Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Joshua T Schiffer"'
Autor:
Bryan T Mayer, Allan C deCamp, Yunda Huang, Joshua T Schiffer, Raphael Gottardo, Peter B Gilbert, Daniel B Reeves
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010003 (2022)
Broadly neutralizing antibodies (bNAbs) are promising agents to prevent HIV infection and achieve HIV remission without antiretroviral therapy (ART). As with ART, bNAb combinations are likely needed to cover HIV's extensive diversity. Not all bNAbs a
Externí odkaz:
https://doaj.org/article/b20d108e19284c90906534360439205e
Autor:
Catherine M Byrne, Christine Johnston, Jackson Orem, Fred Okuku, Meei-Li Huang, Habibur Rahman, Anna Wald, Lawrence Corey, Joshua T Schiffer, Corey Casper, Daniel Coombs, Soren Gantt
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009072 (2021)
Epstein-Barr virus (EBV) is transmitted by saliva and is a major cause of cancer, particularly in people living with HIV/AIDS. Here, we describe the frequency and quantity of EBV detection in the saliva of Ugandan adults with and without HIV-1 infect
Externí odkaz:
https://doaj.org/article/d95bea36db6c44b19e604003f8286737
Publikováno v:
eLife, Vol 10 (2021)
SARS-CoV-2 is difficult to contain because many transmissions occur during pre-symptomatic infection. Unlike influenza, most SARS-CoV-2-infected people do not transmit while a small percentage infect large numbers of people. We designed mathematical
Externí odkaz:
https://doaj.org/article/008fe4290c394c67af594a260723aec4
Autor:
Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A York, Daniel L Cameron, Frederick M Hecht, Jeffrey N Martin, Steven A Yukl, Simon Mallal, Paul U Cameron, Steven G Deeks, Joshua T Schiffer, Sharon R Lewin, Marc K Hellerstein, Joseph M McCune, Peter W Hunt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009214 (2021)
The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals,
Externí odkaz:
https://doaj.org/article/1c92de8d5c364b769ed3f828c4efac4a
Autor:
E Fabian Cardozo-Ojeda, Elizabeth R Duke, Christopher W Peterson, Daniel B Reeves, Bryan T Mayer, Hans-Peter Kiem, Joshua T Schiffer
Publikováno v:
eLife, Vol 10 (2021)
Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To projec
Externí odkaz:
https://doaj.org/article/e4fa43b65ac8466fba011375655a9c96
Autor:
Daniel B Reeves, Yunda Huang, Elizabeth R Duke, Bryan T Mayer, E Fabian Cardozo-Ojeda, Florencia A Boshier, David A Swan, Morgane Rolland, Merlin L Robb, John R Mascola, Myron S Cohen, Lawrence Corey, Peter B Gilbert, Joshua T Schiffer
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007626 (2020)
The ongoing Antibody Mediated Prevention (AMP) trials will uncover whether passive infusion of the broadly neutralizing antibody (bNAb) VRC01 can protect against HIV acquisition. Previous statistical simulations indicate these trials may be partially
Externí odkaz:
https://doaj.org/article/b57609ab3ca948799af4d9654506360b
Autor:
Mark D Pankau, Daniel B Reeves, Elias Harkins, Keshet Ronen, Walter Jaoko, Kishor Mandaliya, Susan M Graham, R Scott McClelland, Frederick A Matsen Iv, Joshua T Schiffer, Julie Overbaugh, Dara A Lehman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008286 (2020)
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure. Understanding reservoir seeding dynamics will help identify the best t
Externí odkaz:
https://doaj.org/article/d6a1442f09df4c5197fd3163cf50e6ac
Autor:
Shadisadat Esmaeili, Katherine Owens, Jessica Wagoner, Stephen J. Polyak, Judith M. White, Joshua T. Schiffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In a pivotal trial (EPIC-HR), a 5-day course of oral ritonavir-boosted nirmatrelvir, given early during symptomatic SARS-CoV-2 infection (within three days of symptoms onset), decreased hospitalization and death by 89.1% and nasal viral load
Externí odkaz:
https://doaj.org/article/a3c14c64f2be4649b856e144e4a66648
Autor:
Joshua T Schiffer, David A Swan, Amalia Magaret, Timothy W Schacker, Anna Wald, Lawrence Corey
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0155124 (2016)
A signature feature of HIV infection is poor control of herpes virus infections, which reactivate from latency and cause opportunistic infections. While the general mechanism underlying this observation is deficient CD4+T-cell function, it is unknown
Externí odkaz:
https://doaj.org/article/f7c9e4a2c24142af8b60ecbb52bae831
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 11, p e1003922 (2014)
Herpes simplex virus-2 (HSV-2) is a chronic reactivating infection that leads to recurrent shedding episodes in the genital tract. A minority of episodes are prolonged, and associated with development of painful ulcers. However, currently, available
Externí odkaz:
https://doaj.org/article/3e8568ca3a3b448392bae566d10e3ada