Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.

Autor: Katharina B Böndel, Susanne A Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W Ness, Nick Colegrave, Peter D Keightley

Publikováno v: PLoS Biology, Vol 17, Iss 6, p e3000192 (2019)

Spontaneous mutations are the source of new genetic variation and are thus central to the evolutionary process. In molecular evolution and quantitative genetics, the nature of genetic variation depends critically on the distribution of effects of mut

Externí odkaz: https://doaj.org/article/c1b2d612cc7f4a6bb984a236c5c407e8

Prevalence of NTRK Fusions in Canadian Solid Tumour Cancer Patients

Autor: Joshua D. Silvertown, Connie Lisle, Laura Semenuk, Colleen Knapp, Jillann Jaynes, Doreen Berg, Nabodita Kaul, Josianne Lachapelle, Leslie Richardson, Marsha Speevak, Haya Sarras, David M. Berman, Ronald Carter, Harriet Feilotter, Timothy Feltis

Publikováno v: Molecular Diagnosis & Therapy. 27:87-103

Neurotrophic tyrosine receptor kinase (NTRK) gene fusions occur in ~ 0.3% of all solid tumours but are enriched in some rare tumour types. Tropomyosin receptor kinase (TRK) inhibitors larotrectinib and entrectinib are approved as tumour-agnostic ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22ffd2b105688af33ac695cdbb37589
https://doi.org/10.1007/s40291-022-00617-y

The effect of selection history on extinction risk during severe environmental change

Autor: Nick Colegrave, Graham Bell, Josianne Lachapelle

Publikováno v: Journal of Evolutionary Biology. 30:1872-1883

Environments rarely remain the same over time, and populations are therefore frequently at risk of going extinct when changes are significant enough to reduce fitness. Although many studies have investigated what attributes of the new environments an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020726cc44ac24922616d38c3761743d
https://doi.org/10.1111/jeb.13147

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

Autor: Rob W. Ness, Deirdre McClean, Toby Samuels, Peter D. Keightley, Katharina B. Böndel, Susanne A. Kraemer, Nick Colegrave, Josianne Lachapelle

Publikováno v: PLoS Biology, Vol 17, Iss 6, p e3000192 (2019)
PLoS Biology
PLOS Biology
Böndel, K B, Kraemer, S A, Samuels, T, McClean, D, Lachapelle, J, Ness, R W, Colegrave, N & Keightley, P D 2019, ' Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii ', PLoS Biology, vol. 17, no. 6, e3000192 . https://doi.org/10.1371/journal.pbio.3000192

Spontaneous mutations are the source of new genetic variation and are thus central to the evolutionary process. In molecular evolution and quantitative genetics, the nature of genetic variation depends critically on the distribution of effects of mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70b1439dde795a5a5cbc9990c54b7c1
https://doaj.org/article/c1b2d612cc7f4a6bb984a236c5c407e8

Experimental adaptation to marine conditions by a freshwater alga

Autor: Nick Colegrave, Josianne Lachapelle, Graham Bell

Publikováno v: Evolution. 69:2662-2675

The marine-freshwater boundary has been suggested as one of the most difficult to cross for organisms. Salt is a major ecological factor and provides an unequalled range of ecological opportunity because marine habitats are much more extensive than f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01dc504d8126c3f2d18dcdf6331c7783
https://doi.org/10.1111/evo.12760