Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joshua T. McNamara"'
Publikováno v:
Annual Review of Biophysics. 49:41-67
Mitochondria are essential organelles in eukaryotes. Most mitochondrial proteins are encoded by the nuclear genome and translated in the cytosol. Nuclear-encoded mitochondrial proteins need to be imported, processed, folded, and assembled into their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2de67c9538c61d5d8e1f8bc561bd88
https://doi.org/10.1146/annurev-biophys-121219-081604
https://doi.org/10.1146/annurev-biophys-121219-081604
Autor:
Alexander Chih Chieh Chang, Amy Peterson, Rong Li, Yi Dong, Joshua T. McNamara, Gordon Sun, Xi Zhang, Chan Hyun Na, Linhao Ruan, Jin Zhu
Publikováno v:
Science Advances
Formation of solid-phase protein aggregates in mitochondria is associated with mitochondrial lipid metabolism.
Proteostasis declines with age, characterized by the accumulation of unfolded or damaged proteins. Recent studies suggest that protein
Proteostasis declines with age, characterized by the accumulation of unfolded or damaged proteins. Recent studies suggest that protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29b9710bf0caa4c4ca62e810d4c5cc0
https://doi.org/10.1126/sciadv.abc7288
https://doi.org/10.1126/sciadv.abc7288
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e55c3fe4c3ecfba28cea037cdc9ce
https://doi.org/10.1126/science.aad5944
https://doi.org/10.1126/science.aad5944
Publikováno v:
Annual Review of Biochemistry. 84:895-921
Cellulose is the most abundant biopolymer on Earth, and certain organisms from bacteria to plants and animals synthesize cellulose as an extracellular polymer for various biological functions. Humans have used cellulose for millennia as a material an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972b86284ba4a730eba8f631b2906f3b
https://doi.org/10.1146/annurev-biochem-060614-033930
https://doi.org/10.1146/annurev-biochem-060614-033930
Publikováno v:
Nature structural & molecular biology
The bacterial signaling molecule cyclic-di-GMP stimulates the synthesis of bacterial cellulose, frequently found in biofilms. Bacterial cellulose is synthesized and translocated across the inner membrane by a complex of the cellulose synthase BcsA an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73763c345c4ced4a4906edd2c15acb7c
https://doi.org/10.1038/nsmb.2803
https://doi.org/10.1038/nsmb.2803
Publikováno v:
Journal of Molecular Biology. 418:21-31
Hyaluronan (HA), an extracellular linear polysaccharide of alternating N-acetyl-glucosamine and glucuronic acid residues, is ubiquitously expressed in vertebrates, where it affects a broad spectrum of physiological processes, including cell adhesion,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1608a682ac34c25ac6dbd7e9a6a2b86
https://doi.org/10.1016/j.jmb.2012.01.053
https://doi.org/10.1016/j.jmb.2012.01.053
Autor:
Jamie R. Rich, Jochen Zimmer, Joshua T. McNamara, Hong-Ming Chen, Stephen G. Withers, Jacob L. W. Morgan, Michael Fischer
Publikováno v:
Nature
Many biopolymers, including polysaccharides, must be translocated across at least one membrane to reach their site of biological function. Cellulose is a linear glucose polymer synthesized and secreted by a membrane-integrated cellulose synthase. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda44ee274a27c1ae9726d9f6c310e4b
https://pubmed.ncbi.nlm.nih.gov/26958837
https://pubmed.ncbi.nlm.nih.gov/26958837
Autor:
Tobias Schmelzle, Songping Zhao, John A. Tallarico, Vladimir Capka, Emma Lees, Konstantinos J. Mavrakis, Hui Gao, William R. Sellers, Joshua T. McNamara, E. Robert McDonald, Antoine deWeck, Justin Gu, Elizabeth R. Sprague, Raymond Pagliarini, Jeffrey A. Porter, Eric Billy, Craig Mickanin, David A. Ruddy, Fallon Lin, Gregory R. Hoffman, Michael R. Schlabach, Guizhi Yang, Kavitha Venkatesan, Ken Crawford, Yan Yan-Neale, Nicholas Keen, Hong Yin, David Randal Kipp, Yue Liu, Greg McAllister, Kristen Hurov, Francesco Hofmann, Frank Stegmeier, Rosalie deBeaumont, Young Shin Cho, Samuel B. Ho
Publikováno v:
Cancer Research. 76:LB-017
Metabolic genes are increasingly recognized as targets of somatic genetic alteration in human cancer often leading to profound changes in intracellular metabolite concentrations. 5-Methylthioadenosine Phosphorylase (MTAP) is a key enzyme in the methi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43220da53538a3c82105e5b1a0f5cbba
https://doi.org/10.1158/1538-7445.am2016-lb-017
https://doi.org/10.1158/1538-7445.am2016-lb-017