Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Josien C. Haan"'
1
BluePrint breast cancer molecular subtyping recognizes single and dual subtype tumors with implications for therapeutic guidance
Autor: Midas M. Kuilman, Architha Ellappalayam, Andrei Barcaru, Josien C. Haan, Rajith Bhaskaran, Diederik Wehkamp, Andrea R. Menicucci, William M. Audeh, Lorenza Mittempergher, Annuska M. Glas
Publikováno v: Breast Cancer Research and Treatment. 195:263-274
Purpose BluePrint (BP) is an 80-gene molecular subtyping test that classifies early-stage breast cancer (EBC) into Basal, Luminal, and HER2 subtypes. In most cases, breast tumors have one dominant subtype, representative of a single activated pathway
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a8aa44cafb7fc5179ed282464199d6
https://doi.org/10.1007/s10549-022-06698-x
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2
Akademický článek
High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.
Autor: Evert van den Broek, Maurits J J Dijkstra, Oscar Krijgsman, Daoud Sie, Josien C Haan, Joleen J H Traets, Mark A van de Wiel, Iris D Nagtegaal, Cornelis J A Punt, Beatriz Carvalho, Bauke Ylstra, Sanne Abeln, Gerrit A Meijer, Remond J A Fijneman
Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138141 (2015)
Cancer is caused by somatic DNA alterations such as gene point mutations, DNA copy number aberrations (CNA) and structural variants (SVs). Genome-wide analyses of SVs in large sample series with well-documented clinical information are still scarce.
Externí odkaz: https://doaj.org/article/fabc696979d24c22ae1c2ca895da5a61
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3
Akademický článek
Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
Autor: Leonie J M Mekenkamp, Josien C Haan, Daniëlle Israeli, Hendrik F B van Essen, Jeroen R Dijkstra, Patricia van Cleef, Cornelis J A Punt, Gerrit A Meijer, Iris D Nagtegaal, Bauke Ylstra
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e86833 (2014)
The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer prima
Externí odkaz: https://doaj.org/article/b619380266b84ea4a698141d31720e45
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5
Molecular profiles of genomically high risk ER+ HER2- breast cancer tumors classified as functionally basal or luminal B by the 80-gene signature
Autor: Andrea Menicucci, Virginia G. Kaklamani, Carlos A. Encarnacion, Karen L. Tedesco, Robert Maganini, Pat Whitworth, Josien C. Haan, Amy Truitt, Jennifer A. Crozier, Joyce O'Shaughnessy, Rakhshanda Layeequr Rahman, Yuan Yuan, Sami Diab, Julie Barone, William Audeh
Publikováno v: Journal of Clinical Oncology. 39:563-563
563 Background: The 80-gene signature (BluePrint/BP) classifies early-stage breast cancers based on functional molecular pathways as luminal, HER2, or Basal-type. In the NBRST study, 13% of immunochemistry (IHC) defined ER+ HER2- cancers reclassified
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61f5ee2505a8b349124d6dc36c528a17
https://doi.org/10.1200/jco.2021.39.15_suppl.563
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6
Gene expression associated with lymphovascular invasion and genomic risk in early-stage breast cancer
Autor: Josien C. Haan, Nina D'Abreo, William Audeh, Abhinav Rohatgi, Heather M. Kling, Douglas K. Marks
Publikováno v: Journal of Clinical Oncology. 39:559-559
559 Background: Lymphovascular invasion (LVI), the passage of carcinoma cells through lymphatic and blood vessels, is an important early step in metastasis; however, LVI is excluded from most breast cancer (BC) clinical risk assessments. Previous stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c76070c0790d44834fc0e843edab4e5
https://doi.org/10.1200/jco.2021.39.15_suppl.559
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7
Abstract PS18-03: Differential gene expression in luminal-type invasive lobular carcinoma and invasive ductal carcinoma by MammaPrint risk stratification
