Výsledky vyhledávání - "Josiane M. dos Santos"

Synthetic Versatility of β-Alkoxyvinyl Trichloromethyl Ketones for Obtaining [1,2,4]Triazolo[1,5-a]pyrimidines

Autor: Nilo Zanatta, Laura A. Souza, Marcio M. Lobo, Valquiria P. Andrade, Adailton J. Bortoluzzi, Josiane M. dos Santos, Felipe Ribeiro Botelho Santos, Marcos A. P. Martins, Mateus Mittersteiner, Helio G. Bonacorso

Publikováno v: Synthesis. 50:3686-3695

The synthetic versatility of 4-alkoxy-4-alkyl/aryl-1,1,1-trichloroalk-3-en-2-ones (enones) for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines, in which the trichloromethyl group is either maintained or eliminated from the product by simply contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2779950b750cef93bc37e7d147ca8c
https://doi.org/10.1055/s-0037-1610191

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Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones

Autor: Alessandra S. da Silveira, Josiane M. dos Santos, Laura A. Souza, Marcio M. Lobo, Marcos A. P. Martins, Helio G. Bonacorso, Nilo Zanatta

Publikováno v: Synthesis. 47:3947-3955

This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d97c742227b0f68032ecbb900915c75
https://doi.org/10.1055/s-0035-1560470

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Synthesis of 1-Arylethyl-2-arylethylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and Related Compounds with Potential Cell Efflux Pump Inhibition

Autor: Josiane M. dos Santos, Marcos A. P. Martins, Helio G. Bonacorso, Laura A. Souza, Marcio M. Lobo, Valquiria P. Andrade, Nilo Zanatta

Publikováno v: Journal of Heterocyclic Chemistry. 52:1776-1781

This study reports a simple, fast, and efficient method for the synthesis of a new series of 1-arylethyl-2-arylethylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and related compounds from the reaction of 2-alkoxy-5-trifluoroacetyl-3,4-dihydro-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61ce1b29bd3c4c614f54ece99016a968
https://doi.org/10.1002/jhet.2271

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ChemInform Abstract: Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones

Autor: Josiane M. dos Santos, Laura A. Souza, Alessandra S. da Silveira, Helio G. Bonacorso, Marcio M. Lobo, Marcos A. P. Martins, Nilo Zanatta

Publikováno v: ChemInform. 47

The title pyrimidinones are highly regioselectively obtained by cyclocondensation of trichloro-alkenones with non-symmetric substituted isothiourea sulfates under mild basic conditions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e920428d242d2d2ef5ee7470fdc108b0
https://doi.org/10.1002/chin.201618165

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Regioselective synthesis and characterization of new 3-aryl-7-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyrimidines

Autor: Simone S. Amaral, Marcos A. P. Martins, Josiane M. dos Santos, Helio G. Bonacorso, Liana da S. Fernandes, Nilo Zanatta

Publikováno v: Journal of Heterocyclic Chemistry. 48:1085-1090

The regioselective synthesis and characterization of a new series of 3-aryl-7-trifluoromethyl[1,2,4]triazolo[4,3–a]pyrimidines from the oxidative heterocyclization of 2-(N′-benzylidenehydrazino)-4-trifluoromethylpyrimidines with copper dichloride

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb98bede38eb77e554055cf1ab612841
https://doi.org/10.1002/jhet.608

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Synthesis and cytotoxic activity evaluation of some novel 1-(3-(aryl-4,5-dihydroisoxazol-5-yl)methyl)-4-trihalomethyl-1H-pyrimidin-2-ones in human cancer cells

Autor: Simone Schneider Amaral, Cassiana Macagnan Viau, Jenifer Saffi, Josiane M. dos Santos, Marcio M. Lobo, Marcos A. P. Martins, Nilo Zanatta, Helio G. Bonacorso

Publikováno v: European journal of medicinal chemistry. 101

The synthesis of a series of 14 new 1-(3-(aryl-4,5-dihydroisoxazol-5-yl)methyl)-4-trihalomethyl-1H-pyrimidin-2-ones from the 1,3-dipolar cycloaddition reaction of 1-allyl-4-(trihalomethyl)pyrimidin-2(1H)-ones with aryl nitrile oxides is described. Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84629055aaa45bf19476b4ee984e9093
https://pubmed.ncbi.nlm.nih.gov/26275603

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Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

Autor: Marcio M. Lobo, Bruna Canova, Osmar Norberto de Souza, Josiane M. dos Santos, Luis Fernando Saraiva Macedo Timmers, Sara Marchesan Oliveira, Helio G. Bonacorso, Thiago Félix da Silva, Pablo Machado, Indiara Brusco, Marcos A. P. Martins, Nilo Zanatta

Publikováno v: European journal of medicinal chemistry. 102

This study reports a facile and controllable synthetic method for the preparation of both 1,3- and 1,5-isomers of 4-(3(5)-aryl-3(5)-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamides, as well as a new series of 4-(3-aryl-5-hydroxy-5-(trifluorometh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60185f117ed02b877f4d92846cc9d830
https://pubmed.ncbi.nlm.nih.gov/26263246

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New strategy for the synthesis of Bromacil and their analogous

Autor: Marcos A. P. Martins, Nilo Zanatta, Helio G. Bonacorso, Alessandra da Silveira, Josiane M. dos Santos

Publikováno v: Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.

The introduction of halogenes and halogenated groups in organic molecules promotes significant changes in their chemical, physical and biological properties 1 . Halogenation reactions at position 5 of uracils and pyrimidinones has been applied to obt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df182652a1c113913afbe2437904dad1
https://doi.org/10.5151/chempro-15bmos-bmos2013_201371723718

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ChemInform Abstract: New Strategy for the Regioselective Synthesis of 1-Phenyl-3-trifluoromethyl-1H-pyrazoles

Autor: Juliana M. F. M. Schneider, Helio G. Bonacorso, Andreia M. P. W. da Silva, Marcos A. P. Martins, Josiane M. dos Santos, Liana da S. Fernandes, Simone S. Amaral, Nilo Zanatta

Publikováno v: ChemInform. 44

Title compounds (IV) are obtained in a two-step procedure that involves the reaction of enones (I) with hydrazones (II), followed by deprotective hydrolysis and intramolecular nucleophilic heterocyclization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7b3515e8b3360cc54387644f2442310
https://doi.org/10.1002/chin.201344119

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