Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Josie E, Parker"'
Autor:
Jinhong Xie, Jeffrey M. Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methylt
Externí odkaz:
https://doaj.org/article/5bf67aaf3a334a329c3a9686785bf735
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Mohammad Asadzadeh, Wadha Alfouzan, Josie E. Parker, Jacques F. Meis, Steven L. Kelly, Leena Joseph, Suhail Ahmad
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT The molecular basis of reduced susceptibility to amphotericin B (rs-AMB) among any yeasts is poorly defined. Genetic alterations in genes involved in ergosterol biosynthesis and total cell sterols were investigated among clinical Candida kef
Externí odkaz:
https://doaj.org/article/baf9d8e20cba41319bdbbd3ae0696368
Autor:
Jessica Regan, Christian DeJarnette, Arturo Luna-Tapia, Josie E. Parker, Parker Reitler, Stacey Barnett, Katie M. Tucker, Steven L. Kelly, Glen E. Palmer
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The azole antifungals inhibit sterol 14α-demethylase (S14DM), which depletes cellular ergosterol and promotes synthesis of the dysfunctional lipid 14α-methylergosta-8,24(28)-dien-3β,6α-diol, ultimately arresting growth. Mutations that in
Externí odkaz:
https://doaj.org/article/ef3d15f8a1ad4a89b45ba215dd9b1f99
Autor:
Takanori Furukawa, Norman van Rhijn, Marcin Fraczek, Fabio Gsaller, Emma Davies, Paul Carr, Sara Gago, Rachael Fortune-Grant, Sayema Rahman, Jane Mabey Gilsenan, Emma Houlder, Caitlin H. Kowalski, Shriya Raj, Sanjoy Paul, Peter Cook, Josie E. Parker, Steve Kelly, Robert A. Cramer, Jean-Paul Latgé, Scott Moye-Rowley, Elaine Bignell, Paul Bowyer, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primar
Externí odkaz:
https://doaj.org/article/5e2ad52f5b324f87841175e72f74a7dd
Autor:
Claire L Price, Andrew G S Warrilow, Nicola J Rolley, Josie E Parker, Vera Thoss, Diane E Kelly, Nicolae Corcionivoschi, Steven L Kelly
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265227 (2022)
The cytochrome P450 CYP168A1 from Pseudomonas aeruginosa was cloned and expressed in Escherichia coli followed by purification and characterization of function. CYP168A1 is a fatty acid hydroxylase that hydroxylates saturated fatty acids, including m
Externí odkaz:
https://doaj.org/article/0c90bb703fce45e4b14eb43700b54656
Autor:
Tomye L. Ollinger, Bao Vu, Daniel Murante, Josie E. Parker, Lucia Simonicova, Laura Doorley, Mark A. Stamnes, Steven L. Kelly, P. David Rogers, W. Scott Moye-Rowley, Damian J. Krysan
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limi
Externí odkaz:
https://doaj.org/article/104337156c65484e8e5a4480cb3c0aa2
Autor:
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown wh
Externí odkaz:
https://doaj.org/article/57743729eb0c454497ebc0dcd700562d
Autor:
Jeffrey M. Rybak, Katherine S. Barker, José F. Muñoz, Josie E. Parker, Suhail Ahmad, Eiman Mokaddas, Aneesa Abdullah, Rehab S. Elhagracy, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
Clin Microbiol Infect
OBJECTIVE: Candida auris has emerged as a health-care-associated and multidrug-resistant fungal pathogen of great clinical concern. As many as 50% of C. auris clinical isolates are reported to be resistant to amphotericin B, but no mechanisms contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3c856fd34db6f84f7f07fe9090cd21
https://doi.org/10.1016/j.cmi.2021.11.024
https://doi.org/10.1016/j.cmi.2021.11.024
Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
Autor:
Jeffrey M. Rybak, Wenbo Ge, Nathan P. Wiederhold, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Aspergillus fumigatus is the predominant pathogen of invasive aspergillosis, a disease state credited with over 200,000 life-threatening infections each year. The triazole class of antifungals are clinically essential to the treatment of inv
Externí odkaz:
https://doaj.org/article/1a326c478b58433da1a49105ffc817db