A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.

Autor: Tara K Sigdel, Joshua Y C Yang, Oriol Bestard, Andrew Schroeder, Szu-Chuan Hsieh, Juliane M Liberto, Izabella Damm, Anna C M Geraedts, Minnie M Sarwal

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0220052 (2019)

A Common Rejection Module (CRM) consisting of 11 genes expressed in allograft biopsies was previously reported to serve as a biomarker for acute rejection (AR), correlate with the extent of graft injury, and predict future allograft damage. We invest

Externí odkaz: https://doaj.org/article/8c215c1f023a43c2acb313613b4caa72

Non-radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay

Autor: Thomas Chi, Joshua Y. C. Yang, Karina Ky, Minnie M. Sarwal, Vivian Dong, Reuben D. Sarwal, Marshall L. Stoller

Publikováno v: BJU International. 125:732-738

OBJECTIVES To evaluate the utility of kidney injury test (KIT) assay urinary biomarkers to detect kidney stones and quantify stone burden. PATIENTS AND METHODS A total of 136 spot urine samples from 98 individuals, with and without kidney stone disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819f412327fe43c2525ab621a06f4095
https://doi.org/10.1111/bju.14978

Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients

Autor: Juliane Liberto, Minnie M. Sarwal, Reuben D. Sarwal, Tara K. Sigdel, Andrew Schroeder, Joshua Y. C. Yang

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 8
Journal of Clinical Medicine, Vol 9, Iss 2341, p 2341 (2020)
Journal of clinical medicine, vol 9, iss 8

Despite new advancements in surgical tools and therapies, exposure to immunosuppressive drugs related to non-immune and immune injuries can cause slow deterioration and premature failure of organ transplants. Diagnosis of these injuries by non-invasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2e493d0b061d4f1b1e35776dd3baf0

Transplant genetics and genomics

Autor: Joshua Y. C. Yang, Minnie M. Sarwal

Publikováno v: Nature Reviews Genetics. 18:309-326

Ever since the discovery of the major histocompatibility complex, scientific and clinical understanding in the field of transplantation has been advanced through genetic and genomic studies. Candidate-gene approaches and recent genome-wide associatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f525db30a338a002fa433519a5df6f69
https://doi.org/10.1038/nrg.2017.12

A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection

Autor: José M. Arreola-Guerra, Joshua Y. C. Yang, Josefina Alberú, Ben Rosenbaum, Juliane Liberto, Reuben D. Sarwal, Tara K. Sigdel, Flavio Vincenti, Izabella Damm, Chitranon Chan-on, Minnie M. Sarwal

Publikováno v: Sci Transl Med

Accurate and noninvasive monitoring of renal allograft posttransplant is essential for early detection of acute rejection (AR) and to affect the long-term survival of the transplant. We present the development and validation of a noninvasive, spot ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93df11c0ad619266d1e79079a4edcd3
https://pubmed.ncbi.nlm.nih.gov/32188722