Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joshua T Burgess"'
Autor:
Sugandha Bhatia, Jennifer H Gunter, Joshua T Burgess, Mark N Adams, Kenneth O'Byrne, Erik W Thompson, Pascal HG Duijf
Publikováno v:
Translational Oncology, Vol 37, Iss , Pp 101760- (2023)
Epithelial-mesenchymal plasticity (EMP) is a hallmark of cancer. By enabling cells to shift between different morphological and functional states, EMP promotes invasion, metastasis and therapy resistance. We report that near-diploid non-cancerous hum
Externí odkaz:
https://doaj.org/article/dffc9a60d0e54a2aa2cf2618bde6ad7a
Autor:
Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA
Externí odkaz:
https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
Autor:
Amila Suraweera, Neha S. Gandhi, Sam Beard, Joshua T. Burgess, Laura V. Croft, Emma Bolderson, Ali Naqi, Nicholas W. Ashton, Mark N. Adams, Kienan I. Savage, Shu-Dong Zhang, Kenneth J. O’Byrne, Derek J. Richard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Amila Suraweera et al. use a range of biochemical and in vitro cellular assays to examine the role of the COMMD4 in DNA repair. Their results suggest that COMMD4 interacts with the histone H2A-H2B during repair of double-stranded DNA breaks, thereby
Externí odkaz:
https://doaj.org/article/d6ec5b410c7346699b96af09c2c4016b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for their roles in DNA repair and as targets for cancer therapeutics. Several P
Externí odkaz:
https://doaj.org/article/db829be50e584b89a3fe209587a016bd
Autor:
Emma Bolderson, Joshua T. Burgess, Jun Li, Neha S. Gandhi, Didier Boucher, Laura V. Croft, Samuel Beard, Jennifer J. Plowman, Amila Suraweera, Mark N. Adams, Ali Naqi, Shu-Dong Zhang, David A. Sinclair, Kenneth J. O’Byrne, Derek J. Richard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Mutation of the nuclear envelope protein, barrier-to-autointegration factor 1 (Banf1), has previously been associated with the development of ageing associated diseases in a human progeria syndrome. Here, the authors reveal the functional link betwee
Externí odkaz:
https://doaj.org/article/193e27c4cfec497c9a58e98a20dcfe50
Autor:
Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T. Burgess, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi, Emma Bolderson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Barrier-to-Autointegration Factor 1 (Banf1/BAF) is a critical component of the nuclear envelope and is involved in the maintenance of chromatin structure and genome stability. Banf1 is a small DNA binding protein that is conserved amongst multicellul
Externí odkaz:
https://doaj.org/article/b1de3dd79957471790866e59707c6fb6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response. PARP1 possesses Poly (ADP-ribose) activity and when activated by DNA
Externí odkaz:
https://doaj.org/article/1aaa2df2c5db4cc3a18ff3502771c276
Autor:
Joshua T. Burgess, Maddison Rose, Didier Boucher, Jennifer Plowman, Christopher Molloy, Mark Fisher, Connor O'Leary, Derek J. Richard, Kenneth J. O'Byrne, Emma Bolderson
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Despite advances in our understanding of the molecular biology of the disease and improved therapeutics, lung cancer remains the most common cause of cancer-related deaths worldwide. Therefore, an unmet need remains for improved treatments, especiall
Externí odkaz:
https://doaj.org/article/92db7189f83a48198b2829a600fa63f3
Publikováno v:
Cancer metastasis reviews. 41(4)
Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths. Therefore, there remains an unmet need for the development of cancer therapies to improve patient qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf81e97ab02f8f7650e3f800187fb43
https://pubmed.ncbi.nlm.nih.gov/36205821
https://pubmed.ncbi.nlm.nih.gov/36205821
Autor:
Ali Naqi, Laura V. Croft, Joshua T. Burgess, Derek J. Richard, Didier Boucher, Sam Beard, Amila Suraweera, Mark N. Adams, J. Plowman, Jun Li, Shu-Dong Zhang, David A. Sinclair, Kenneth J. O'Byrne, Neha S. Gandhi, Emma Bolderson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The DNA repair capacity of human cells declines with age, in a process that is not clearly understood. Mutation of the nuclear envelope protein barrier-to-autointegration factor 1 (Banf1) has previously been shown to cause a human progeroid disorder,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a271a35de2c5468385cd5b766ff02acd
http://link.springer.com/article/10.1038/s41467-019-13167-5
http://link.springer.com/article/10.1038/s41467-019-13167-5