Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joshua W. Henshaw"'
Autor:
Kevin Hammon, Greg deHart, Brian R. Vuillemenot, Derek Kennedy, Don Musson, Charles A. O’Neill, Martin L. Katz, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1810-1821 (2021)
Abstract Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an ultra‐rare pediatric neurodegenerative disorder characterized by deficiency of the lysosomal enzyme tripeptidyl peptidase‐1 (TPP1). In the absence of adequate TPP1, lysosomal sto
Externí odkaz:
https://doaj.org/article/0b3f82eee32841929b398938b7d967e2
Autor:
Aryun Kim, Anita Grover, Kevin Hammon, Greg deHart, Peter Slasor, Anu Cherukuri, Temitayo Ajayi, David Jacoby, Angela Schulz, Nicola Specchio, Emily deLos Reyes, Paul Gissen, Joshua W. Henshaw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 635-644 (2021)
Cerliponase alfa is recombinant human tripeptidyl peptidase 1 (TPP1) delivered by i.c.v. infusion for CLN2, a pediatric neurodegenerative disease caused by deficiency in lysosomal enzyme TPP1. We report the pharmacokinetics (PK) and pharmacodynamics
Externí odkaz:
https://doaj.org/article/afb882a5970146d6bafd1acb5b2b22cf
Autor:
Zev A. Wainberg, Lauren Averett Byers, Nicola J. Curtin, Miranda Patterson, Ashleigh Herriott, Joshua W. Henshaw, David C. Smith, John Heymach, Jasgit Sachdev, Stan Kaye, Saeed Rafii, John Glaspy, Rashmi Chugh, Lida Mina, Ramesh K. Ramanathan, Johann de Bono
Supplementary Figure S1. Talazoparib inhibition of PBMC PARP activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e95db2be5b81e9a0f3ad86b8281bd1
https://doi.org/10.1158/2159-8290.22531110
https://doi.org/10.1158/2159-8290.22531110
Autor:
Zev A. Wainberg, Lauren Averett Byers, Nicola J. Curtin, Miranda Patterson, Ashleigh Herriott, Joshua W. Henshaw, David C. Smith, John Heymach, Jasgit Sachdev, Stan Kaye, Saeed Rafii, John Glaspy, Rashmi Chugh, Lida Mina, Ramesh K. Ramanathan, Johann de Bono
Supplementary Methods includes additional details on these topics: tumors eligible for dose escalation phase; tumors eligible for dose expansion phase; patients enrolled using a local laboratory; study design and participants; additional inclusion cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c35bb32f493e71bbc643b22bb0b3649
https://doi.org/10.1158/2159-8290.22531107.v1
https://doi.org/10.1158/2159-8290.22531107.v1
Autor:
Zev A. Wainberg, Lauren Averett Byers, Nicola J. Curtin, Miranda Patterson, Ashleigh Herriott, Joshua W. Henshaw, David C. Smith, John Heymach, Jasgit Sachdev, Stan Kaye, Saeed Rafii, John Glaspy, Rashmi Chugh, Lida Mina, Ramesh K. Ramanathan, Johann de Bono
Supplementary Table S1. Dose-response and exposure-response parameters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b99fccdd412f6f65d1dfdcba0f9d8d0
https://doi.org/10.1158/2159-8290.22531104
https://doi.org/10.1158/2159-8290.22531104
Publikováno v:
Cancer gene therapy
Pulsed electric fields can enhance interstitial transport of plasmid DNA (pDNA) in solid tumors. However, the extent of enhancement is still limited. To this end, the effects of cellular resistance to electric field-mediated gene delivery were invest
Publikováno v:
Molecular Cancer Therapeutics. 7:2566-2573
Pulsed electric fields have been shown to enhance interstitial transport of plasmid DNA (pDNA) in solid tumors in vivo. However, the extent of enhancement is still limited partly due to the collagen component in extracellular matrix. To this end, eff
Publikováno v:
Bioelectrochemistry. 69:248-253
The interstitial space is a rate limiting physiological barrier to non-viral gene delivery. External pulsed electric fields have been proposed to increase DNA transport in the interstitium, thereby improving non-viral gene delivery. In order to chara
Pulsed electric field has been widely used as a nonviral gene delivery platform. The delivery efficiency can be improved through quantitative analysis of pore dynamics and intracellular transport of plasmid DNA. To this end, we investigated mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a801cec349465b56c75d6b35c20dda
https://europepmc.org/articles/PMC2782745/
https://europepmc.org/articles/PMC2782745/
Autor:
Joshua W. Henshaw, Fan Yuan
Publikováno v:
Journal of pharmaceutical sciences. 97(2)
Gene therapy has a great potential in cancer treatment. However, the efficacy of cancer gene therapy is currently limited by the lack of a safe and efficient means to deliver therapeutic genes into the nucleus of tumor cells. One method under investi