pathway, a key regulator of cell growth and differentiation during development is implicated in pathogenesis of certain cancers. Vismodegib (GDC-0449) is a small-molecule inhibitor of smoothened, a key component o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8f292ef1007e57c33072f506192802
https://doi.org/10.1158/1078-0432.ccr-10-2745
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8
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Autor: Daniel D. Von Hoff, Frederic J. de Sauvage, Josina C. Reddy, Walter C. Darbonne, Howard Mackey, Charles M. Rudin, Jennifer A. Low, Bertram L. Lum, Christine L. Hann, James C. Marsters, Patricia LoRusso, Mitesh J. Borad, Julie R. Brahmer, Robert L. Yauch, Glen J. Weiss, Raoul Tibes
Publikováno v: New England Journal of Medicine. 361:1164-1172
Background Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c8f96a281bbdefa7032c5fcc17597b8
https://doi.org/10.1056/nejmoa0905360
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9
WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts
Autor: Christopher R. Burrow, Jonathan D. Licht, George F. Atweh, Josina C. Reddy, Patricia D. Wilson, Lynn M. Schnapp, Deborah Hyink, Seiyu Hosono, Xiang-Nong Luo
Publikováno v: Oncogene. 18:417-427
The WT1 tumor suppressor gene, implicated in hereditofamilial and sporadic Wilms' tumor, is required for normal renal development and is up-regulated during the mesenchymal-epithelial transition. NIH3T3 fibroblasts overexpressing WT1 were less prolif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7966d63be71550d7667d7f4ec2f1c45
https://doi.org/10.1038/sj.onc.1202311
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10
The Transcriptional Effect of WT1 Is Modulated by Choice of Expression Vector
Autor: Josina C. Reddy, Seiyu Hosono, Jonathan D. Licht
Publikováno v: Journal of Biological Chemistry. 270:29976-29982
The WT1 Wilms' tumor suppressor gene encodes a zinc finger transcription factor which plays a critical role in renal and genitourinary development. The WT1 protein was reported to both activate and repress transcription. We found that the transcripti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf14d36ab13c0d8ec8f17a1372f039
https://doi.org/10.1074/jbc.270.50.29976
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