Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants.

Autor: Kailiang Sun, Jakub Orzechowski Westholm, Kazuya Tsurudome, Joshua W Hagen, Yubing Lu, Minoree Kohwi, Doron Betel, Fen-Biao Gao, A Pejmun Haghighi, Chris Q Doe, Eric C Lai

Publikováno v: PLoS Genetics, Vol 8, Iss 2, p e1002515 (2012)

miR-124 is conserved in sequence and neuronal expression across the animal kingdom and is predicted to have hundreds of mRNA targets. Diverse defects in neural development and function were reported from miR-124 antisense studies in vertebrates, but

Externí odkaz: https://doaj.org/article/2dc79ea36ad24fe7bab34e6b25d87eba

Nonmelanoma Skin Cancer Risk in Patients With Inflammatory Bowel Disease Undergoing Thiopurine Therapy: A Systematic Review of the Literature

Autor: Melissa Pugliano-Mauro, Joshua W. Hagen

Publikováno v: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 44(4)

Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc0df0637c8b343162bd064c8a6546b
https://pubmed.ncbi.nlm.nih.gov/29315147

Emerging Adverse Cutaneous Drug Reactions

Autor: Joshua W. Hagen, A. Neil Crowson, Cynthia M. Magro

Publikováno v: Dermatologic Clinics. 30:695-730

The past several decades have seen the advent and rapidly expanding use of biological agents in the treatment of chronic disease states. As increasingly large pools of patients have been enrolled in treatment protocols using these agents, physicians

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb351d9710ea295d4d40d2ff2e20e08
https://doi.org/10.1016/j.det.2012.06.016

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci

Autor: Joshua W. Hagen, Wei Jen Chung, Gregory J. Hannon, Eugene Berezikov, David M. Tyler, Katsutomo Okamura, Eric C. Lai

Publikováno v: Genes and Development, 22(1), 26-36. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Genes & Development, 22(1), 26-36. Cold Spring Harbor Laboratory Press

Many microRNA (miRNA) loci exhibit compelling hairpin structures on both sense and antisense strands; however, the possibility that a miRNA gene might produce functional species from its antisense strand has not been examined. We report here that ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475ce33495f3084c0cfaa43bdd685ecb
https://doi.org/10.1101/gad.1615208

Hypopigmented interface T-cell dyscrasia: a form of cutaneous T-cell dyscrasia distinct from hypopigmented mycosis fungoides

Autor: Joshua W. Hagen, Yen Chen Liu, Natalie M. Drucker, Cynthia M. Magro, Martin C. Mihm, Aminah H. Yassin, A. N. Crowson

Publikováno v: The Journal of dermatology. 41(7)

Hypopigmentation in cutaneous T-cell lymphoproliferative disease should not always be equated with hypopigmented mycosis fungoides (MF). A form of hypopigmented pre-lymphomatous T-cell dyscrasia falling under the designation of the so-called hypopigm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ce7ad4312da703fa6ce7e95286ee38
https://pubmed.ncbi.nlm.nih.gov/24806661