Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Joshua T. Bartoe"'
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-7 (2019)
Abstract Background Open angle glaucoma is the only type of primary glaucoma reported in Beagles. This case report describes a primary angle-closure glaucoma in a Beagle and its diagnostic and prognostic relevance. Case presentation A 12-year-old, ne
Externí odkaz:
https://doaj.org/article/8f99872814d848cb8dbccd23f73d17eb
Autor:
Freya M. Mowat, Laurence M. Occelli, Joshua T. Bartoe, Kristen J. Gervais, Ashlee R. Bruewer, Janice Querubin, Astra Dinculescu, Sanford L. Boye, William W. Hauswirth, Simon M. Petersen-Jones
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Despite mutations in the rod phosphodiesterase 6-alpha (PDE6A) gene being well-recognized as a cause of human retinitis pigmentosa, no definitive treatments have been developed to treat this blinding disease. We performed a trial of retinal gene augm
Externí odkaz:
https://doaj.org/article/106fda91ab70470db82c75ec58db9364
Autor:
Marina Pavlou, Christian Schön, Laurence M Occelli, Axel Rossi, Nadja Meumann, Ryan F Boyd, Joshua T Bartoe, Jakob Siedlecki, Maximilian J Gerhardt, Sabrina Babutzka, Jacqueline Bogedein, Johanna E Wagner, Siegfried G Priglinger, Martin Biel, Simon M Petersen‐Jones, Hildegard Büning, Stylianos Michalakis
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-19 (2021)
Abstract Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which
Externí odkaz:
https://doaj.org/article/8b6c55ffca62471b9aed7b84bf31bc23
Autor:
Emily L. Meany, Roxanne Andaya, Shijia Tang, Catherine M. Kasse, Reina N. Fuji, Abigail K. Grosskopf, Andrea l. d’Aquino, Joshua T. Bartoe, Ryan Ybarra, Amy Shelton, Zachary Pederson, Chloe Hu, Dennis Leung, Karthik Nagapudi, Savita Ubhayakar, Matthew Wright, Chun-Wan Yen, Eric A. Appel
Vision impairment resulting from chronic eye diseases, such as macular degeneration and glaucoma, severely impacts patients’ quality of life and poses an immense global financial burden. Current standard of care for such diseases includes daily eye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00bc5a4ca8b5780598d7329047fdd92
https://doi.org/10.1101/2022.09.08.507193
https://doi.org/10.1101/2022.09.08.507193
Autor:
Keiko, Miyadera, Evelyn, Santana, Karolina, Roszak, Sommer, Iffrig, Meike, Visel, Simone, Iwabe, Ryan F, Boyd, Joshua T, Bartoe, Yu, Sato, Alexa, Gray, Ana, Ripolles-Garcia, Valérie L, Dufour, Leah C, Byrne, John G, Flannery, William A, Beltran, Gustavo D, Aguirre
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
SignificanceCanine models of inherited retinal diseases have helped advance adeno-associated virus (AAV)-based gene therapies targeting specific cells in the outer retina for treating blinding diseases in patients. However, therapeutic targeting of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70329a0b17a28c1ed0f9989922fd2e49
https://pubmed.ncbi.nlm.nih.gov/35316139
https://pubmed.ncbi.nlm.nih.gov/35316139
Autor:
Joshua T. Bartoe, Ryan F. Boyd, Lisa L. Wei, Henry E. Wiley, Paul A. Sieving, Yong Zeng, Dario Marangoni
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 422-427 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Intravitreal administration for human adeno-associated vector (AAV) delivery is easier and less traumatic to ocular tissues than subretinal injection, but it gives limited retinal transduction. AAV vectors are large (about 4,000 kDa) compared with mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b8c6b8de38060066be86e2628a0a41
http://www.sciencedirect.com/science/article/pii/S232905012030139X
http://www.sciencedirect.com/science/article/pii/S232905012030139X
Autor:
Ana Ripolles Garcia, Gustavo D. Aguirre, Meike Visel, Valerie L. Dufour, Karolina Roszak, Yu Sato, Simone Iwabe, Evelyn Santana, Sommer M Iffrig, Keiko Miyadera, Leah C. Byrne, Ryan F. Boyd, William A. Beltran, Alexa Gray, Joshua T. Bartoe, John G. Flannery
AAV gene therapies aimed at curing inherited retinal diseases to date have typically focused on photoreceptors and retinal pigmented epithelia within the relatively accessible outer retina. However, therapeutic targeting in diseases such as congenita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30b5be97b835abdbf5f639f75328139
https://doi.org/10.1101/2021.10.04.462588
https://doi.org/10.1101/2021.10.04.462588
Autor:
Kenneth E, Pierce, Paul G, Curran, Christopher P, Zelinka, Andy J, Fischer, Simon M, Petersen-Jones, Joshua T, Bartoe
Publikováno v:
Advances in experimental medicine and biology. 1185
This study was designed to assess risk for retinal toxicity associated with administration of high-dose sildenafil citrate to dogs heterozygous for a functionally null mutation in Pde6a over a 4-month period. Three Pde6a +/- dogs were administered 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e697d1304b5e60c98b037a292d10d666
https://pubmed.ncbi.nlm.nih.gov/31884640
https://pubmed.ncbi.nlm.nih.gov/31884640
Publikováno v:
Journal of the American Veterinary Medical Association. 252:324-329
CASE DESCRIPTION An 18-month-old spayed female domestic shorthair cat was evaluated because of conjunctivitis and skin-fold dermatitis secondary to bilateral microphthalmia, corneal dermoids, and ankyloblepharon. CLINICAL FINDINGS Physical examinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96e6c5b064d678855678130aae99f6c
https://doi.org/10.2460/javma.252.3.324
https://doi.org/10.2460/javma.252.3.324
Publikováno v:
Veterinary Ophthalmology. 21:104-107
The pupillary light reflex (PLR) is a routinely utilized clinical test to quickly assess integrity of subcortical light perception pathways in patients. While interpretation is simple for ophthalmologists, interestingly discrepancy occurs in annotati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3df7b0dcb6f5b4f09433e9c33eebd5
https://doi.org/10.1111/vop.12469
https://doi.org/10.1111/vop.12469