Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Joshua T Mendell"'
Autor:
Mahmoud M Elguindy, Florian Kopp, Mohammad Goodarzi, Frederick Rehfeld, Anu Thomas, Tsung-Cheng Chang, Joshua T Mendell
Publikováno v:
eLife, Vol 8 (2019)
NORAD is a conserved long noncoding RNA (lncRNA) that is required for genome stability in mammals. NORAD acts as a negative regulator of PUMILIO (PUM) proteins in the cytoplasm, and we previously showed that loss of NORAD or PUM hyperactivity results
Externí odkaz:
https://doaj.org/article/adce0dab80ba4cf8a773514a0a1e7633
Autor:
Florian Kopp, Mahmoud M Elguindy, Mehmet E Yalvac, He Zhang, Beibei Chen, Frank A Gillett, Sungyul Lee, Sushama Sivakumar, Hongtao Yu, Yang Xie, Prashant Mishra, Zarife Sahenk, Joshua T Mendell
Publikováno v:
eLife, Vol 8 (2019)
Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in
Externí odkaz:
https://doaj.org/article/11ac600402c64f12aeffc40cfa19a3d5
Autor:
Linwei Wu, Liem H Nguyen, Kejin Zhou, T Yvanka de Soysa, Lin Li, Jason B Miller, Jianmin Tian, Joseph Locker, Shuyuan Zhang, Gen Shinoda, Marc T Seligson, Lauren R Zeitels, Asha Acharya, Sam C Wang, Joshua T Mendell, Xiaoshun He, Jinsuke Nishino, Sean J Morrison, Daniel J Siegwart, George Q Daley, Ng Shyh-Chang, Hao Zhu
Publikováno v:
eLife, Vol 4 (2015)
The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive roles at the expense of regeneration. Too littl
Externí odkaz:
https://doaj.org/article/59dfff35532043c7a4356bb1fec531e8
Autor:
Chang-Ching Lin, Tsung-Cheng Chang, Yunguan Wang, Lei Guo, Yunpeng Gao, Emmanuel Bikorimana, Andrew Lemoff, Yisheng V. Fang, He Zhang, Yanfeng Zhang, Dan Ye, Isabel Soria-Bretones, Alberto Servetto, Kyung-min Lee, Xuemei Luo, Joseph J. Otto, Hiroaki Akamatsu, Fabiana Napolitano, Ram Mani, David W. Cescon, Lin Xu, Yang Xie, Joshua T. Mendell, Ariella B. Hanker, Carlos L. Arteaga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss-of-function alterations conf
Externí odkaz:
https://doaj.org/article/e4a5c7d11ac44ac3ba09402a88d94d20
Autor:
Matthew K Knabel, Kalyani Ramachandran, Sunil Karhadkar, Hun-Way Hwang, Tyler J Creamer, Raghu R Chivukula, Farooq Sheikh, K Reed Clark, Michael Torbenson, Robert A Montgomery, Andrew M Cameron, Joshua T Mendell, Daniel S Warren
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124411 (2015)
Fibrosis refers to the accumulation of excess extracellular matrix (ECM) components and represents a key feature of many chronic inflammatory diseases. Unfortunately, no currently available treatments specifically target this important pathogenic mec
Externí odkaz:
https://doaj.org/article/bf6c1ba14f9d47e3a0e601227e9b4504
Autor:
Lauren R Zeitels, Joshua T Mendell
Publikováno v:
eLife, Vol 2 (2013)
The gene miR-17-92 encodes six different microRNAs, with one of these acting as an internal brake that opposes the oncogenic activity of the others in some cancer contexts.
Externí odkaz:
https://doaj.org/article/ac88fde359394152a5d187cdd70ba304
Autor:
M. Carmen Lafita-Navarro, Yi-Heng Hao, Chunhui Jiang, Seoyeon Jang, Tsung-Cheng Chang, Isabella N. Brown, Niranjan Venkateswaran, Elizabeth Maurais, Weronika Stachera, Yanfeng Zhang, Dorothy Mundy, Jungsoo Han, Vanna M. Tran, Marcel Mettlen, Lin Xu, Jeffrey B. Woodruff, Nick V. Grishin, Lisa Kinch, Joshua T. Mendell, Michael Buszczak, Maralice Conacci-Sorrell
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113280- (2023)
Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRN
Externí odkaz:
https://doaj.org/article/c9443ad8099941449a8b52f34efe5875
Autor:
Frederick Rehfeld, Jennifer L. Eitson, Maikke B. Ohlson, Tsung-Cheng Chang, John W. Schoggins, Joshua T. Mendell
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112076- (2023)
Summary: During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo programmed ribosomal frameshifting (PRF) at a conserved structural el
Externí odkaz:
https://doaj.org/article/c5ee75d2bea24b9592eec718af1d304e
Autor:
Anirban Maitra, Joshua T. Mendell, Oliver A. Kent, Raghu Chivukula, Collins Karikari, Nathaniel R. Campbell, Dipankar Pramanik
Supplementary Figure 1 from Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0200824087929a2b8d912fa34176baa1
https://doi.org/10.1158/1535-7163.22496916.v1
https://doi.org/10.1158/1535-7163.22496916.v1
Autor:
Anirban Maitra, Joshua T. Mendell, Oliver A. Kent, Raghu Chivukula, Collins Karikari, Nathaniel R. Campbell, Dipankar Pramanik
Mis-expression of microRNAs (miRNA) is widespread in human cancers, including in pancreatic cancer. Aberrations of miRNA include overexpression of oncogenic miRs (Onco-miRs) or downregulation of so-called tumor suppressor TSG-miRs. Restitution of TSG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf7d8d1d3827b746463ef9f6b56de71
https://doi.org/10.1158/1535-7163.c.6535431
https://doi.org/10.1158/1535-7163.c.6535431