Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach

Autor: Luciane B. Silva, Elenilze F. B. Ferreira, Maryam, José M. Espejo-Román, Glauber V. Costa, Josiane V. Cruz, Njogu M. Kimani, Josivan S. Costa, José A. H. M. Bittencourt, Jorddy N. Cruz, Joaquín M. Campos, Cleydson B. R. Santos

Publikováno v: Molecules, Vol 28, Iss 3, p 1035 (2023)

Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the hAChE B

Externí odkaz: https://doaj.org/article/dc71a5ccb35141a8b7192fc4f562a8a2

Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening

Autor: Josiane V. Cruz, Moysés F. A. Neto, Luciane B. Silva, Ryan da S. Ramos, Josivan da S. Costa, Davi S. B. Brasil, Cleison C. Lobato, Glauber V. da Costa, José Adolfo H. M. Bittencourt, Carlos H. T. P. da Silva, Franco H. A. Leite, Cleydson B. R. Santos

Publikováno v: Molecules, Vol 23, Iss 2, p 453 (2018)

The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2

Externí odkaz: https://doaj.org/article/954e5774ae6d4a7a9510004fac054c88

An Overview of the α4β1 Integrin and the Potential Therapeutic Role of its Antagonists

Autor: Franco Henrique Andrade Leite, Joaquín M. Campos, Cleydson B. R. Santos, Njogu M. Kimani, Josiane V Cruz, Elenilze F B Ferreira, Pedro H F Araújo, Luciane B. Silva

Publikováno v: Current medicinal chemistry. 28(29)

This article presents a simplified view of integrins with emphasis on the α4 (α4β1/VLA-4) integrin. Integrins are heterodimeric proteins expressed on the cell surface of leukocytes that participate in a wide variety of functions, such as survival,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f1f8b5b17b8e9afadb3a05ace7c8e8
https://pubmed.ncbi.nlm.nih.gov/33596793

Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

Autor: Josivan da Silva Costa, Karina da Silva Lopes Costa, Carlos Henrique Tomich de Paula da Silva, Josiane V Cruz, Davi do Socorro Barros Brasil, Cleydson B. R. Santos, Ryan da Silva Ramos, Luciane B. Silva, Williams Jorge da Cruz Macêdo

Publikováno v: Current Pharmaceutical Design

About 132 thousand cases of melanoma (more severe type of skin cancer) were registered in 2014 according to the World Health Organization. This type of cancer significantly affects the quality of life of individuals. Caffeine has shown potential inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a77d1ac8f8f11266607bb0a3e789d0d
https://doi.org/10.2174/1381612823666170711112510

Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening

Autor: Ryan da Silva Ramos, José Adolfo Homobono Machado Bittencourt, Moysés Fagundes de Araújo Neto, Franco Henrique Andrade Leite, Luciane B. Silva, Carlos Henrique Tomich de Paula da Silva, Josiane V Cruz, Davi do Socorro Barros Brasil, Glauber V da Costa, Cleydson B. R. Santos, Josivan da Silva Costa, Cleison C. Lobato

Publikováno v: Molecules; Volume 23; Issue 2; Pages: 453
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecules, Vol 23, Iss 2, p 453 (2018)

The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d77fe6bc017d81546d78ad5f0aed01a
https://doi.org/10.3390/molecules23020453