Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joshua Yoder"'
Distortion Product Otoacoustic Emission Test is Not the Test to Use in Nonclinical Safety Assessment
Publikováno v:
International journal of toxicology. 41(3)
Ototoxicity and ocular toxicity screening are but two examples of specialty product lines that are often employed as Tier II or III nonclinical safety/hazard screening assessments. Compared to the regulatory guidelines that govern over standard toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8803b88073130ed7d2276ff754d38349
https://pubmed.ncbi.nlm.nih.gov/35443823
https://pubmed.ncbi.nlm.nih.gov/35443823
Publikováno v:
International Journal of Toxicology. 37:422-433
Spontaneous unexpected events occasionally develop during the course of rodent preclinical toxicology studies. The presentation of serious adverse events on animal studies may require notification of these events to the Food and Drug Administration i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3337bfb95a01d0dea7ab05fce286a655
https://doi.org/10.1177/1091581818796444
https://doi.org/10.1177/1091581818796444
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:123-129
There are three major assays that must be conducted in standard investigational new drug (IND) -enabling ototoxicity study designs: 1) functional acoustic threshold measurements (Auditory Brainstem Respsonse, ABR); 2) otohistopathology and 3) cytococ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bd3b0510a0a137672b449ac6320134
https://doi.org/10.1016/j.vascn.2017.09.254
https://doi.org/10.1016/j.vascn.2017.09.254
Publikováno v:
International journal of toxicology. 38(4)
History has established that many drugs, such as the antibiotics, chemotherapies, and loop diuretics, are capable of inducing both nephrotoxicity and ototoxicity. The exact mechanisms by which cellular damage occurs remain to be fully elucidated. Mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e942c9f872f047e4b5740037814edd1
https://pubmed.ncbi.nlm.nih.gov/31220989
https://pubmed.ncbi.nlm.nih.gov/31220989
Publikováno v:
Otolaryngology - Open Journal. 2:58-69
Introduction: Ototoxicity has been defined as the tendency of certain therapeutic agents and other chemical substances to cause functional impairments and cellular degeneration of the tissues of the inner ear resulting in hearing loss. Objectives: Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f70dd9902bfc153dcfd2d297fc881fa
https://doi.org/10.17140/otloj-2-114
https://doi.org/10.17140/otloj-2-114
Autor:
David V. Gauvin, Joshua Yoder, Jill A. Dalton, Theodore J. Baird, Zachary J. Zimmermann, Mary Jeanne Kallman
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106716
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ab8994df979da7e8f5e611b5ad8fbaf
https://doi.org/10.1016/j.vascn.2020.106716
https://doi.org/10.1016/j.vascn.2020.106716
Autor:
Mary Jeanne Kallman, Joshua Yoder, David V. Gauvin, Jill A. Dalton, Theodore J. Baird, Zachary J. Zimmermann
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106837
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a083b2f0d8d35d0f22dbe8008101d4f
https://doi.org/10.1016/j.vascn.2020.106837
https://doi.org/10.1016/j.vascn.2020.106837
Autor:
Jill A. Dalton, Zachary J. Zimmermann, David V. Gauvin, Marci Harter, Theodore J. Baird, Quinn Kilgus, Jonelle May, Joshua Yoder, David L. Holdsworth
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 1)
Three significant contributions to the field of safety pharmacology were recently published detailing the use of electroencephalography (EEG) by telemetry in a critical role in the successful evaluation of a compound during drug development (1] Authi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2d652f8f668eec14fc9fc5591207a
https://pubmed.ncbi.nlm.nih.gov/29751085
https://pubmed.ncbi.nlm.nih.gov/29751085
Publikováno v:
Pharmaceutical Regulatory Affairs: Open Access.
Federally unregulated, marijuana growth organizations (MGOs) have now provided a path to exposures to the neurotoxicity of heavy metals. The lack of US Food and Drug Administration (FDA) and US Environmental Protection Agency (EPA) testing and oversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b1ba4e2417db58f8203c890ec828415
https://doi.org/10.4172/2167-7689.1000202
https://doi.org/10.4172/2167-7689.1000202
Publikováno v:
International journal of toxicology. 36(1)
Life experiences, industrial/environmental exposures, and administration of Food and Drug Administration (FDA)-approved drugs may have unintended but detrimental effects on peripheral and central auditory pathways. Most relevant to the readership of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eff0a09213e8c883b08360c9b14b19
https://pubmed.ncbi.nlm.nih.gov/27194512
https://pubmed.ncbi.nlm.nih.gov/27194512