Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joshua Walum"'
Autor:
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway inflammation,
Externí odkaz:
https://doaj.org/article/d2df94ebcca34c6e80606f05eb9717af
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Type 2-high severe asthma is described as a distinct endotype with Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. While the inflammatory milieu is similar to mild asthma, patients
Externí odkaz:
https://doaj.org/article/58ce66a881434b29844e4ebaaada7c70
Autor:
Stephanie A. Amici, Brandon W Lewis, Joshua A. Englert, Aiman Khan, Mireia Guerau-de-Arellano, Kymberly M Gowdy, Rodney D. Britt, Emily M. Shalosky, Joshua Walum, Michell H Grayson, Hye-Young H. Kim, Ned A. Porter
Publikováno v:
J Immunol
Severe asthma is characterized by steroid insensitivity and poor symptom control and is responsible for most asthma-related hospital costs. Therapeutic options remain limited, in part due to limited understanding of mechanisms driving severe asthma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a9bf862b714439e4fc4d8201fda0b4
https://europepmc.org/articles/PMC9055570/
https://europepmc.org/articles/PMC9055570/
Autor:
D. Jackson, Mieria Guerau-de-Arellano, Rodney D. Britt, Manel Guessas, Stephanie A. Amici, Mitchell H. Grayson, Sonia Guessas, B.W. Lewis, Joshua Walum, Akhila V Boda, Elise Coneglio
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 321(6)
Corticosteroid insensitivity in asthma limits the ability to effectively manage severe asthma, which is characterized by persistent airway inflammation, airway hyperresponsiveness (AHR), and airflow obstruction despite corticosteroid treatment. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5be66ee4e6aeaec8debe103d5205574
https://pubmed.ncbi.nlm.nih.gov/34755542
https://pubmed.ncbi.nlm.nih.gov/34755542
Autor:
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Publikováno v:
Respiratory research. 23(1)
Background Corticosteroids remain a key therapy for treating children with asthma. Patients with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly controlled symptoms that involve airway inflammation, airflow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3de28b38fb5f483eae7c31ae43fd935
https://pubmed.ncbi.nlm.nih.gov/35578269
https://pubmed.ncbi.nlm.nih.gov/35578269