Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joshua T. Wolfe"'
Autor:
Jessica S. Dymond, Brant W. Chee, Corban G. Rivera, Joseph Downs, Claire Marie Filone, Craig Howser, Miller Wilt, Joshua T. Wolfe
Advances in genome editing and gene synthesis technologies have increased the ease with which biological agents can be engineered. Existing methods to identify the engineering source are insufficient for attribution. We hypothesized that strategies u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a6e78d9088916d07773461b2d3496b
Autor:
Thomas J. Smith, Peter Thielen, Naiwen Cui, Adrian W.R. Serohijos, Nicholas S. Giacobbi, James M. Pipas, Jeffrey S. Lin, Susan Wu, Jeong-Mo Choi, Thomas Mehoke, Hua Zhang, David A. Weitz, Lloyd W. Ung, Ye Tao, Audrey Fischer, João V. Rodrigues, Joshua T. Wolfe, Andrew B. Feldman, Eugene I. Shakhnovich, Abimbola O. Kolawole, Connie B. Chang, Stephan A. Koehler, Plamen A. Demirev, Kellogg J. Schwab, Timothy R. Julian, Assaf Rotem, Christiane E. Wobus
Publikováno v:
Molecular Biology and Evolution
Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the landscape and the evolutionary forces on it remain elusive. Here, we apply a biophysical fitness mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0f479e2ee679ad27ce0dc79d5630c0
https://pubmed.ncbi.nlm.nih.gov/29955873
https://pubmed.ncbi.nlm.nih.gov/29955873
Autor:
William F. Fagan, Eric V. Slud, Peter Thielen, Joshua T. Wolfe, Sharon Bewick, Florian P. Breitwieser, Shishir Paudel, Thomas Mehoke, Arjun Adhikari, David K. Karig, Kumar P. Mainali
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0187132 (2017)
PLoS ONE, Vol 12, Iss 11, p e0187132 (2017)
Drawing on a long history in macroecology, correlation analysis of microbiome datasets is becoming a common practice for identifying relationships or shared ecological niches among bacterial taxa. However, many of the statistical issues that plague s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2a3d61182745d6798b35f89acc9926
http://europepmc.org/articles/PMC5689832
http://europepmc.org/articles/PMC5689832
Autor:
Lloyd W. Ung, Ye Tao, Susan Wu, David A. Weitz, Eugene I. Shakhnovich, Assaf Rotem, Plamen A. Demirev, Thomas J. Smith, Thomas Mehoke, Jeffrey S. Lin, Stephan A. Koehler, Christiane E. Wobus, Naiwen Cui, Adrian W.R. Serohijos, Nicholas S. Giacobbi, Kellogg J. Schwab, Audrey Fischer, Joshua T. Wolfe, Abimbola O. Kolawole, Timothy R. Julian, James M. Pipas, Andrew B. Feldman, Peter Thielen, Connie B. Chang, Hua Zhang, Jeong-Mo Choi
Predicting viral evolution remains a major challenge with profound implications for public health. Viral evolutionary pathways are determined by the fitness landscape, which maps viral genotype to fitness. However, a quantitative description of the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4096bf5303e8504c6c51ef5734d46410
https://doi.org/10.1101/090258
https://doi.org/10.1101/090258
Many biotechnology capabilities are limited by stringent storage needs of reagents, largely prohibiting use outside of specialized laboratories. Focusing on a large class of protein-based biotechnology applications, we address this issue by developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc107cd32c3ea3e27657d5ad96d9892
https://doi.org/10.1101/089664
https://doi.org/10.1101/089664
Publikováno v:
Journal of Biological Chemistry. 280:39417-39422
Protective antigen (PA) of anthrax toxin binds cellular receptors and forms pores in target cell membranes, through which catalytic lethal factor (LF) and edema factor (EF) are believed to translocate to the cytoplasm. Using patch clamp electrophysio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6569dedcc43d5016e4115af690044cb
https://doi.org/10.1074/jbc.m509049200
https://doi.org/10.1074/jbc.m509049200
Publikováno v:
The Journal of Physiology. 538:343-355
Molecular cloning of low-voltage activated (LVA) T-type calcium channels has enabled the study of their regulation in heterologous expression systems. Here we investigate the regulation of Ca(v)3.2 alpha(1)-subunits (alpha1H) by calcium- and/or calmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3100f83949df6f7c90e9a15762c9bc86
https://doi.org/10.1113/jphysiol.2001.012839
https://doi.org/10.1113/jphysiol.2001.012839
Publikováno v:
Journal of the Royal Society Interface
Many biotechnology capabilities are limited by stringent storage needs of reagents, largely prohibiting use outside of specialized laboratories. Focusing on a large class of protein-based biotechnology applications, we address this issue by developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2617c5a3d79c6e22f79c2c4b95b38499
https://doi.org/10.1098/rsif.2016.1039
https://doi.org/10.1098/rsif.2016.1039
Autor:
Christine M. Rippinger, Seneca L. Bessling, Thomas J. Smith, Chenchen Yu, Susan K. Wu, Rebecca Zhang, Nicholas S. Giacobbi, Andrew B. Feldman, Christiane E. Wobus, Chunsheng Xia, Jody B. G. Proescher, Audrey Fischer, Ming Li, Jeffrey S. Lin, James M. Pipas, Monica Gamez, Abimbola O. Kolawole, Joshua T. Wolfe, Thomas Mehoke
Publikováno v:
Journal of virology. 88(8)
New human norovirus strains emerge every 2 to 3 years, partly due to mutations in the viral capsid that allow escape from antibody neutralization and herd immunity. To understand how noroviruses evolve antibody resistance, we investigated the structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38cafc7b7468bd8f59ce084aea09796
https://pubmed.ncbi.nlm.nih.gov/24501415
https://pubmed.ncbi.nlm.nih.gov/24501415
Publikováno v:
Circulation research. 98(2)
Many cells are constantly exposed to fluid mechanical forces generated by flowing blood, and wall shear stresses modulate aspects of their structure and function. However, the mechanisms for mechanotransduction of flow are not well understood. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7925d3d483dda1fe2cf500b01707ed
https://pubmed.ncbi.nlm.nih.gov/16456106
https://pubmed.ncbi.nlm.nih.gov/16456106