Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joshua Taygerly"'
Autor:
Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate in
Externí odkaz:
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Paul A. Barsanti, Joshua Taygerly, Kathleen Boyle, Kyle R. Simonetta, Stephanie L. Yung, Szerenke Kiss von Soly, Chris Padovani, Frank Kayser, Neil Bence, Anjanabha Saha, Stephen E. Basham, John Kuriyan, Mark Gallop, Thomas Cummins, Yan Lou, Michael Rape, Mario G. Cardozo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Nature Communications
Nature communications, vol 10, iss 1
Simonetta, Kyle R; Taygerly, Joshua; Boyle, Kathleen; Basham, Stephen E; Padovani, Chris; Lou, Yan; et al.(2019). Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.. Nature communications, 10(1), 1402. doi: 10.1038/s41467-019-09358-9. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/26s7m3b9
Protein–protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. There is significant therapeutic potential in the development of small molecules that modulate these interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d19fdea334a0af8bb97cc6bfba60718
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Jia-Nan Gong, Angela Coxon, Sean Caenepeel, Cyril H. Benes, Andrew W. Roberts, Tao Osgood, Donia M Moujalled, Elaina Cajulis, Andrew H. Wei, Regina K. Egan, Mario G. Cardozo, Pedro J. Beltran, Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Brian Lucas, Xin Huang, Gordon Moody, Paul E. Hughes, David C.S. Huang, Giovanna Pomilio, Joshua Taygerly, Jan Sun, Danny Chui, Leszek Poppe, Jude Canon, Douglas A. Whittington, Yunxiao Li, Manuel Zancanella, Nick A. Paras, Joseph McClanaghan, Xianghong Wang, Alan C. Cheng, Kathleen S. Keegan, Jonathan B. Houze, Leah J. Damon, Patricia Greninger, Brian Belmontes
Publikováno v:
Cancer discovery. 8(12)
The prosurvival BCL2 family member MCL1 is frequently dysregulated in cancer. To overcome the significant challenges associated with inhibition of MCL1 protein–protein interactions, we rigorously applied small-molecule conformational restriction, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecf4086e51963a2ef56014b0508efb2
https://pubmed.ncbi.nlm.nih.gov/31262746
https://pubmed.ncbi.nlm.nih.gov/31262746
Autor:
Marc Learned, Steven M. Rubenstein, Juan C. Jaen, Hisashi Shinkai, Jun Nishiu, Holger Beckmann, Alykhan Motani, Jin-Long Chen, Yuki Kitao, Lawrence R. McGee, Martin Thoolen, Patrick C. Kearney, Yang Li, Atsushi Hagiwara, Jinsong Liu, Guosen Ye, Michelle Lindstrom, Timothy D. Cushing, Joshua Taygerly, John A. Flygare, Nigel Walker, Jennifer Weiszmann, Tetsuya Iida, Walter P. Frankmoelle, Zhulun Wang, Shichang Miao, Hisateru Aramaki, Pieter B. M. W. M. Timmermans, Noboru Furukawa, Jonathan B. Houze, Donna H.T. Biermann, Motonao Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:979-992
PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of a novel chemical class of diarylsulfonamide partial agonists that act as selective PPARγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdec54bdc6f85c8e2a8785ec784731f5
https://doi.org/10.1016/j.bmc.2012.11.058
https://doi.org/10.1016/j.bmc.2012.11.058
Autor:
Joshua Taygerly, Thomas Cummins
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293235
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87cda6f4cbe6eddf55b2169e30c8ae4c
https://doi.org/10.29200/acsmedchemrev-v51.ch4
https://doi.org/10.29200/acsmedchemrev-v51.ch4
Autor:
Sean P. Brown, Joshua Taygerly
GPR40 (also known as FFA1) is a G-protein-coupled receptor primarily expressed in pancreatic islets and enteroendocrine cells, and activation of GPR40 has been shown to stimulate insulin secretion through a glucose-dependent mechanism. For this reaso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3dac8ce62d97b0546094c67fb48d87
https://doi.org/10.1016/b978-0-12-800167-7.00006-7
https://doi.org/10.1016/b978-0-12-800167-7.00006-7
Autor:
Sean P. Brown, Joshua Taygerly
The Bcl-2 family of proteins is central to regulating apoptosis, and selective inhibition of Bcl-2 family proteins has been shown to be a promising strategy for the treatment of cancer. Several small-molecule Bcl-2 family inhibitors are currently pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e1d11df10c40eb5cedc8c8e38b36cd
https://doi.org/10.1016/b978-0-12-396492-2.00017-5
https://doi.org/10.1016/b978-0-12-396492-2.00017-5
Publikováno v:
Green Chemistry. 14:3020
One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1cca384eedb11a7fc2f0bf81146f43
https://doi.org/10.1039/c2gc36064k
https://doi.org/10.1039/c2gc36064k