Comparing the cumulative live birth rate of cleavage-stage versus blastocyst-stage embryo transfers between IVF cycles: a study protocol for a multicentre randomised controlled superiority trial (the ToF trial)

Autor: Jannie van Echten-Arends, Brigitte Arends, Max H. J. N. Curfs, E. R. Groenewoud, Moniek van der Zanden, Jacques W.M. Maas, Maaike A. F. Traas, Kathrin Fleischer, Jantien Visser, Liliana Ramos, Angelique J. C. M. van Dongen, Didi D.M. Braat, Harold R. Verhoeve, Carlijn G. Vergouw, Yvonne Wurth, Quirine Pieterse, Lucette A. J. van der Westerlaken, Madelon van Wely, Jan Bruin, Janneke J. Brink-van der Vlugt, Sebastiaan Mastenbroek, Josien G. Derhaag, Els Slappendel, Evert J.P. van Santbrink, Simone Cornelisse

Publikováno v: BMJ Open, 11(1):042395. BMJ PUBLISHING GROUP
BMJ Open, 11(1):e042395. BMJ Publishing Group
BMJ open, 11(1):e042395. BMJ Publishing Group
BMJ Open, 11(1):042395. BMJ Publishing Group
BMJ Open
BMJ Open, 11
Cornelisse, S, Ramos, L, Arends, B, Brink-van der Vlugt, J J, de Bruin, J P, Curfs, M H J N, Derhaag, J, van Dongen, A, van Echten-Arends, J, Groenewoud, E R, Maas, J W M, Pieterse, Q, van Santbrink, E J P, Slappendel, E, Traas, M A F, Visser, J, Vergouw, C G, Verhoeve, H R, van der Westerlaken, L A J, Wurth, Y, van der Zanden, M, Braat, D D M, van Wely, M, Mastenbroek, S & Fleischer, K 2021, ' Comparing the cumulative live birth rate of cleavage-stage versus blastocyst-stage embryo transfers between IVF cycles: A study protocol for a multicentre randomised controlled superiority trial (the ToF trial) ', BMJ Open, vol. 11, no. 1, e042395 . https://doi.org/10.1136/bmjopen-2020-042395
BMJ Open, 11, 1
BMJ Open, Vol 11, Iss 1 (2021)

IntroductionIn vitro fertilisation (IVF) has evolved as an intervention of choice to help couples with infertility to conceive. In the last decade, a strategy change in the day of embryo transfer has been developed. Many IVF centres choose nowadays t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9020ca3c6548b4149427f707447e68ba
https://research.rug.nl/en/publications/778c50a2-1f5f-40da-b097-7fe479b32179

Multi-centre evaluation of a comprehensive preimplantation genetic test through haplotyping-by-sequencing

Autor: Jessie Theuns, Katrien Omer François, Han G. Brunner, Masoud Zamani Esteki, Edith Coonen, Thierry Voet, Joris Vermeesch, Dennis Lorson, Cindy Melotte, Rebecca Richards, Olga Tšuiko, Sophie Debrock, Marion Drüsedau, Aspasia Destouni, Karen Peeraer, Scott Happe, Jos Dreesen, Aimee D C Paulussen, Kasper W.J. Derks, Benoit Devogelaere, Jeroen Meekels, Eftychia Dimitriadou, Josien G. Derhaag, Chris M. J. van Uum, Joke Allemeersch, Heleen Masset, Christine E. M. de Die-Smulders

Publikováno v: Human Reproduction, 34(8), 1608-1619. Oxford University Press

STUDY QUESTION Can reduced representation genome sequencing offer an alternative to single nucleotide polymorphism (SNP) arrays as a generic and genome-wide approach for comprehensive preimplantation genetic testing for monogenic disorders (PGT-M), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1229938ce0d6716326966d017670c6
https://cris.maastrichtuniversity.nl/en/publications/f063b5a1-1e6d-47e4-ab82-b9762610e7b5

Age of G-1 PLUS v5 embryo culture medium is inversely associated with birthweight of the newborn

Autor: Sander H.M. Kleijkers, Luc J.M. Smits, Johannes L.H. Evers, Aafke P.A. van Montfoort, Josien G. Derhaag, John C.M. Dumoulin, Edith Coonen

Publikováno v: Human Reproduction, 30(6), 1352-1357. Oxford University Press

Study question Does age of G-1 PLUS v5 embryo culture medium affect IVF outcome? Summary answer Birthweight of singletons born after IVF showed an inverse association with age of the embryo culture medium, while no association was found between age o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb89e43960b81749d77487ce2ce6c23
https://doi.org/10.1093/humrep/dev075

Ammonium accumulation in commercially available embryo culture media and protein supplements during storage at 2-8°C and during incubation at 37°C

Autor: Otto Bekers, Josien G. Derhaag, Edith Coonen, John C.M. Dumoulin, Johannes L.H. Evers, Aafke P.A. van Montfoort, Sander H.M. Kleijkers

Publikováno v: Human reproduction (Oxford, England). 31(6)

Study question Does ammonium accumulate in commercially available culture media and protein supplements used for in vitro development of human pre-implantation embryos during storage and incubation? Summary answer Ammonium accumulates in ready-to-use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a894eb56742015ea727830284a25d396
https://pubmed.ncbi.nlm.nih.gov/27052500

Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos

Autor: Edith Coonen, Marij Janssen, Josien G. Derhaag, M. Bras, John C.M. Dumoulin, Lucie C.P. van Wissen, Joep P.M. Geraedts, Johannes L.H. Evers

Publikováno v: Human Reproduction, 19(2), 316-24. Oxford University Press
Coonen, E, Derhaag, J G, Dumoulin, J C, van Wissen, L J G, Bras, M, Janssen, M H M, Evers, J L & Geraedts, J 2004, ' Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos ', Human Reproduction, vol. 19, no. 2, pp. 316-24 . https://doi.org/10.1093/humrep/deh077

BACKGROUND: Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the chromosomal constitution of human embryos at the blastocyst stage is still rudimentary. ME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e722bf35cfcba38e8b87426cd89f29e0
https://doi.org/10.1093/humrep/deh077