Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Josien Levenga"'
Autor:
Helen Wong, Josien Levenga, Lauren LaPlante, Bailey Keller, Andrew Cooper-Sansone, Curtis Borski, Ryan Milstead, Marissa Ehringer, Charles Hoeffer
Publikováno v:
eLife, Vol 9 (2020)
AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and
Externí odkaz:
https://doaj.org/article/29951fa61b6c48d4a3d2d5fd4522644d
Autor:
Josien Levenga, Helen Wong, Ryan A Milstead, Bailey N Keller, Lauren E LaPlante, Charles A Hoeffer
Publikováno v:
eLife, Vol 6 (2017)
AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its direct role has not been studied. Moreover, three highly relate
Externí odkaz:
https://doaj.org/article/4bd7dfe2ec9842989df67eae9152e3c1
Autor:
Josien Levenga, Shigemi Hayashi, Femke M.S. de Vrij, Sebastiaan K. Koekkoek, Herma C. van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A.M. Buijsen, Andreea S. Pop, Baltazar GomezMancilla, David L. Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A. Oostra
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 311-317 (2011)
Fragile X syndrome, the most common form of inherited intellectual disability, is caused by a lack of FMRP, which is the product of the Fmr1 gene. FMRP is an RNA-binding protein and a component of RNA-granules found in the dendrites of neurons. At th
Externí odkaz:
https://doaj.org/article/2805dc9459cd4a9eb1549444b3d8d9c4
Autor:
Josien Levenga, Ronald A.M. Buijsen, Maria Rifé, Hervé Moine, David L. Nelson, Ben A. Oostra, Rob Willemsen, Femke M.S. de Vrij
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 241-250 (2009)
Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines. We examined the role of functional domains of FMRP in neuronal RNA-granule formation and dendritic tra
Externí odkaz:
https://doaj.org/article/d58d87658b9d4e1fb6e0706e5be2a970
Autor:
Femke M.S. de Vrij, Josien Levenga, Herma C. van der Linde, Sebastiaan K. Koekkoek, Chris I. De Zeeuw, David L. Nelson, Ben A. Oostra, Rob Willemsen
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 127-132 (2008)
Lack of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most common form of inherited mental retardation. FMRP is an RNA-binding protein and is a component of messenger ribonucleoprotein complexes, associated with brain pol
Externí odkaz:
https://doaj.org/article/77bbfe96b44f48d1bf8cdeb06bd397b1
Autor:
Clarence Mills, Andrew Riching, Ashleigh Keller, Jesse Stombaugh, Amanda Haupt, Elena Maksimova, Sarah M. Dickerson, Emily Anderson, Kevin Hemphill, Chris Ebmeier, John A. Schiel, Josien Levenga, Matthew Perkett, Anja van Brabant Smith, Zaklina Strezoska
Publikováno v:
The CRISPR journal.
While CRISPR interference (CRISPRi) systems have been widely implemented in pooled lentiviral screening, there has been limited use with synthetic guide RNAs for the complex phenotypic readouts enabled by experiments in arrayed format. Here we descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2664a14eaa32eb07fa3aa361af1aa3e0
https://pubmed.ncbi.nlm.nih.gov/36257604
https://pubmed.ncbi.nlm.nih.gov/36257604
Publikováno v:
Cerebral Cortex Communications
Protein kinase B (PKB/AKT) is a central kinase involved in many neurobiological processes. AKT is expressed in the brain as three isoforms, AKT1, AKT2, and AKT3. Previous studies suggest isoform-specific roles in neural function, but very few studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d544be569e1d8bb42fa7266d2306bc42
https://doi.org/10.1093/texcom/tgab036
https://doi.org/10.1093/texcom/tgab036
Autor:
Ryan A Milstead, Andrew Cooper-Sansone, Bailey N. Keller, Helen Wong, Charles A. Hoeffer, Josien Levenga, Lauren E LaPlante, Curtis Borski, Marissa A. Ehringer
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ab9261b6c1c34c2eb5f239f9ee95ca
https://doi.org/10.7554/elife.56630
https://doi.org/10.7554/elife.56630
Autor:
Bailey N. Keller, Curtis Borski, Charles A. Hoeffer, Josien Levenga, Lauren E LaPlante, Marissa A. Ehringer, Ryan A Milstead, Helen Wong, Andrew Cooper-Sansone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89886f513fb64cbd9a69df689cc2ef1
https://doi.org/10.7554/elife.56630.sa2
https://doi.org/10.7554/elife.56630.sa2
Publikováno v:
Neuroscience
Down syndrome (DS) results from the triplication of genes located on human chromosome 21 (Hsa21). Though many cognitive and behavioral impairments are associated with DS, sleep disturbances remain poorly understood despite being a reported phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a40fa14c6dad4b868d0a7bd87944a2d
http://europepmc.org/articles/PMC7255843
http://europepmc.org/articles/PMC7255843