Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Joshy Jacob"'
Analysis of rare genetic variants in All of Us cohort patients with common variable immunodeficiency
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Common variable immunodeficiency (CVID) is a group of genetic disorders involving more than a dozen genetic loci and characterized by a deficiency in specific antibody isotypes leading to poor immune responses and recurrent infection. CVID affects ap
Externí odkaz:
https://doaj.org/article/0b2a077a62264057a8ec2241c8696863
Autor:
Ian M. Bird, Victoria Cavener, Meera Surendran Nair, Ruth H. Nissly, Shubhada K. Chothe, Joshy Jacob, Suresh V. Kuchipudi
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1840 (2024)
Zika virus (ZIKV), a mosquito-borne flavivirus, is a significant global health concern due to its association with neurodevelopmental disorders such as congenital Zika syndrome (CZS). This study aimed to compare the replication kinetics, viral persis
Externí odkaz:
https://doaj.org/article/61a2e15d38494c5a870405e7296dbd38
Autor:
Troy von Beck, Karla Navarrete, Nicholas A. Arce, Mu Gao, Gordon A. Dale, Meredith E. Davis-Gardner, Katharine Floyd, Luis Mena Hernandez, Nikita Mullick, Abigail Vanderheiden, Ioanna Skountzou, Suresh V. Kuchipudi, Rathi Saravanan, Renhao Li, Jeffrey Skolnick, Mehul S. Suthar, Joshy Jacob
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a clear threat to humanity. It has infected over 200 million and killed 4 million people worldwide, and infections continue with no end in sight. To control the pandemic,
Externí odkaz:
https://doaj.org/article/e02836828324427c886174a79b6c8fa8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Following SARS-CoV-2 infection, some COVID-19 patients experience severe host driven adverse events. To treat these complications, their underlying etiology and drug treatments must be identified. Thus, a novel AI methodology MOATAI-VIR, whi
Externí odkaz:
https://doaj.org/article/6d5dfd9b8b304382b1be356f12281eba
Autor:
Troy von Beck, Luis Mena Hernandez, Hongyi Zhou, Katharine Floyd, Mehul S. Suthar, Jeffrey Skolnick, Joshy Jacob
Publikováno v:
Viruses, Vol 15, Iss 9, p 1841 (2023)
The emergence of SARS-CoV-1 in 2003 followed by MERS-CoV and now SARS-CoV-2 has proven the latent threat these viruses pose to humanity. While the SARS-CoV-2 pandemic has shifted to a stage of endemicity, the threat of new coronaviruses emerging from
Externí odkaz:
https://doaj.org/article/a1285da037324ab1a67d17ece6733ca5
Autor:
Vasilis C. Pliasas, Zach Menne, Virginia Aida, Ji-Hang Yin, Maria C. Naskou, Peter J. Neasham, J. Fletcher North, Dylan Wilson, Katharine A. Horzmann, Joshy Jacob, Ioanna Skountzou, Constantinos S. Kyriakis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Influenza A viruses (IAVs) pose a global health threat, contributing to hundreds of thousands of deaths and millions of hospitalizations annually. The two major surface glycoproteins of IAVs, hemagglutinin (HA) and neuraminidase (NA), are important a
Externí odkaz:
https://doaj.org/article/b5286a2cc61a4bf98f80d2cd6dd5e441
Autor:
Abhiman Das, Anurag K. Agarwal, Joshy Jacob, Sanket Mohapatra, Saket Hishikar, Saakshi Bangar, Sandeep Parekh, Sudarshana Basu, U. K. Sinha
Publikováno v:
Vikalpa, Vol 45 (2022)
Externí odkaz:
https://doaj.org/article/c70324d340944148aa2c0b5da52ece09
Autor:
Song Hee Lee, Eui Ho Kim, Justin T. O’neal, Gordon Dale, David J. Holthausen, James R. Bowen, Kendra M. Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S. Suthar, Joshy Jacob
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus
Externí odkaz:
https://doaj.org/article/1222b054c19b4f9b953994df1b0439c9
Publikováno v:
Vikalpa, Vol 45 (2020)
Externí odkaz:
https://doaj.org/article/649cb524f1e34d83bb9de0145ec835d0
Autor:
Eui Ho Kim, Matthew C Woodruff, Lilit Grigoryan, Barbara Maier, Song Hee Lee, Pratyusha Mandal, Mario Cortese, Muktha S Natrajan, Rajesh Ravindran, Huailiang Ma, Miriam Merad, Alexander D Gitlin, Edward S Mocarski, Joshy Jacob, Bali Pulendran
Publikováno v:
eLife, Vol 9 (2020)
The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both seasonal and pandemic influenza vaccines. Despite its wide use and efficacy, its mechanisms o
Externí odkaz:
https://doaj.org/article/e62364c0766c48fdad9fa823a8b76041