Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Joshua T. Maxwell"'
Autor:
Nour Makkaoui, Vidhya Prasad, Pritha Bagchi, Tiffany Carmona, Ke Li, Olivia L. Latham, Yuanyuan Zhang, Jingyun Lee, Cristina M. Furdui, Joshua T. Maxwell
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Congenital heart defects can lead to right ventricular (RV) pressure-overload and heart failure. Cell-based therapies, including mesenchymal stromal cells (MSCs) and c-kit positive cells (CPCs) have been studied clinically as opti
Externí odkaz:
https://doaj.org/article/0968490c914c49f9aa71ae1a42d1f63e
Autor:
Xiya Yin, Qingfeng Li, Yan Shu, Hongbing Wang, Biju Thomas, Joshua T. Maxwell, Yuanyuan Zhang
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-20 (2024)
Abstract The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources. Among these, urine-derived induced pluripotent stem cells (u-iPSCs) have
Externí odkaz:
https://doaj.org/article/d82d6bdaabca41698e04444e46759739
Autor:
Parvin Forghani, Aysha Rashid, Lawrence C. Armand, David Wolfson, Rui Liu, Hee Cheol Cho, Joshua T. Maxwell, Hanjoong Jo, Khalid Salaita, Chunhui Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous potential for basic research and translational application. However, these cells structurally and functionally resemble fetal cardiomyocytes, whi
Externí odkaz:
https://doaj.org/article/3296641540fe46919673509caadadabf
Autor:
Dong Li, Lawrence C. Armand, Fangxu Sun, Hyun Hwang, David Wolfson, Antonio Rampoldi, Rui Liu, Parvin Forghani, Xin Hu, Wen-Mei Yu, Cheng-Kui Qu, Dean P. Jones, Ronghu Wu, Hee Cheol Cho, Joshua T. Maxwell, Chunhui Xu
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Background Cardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) due to low metabolic maturation. Methods hiPSC-CM spheres were treated w
Externí odkaz:
https://doaj.org/article/562803dacdbb45ed92a888443f4bfd75
Autor:
Vidhya Prasad, Nour Makkaoui, Rohan Rajan, Alisha Patel, Bipul Mainali, Pritha Bagchi, Rhea Kumar, Julia Rogers, Jake Diamond, Joshua T. Maxwell
Publikováno v:
Physiological Reports, Vol 10, Iss 7, Pp n/a-n/a (2022)
Abstract Nearly 1 in every 100 children born have a congenital heart defect. Many of these defects primarily affect the right heart causing pressure overload of the right ventricle (RV). The RV maintains function by adapting to the increased pressure
Externí odkaz:
https://doaj.org/article/c05909849adf4aa4bcb4b057ecf3e9bb
Autor:
Rui Liu, Dong Li, Fangxu Sun, Antonio Rampoldi, Joshua T. Maxwell, Ronghu Wu, Peter Fischbach, Sharon M. Castellino, Yuhong Du, Haian Fu, Anant Mandawat, Chunhui Xu
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Background Treatment-induced cardiotoxicity is a leading noncancer-related cause of acute and late onset morbidity and mortality in cancer patients on antineoplastic drugs such as melphalan—increasing clinical case reports have documented
Externí odkaz:
https://doaj.org/article/612050d0a1544f4d81b8c159c972a2e1
Autor:
Parvin Forghani, Aysha Rashid, Fangxu Sun, Rui Liu, Dong Li, Megan R. Lee, Hyun Hwang, Joshua T. Maxwell, Anant Mandawat, Ronghu Wu, Khalid Salaita, Chunhui Xu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Background Anticancer therapies have significantly improved patient outcomes; however, cardiac side effects from cancer therapies remain a significant challenge. Cardiotoxicity following treatment with proteasome inhibitors such as carfilzomib is kno
Externí odkaz:
https://doaj.org/article/404f0cd859ca4ac0895158d80525b5f3
Autor:
David Trac, Jessica R. Hoffman, Sruti Bheri, Joshua T. Maxwell, Manu O. Platt, Michael E. Davis
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 11, Pp 1212-1221 (2019)
Abstract Congenital heart disease can lead to severe right ventricular heart failure (RVHF). We have shown that aggregated c‐kit+ progenitor cells (CPCs) can improve RVHF repair, likely due to exosome‐mediated effects. Here, we demonstrate that m
Externí odkaz:
https://doaj.org/article/f5b11caa85804aea85990bcbed1580e9
Autor:
Anita Saraf, Antonio Rampoldi, Myra Chao, Dong Li, Lawrence Armand, Hyun Hwang, Rui Liu, Rajnesh Jha, Haian Fu, Joshua T. Maxwell, Chunhui Xu
Publikováno v:
Stem Cell Research, Vol 52, Iss , Pp 102218- (2021)
Proinflammatory molecule tumor necrosis factor alpha (TNF-α) is predominantly elevated in cytokine storm as well as worsening cardiac function. Here we model the molecular and functional effects of TNF-α in cardiomyocytes (CMs) derived from human i
Externí odkaz:
https://doaj.org/article/e182dfabb9764fb0b398bc35b630a5db
Autor:
Olga Brazhkina, Jeong Hun Park, Hyun-Ji Park, Sruti Bheri, Joshua T. Maxwell, Scott J. Hollister, Michael E. Davis
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 12, p 172 (2021)
Myocardial infarction is one of the largest contributors to cardiovascular disease and reduces the ability of the heart to pump blood. One promising therapeutic approach to address the diminished function is the use of cardiac patches composed of bio
Externí odkaz:
https://doaj.org/article/3942c111c6c64a8f908c20d4926c2781