Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Joshua W.K. Ho"'
Autor:
Julie Warin, Nicolas Vedrenne, Vivian Tam, Mengxia Zhu, Danqing Yin, Xinyi Lin, Bluwen Guidoux-D’halluin, Antoine Humeau, Luce Roseiro, Lily Paillat, Claire Chédeville, Caroline Chariau, Frank Riemers, Markus Templin, Jérôme Guicheux, Marianna A. Tryfonidou, Joshua W.K. Ho, Laurent David, Danny Chan, Anne Camus
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109018- (2024)
Summary: Understanding the emergence of human notochordal cells (NC) is essential for the development of regenerative approaches. We present a comprehensive investigation into the specification and generation of bona fide NC using a straightforward p
Externí odkaz:
https://doaj.org/article/4fbbade5e5f24b0385edeacb652fc23d
Autor:
Shichao Ma, Xiunan Fang, Yu Yao, Jianfu Li, Daniel C. Morgan, Yongyan Xia, Crystal S.M. Kwok, Michelle C.K. Lo, Dickson M.D. Siu, Kevin K. Tsia, Andrian Yang, Joshua W.K. Ho
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1598-1605 (2023)
Current single-cell visualisation techniques project high dimensional data into ‘map’ views to identify high-level structures such as cell clusters and trajectories. New tools are needed to allow the transversal through the high dimensionality of
Externí odkaz:
https://doaj.org/article/145afd5c29ed4942a64bb0cb3357ce35
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106881- (2023)
Summary: Mass spectrometry (MS)-based untargeted metabolomic and lipidomic approaches are being used increasingly in biomedical research. The adoption and integration of these data are critical to the overall multi-omic toolkit. Recently, a sample ex
Externí odkaz:
https://doaj.org/article/0562295b8e8f4165bbc10f13facc34a8
Autor:
Ralph Patrick, David T. Humphreys, Vaibhao Janbandhu, Alicia Oshlack, Joshua W.K. Ho, Richard P. Harvey, Kitty K. Lo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing overall expression levels, largely ignoring alternative mRNA isof
Externí odkaz:
https://doaj.org/article/b63da871092f462faa34bf435f39a886
Autor:
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucía Fernández-del-Rio, Sergey Tumanov, Stephanie MY. Kong, Jelske N. van der Veen, Andrian Yang, Joshua W.K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, René L. Jacobs, Roland Stocker
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102127- (2021)
Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a rang
Externí odkaz:
https://doaj.org/article/e5e37048d10e4f0db080cc6d7d4696a3
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101190- (2021)
Printing single cells into individual chambers is of critical importance for single-cell analysis using traditional equipment, for instance, single-cell clonal expansion or sequencing. The size of cells can usually be a reflection of their types, fun
Externí odkaz:
https://doaj.org/article/000ba37204b24d779516b78210db0090
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 15, Iss , Pp 379-386 (2017)
This review examines two important aspects that are central to modern big data bioinformatics analysis – software scalability and validity. We argue that not only are the issues of scalability and validation common to all big data bioinformatics an
Externí odkaz:
https://doaj.org/article/989798578514480aa8cd30705facd4e5
Autor:
Jennifer E. Cropley, Sally A. Eaton, Alastair Aiken, Paul E. Young, Eleni Giannoulatou, Joshua W.K. Ho, Michael E. Buckland, Simon P. Keam, Gyorgy Hutvagner, David T. Humphreys, Katherine G. Langley, Darren C. Henstridge, David I.K. Martin, Mark A. Febbraio, Catherine M. Suter
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 699-708 (2016)
Objective: Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed t
Externí odkaz:
https://doaj.org/article/e750315967c34129a01c1104d440a993
Autor:
Andrian Yang, Dimuthu Alankarage, Hartmut Cuny, Eddie K.K. Ip, Moran Almog, Jessica Lu, Debjani Das, Annabelle Enriquez, Justin O. Szot, David T. Humphreys, Gillian M. Blue, Joshua W.K. Ho, David S. Winlaw, Sally L. Dunwoodie, Eleni Giannoulatou
Publikováno v:
Circulation: Genomic and Precision Medicine. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e7f54b93899b8913377970d78957fc
https://doi.org/10.1161/circgen.121.003539
https://doi.org/10.1161/circgen.121.003539
Autor:
Weizhong Zheng, John H.C. Fong, Yuk Kei Wan, Athena H.Y. Chu, Yuanhua Huang, Alan S.L. Wong, Joshua W.K. Ho
Many studies have found that sequence in the 5’ untranslated regions (UTRs) impacts the translation rate of an mRNA, but the regulatory grammar that underpins this translation regulation remains elusive. Deep learning methods deployed to analyse ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1b52aed0c38983b4e99481178ea78d
https://doi.org/10.1101/2022.05.03.490410
https://doi.org/10.1101/2022.05.03.490410