Autor: Heather M. Kling, Beth-Ann Lesnikoski, Clodia Osipo, Gordan Srkalovic, William Audeh, Patricia A. Robinson, Josien C. Haan, Kaylan Banda, Jennifer A. Crozier
Publikováno v: Cancer Research. 81:PS18-03
Background: Invasive lobular carcinoma (ILC) comprises 10-15% of breast tumors and is the second most common histological type after invasive ductal carcinoma (IDC). Patients with ILC are often diagnosed at an older age and more advanced stage than t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e30f0bffa74226741e169b5868965ac
https://doi.org/10.1158/1538-7445.sabcs20-ps18-03
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8
Abstract PS18-05: Using blueprint to elucidate the molecular heterogeneity of triple negative breast cancers
Autor: Erin Yoder, Lorenza Mittempergher, Karen L. Tedesco, Apurva N. Shah, William Audeh, Abirami Sivapiragasam, Andrea Menicucci, Virginia G. Kaklamani, Michelle L. Bolner, Josien C. Haan, Yuan Yuan, Shiyu Wang, Cathy Graham, Jennifer A. Crozier
Publikováno v: Cancer Research. 81:PS18-05
Background: Triple negative breast cancers (TNBC) are more aggressive, have a worse prognosis, and few targeted therapies compared to other BC subtypes. TNBC is molecularly heterogeneous, with at least 4 distinct subtypes: basal-like immune-activated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::867ed3a6e515c9cd851d89b0c7390b83
https://doi.org/10.1158/1538-7445.sabcs20-ps18-05
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9
Distinct molecular profiles of interval and screen-detected tumors in a real-world breast cancer registry
Autor: William Audeh, Josien C. Haan, Sharon Wilks, Erin Yoder, Kristi McIntyre, Michelina Cairo, Andrea Menicucci, Lorenza Mittempergher, Julie Barone, Linda K. Han, Shiyu Wang
Publikováno v: Journal of Clinical Oncology. 38:e15587-e15587
e15587 Background: Interval breast cancers (BC) are detected between routine screening mammograms and are associated with worse prognosis, requiring more aggressive treatment compared to screen-detected BC identified during scheduled mammograms. Iden
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e13de6a343a9da09cf227c2571618f3
https://doi.org/10.1200/jco.2020.38.15_suppl.e15587
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10
Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer
Autor: James G. Herman, Luc Dehaspe, Sandra Mongera, Nicole C.T. van Grieken, Joost Louwagie, Gerrit A. Meijer, Josien C. Haan, Bauke Ylstra, Linda J.W. Bosch, Petur Snaebjornsson, Miriam Koopman, Tim De Meyer, Geert Trooskens, Matthew T. Seymour, Cornelis J. A. Punt, Iris D. Nagtegaal, Manon van Engeland, Jolien Tol, Wim Van Criekinge, Susan D. Richman, Philip Quirke, Beatriz Carvalho, Henk M.W. Verheul, Veerle M.H. Coupé
Publikováno v: Oncotarget, 8, 38, pp. 63140-63154
ONCOTARGET
Oncotarget, 8, 63140-63154
Oncotarget
Oncotarget, 8(38), 63140-63154. Impact Journals LLC
Oncotarget, 8(38), 63140-63154. Impact Journals
Bosch, L J W, Trooskens, G, Snaebjornsson, P, Coupé, V M H, Mongera, S, Haan, J C, Richman, S D, Koopman, M, Tol, J, Meyer, T D, Louwagie, J, Dehaspe, L, van Grieken, N C T, Ylstra, B, Verheul, H M W, van Engeland, M, Nagtegaal, I D, Herman, J G, Quirke, P, Seymour, M T, Punt, C J A, van Criekinge, W, Carvalho, B & Meijer, G A 2017, ' Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer ', Oncotarget, vol. 8, no. 38, pp. 63140-63154 . https://doi.org/10.18632/oncotarget.18702
Oncotarget, 8(38), 63140. Impact Journals
Contains fulltext : 182283.pdf (Publisher’s version ) (Open Access) Diversity in colorectal cancer biology is associated with variable responses to standard chemotherapy. We aimed to identify and validate DNA hypermethylated genes as predictive bio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93e16b035128395928eac7bca89ae08
https://doi.org/10.18632/oncotarget.18702
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