Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Joshua T Bartoe"'
Autor:
Marina Pavlou, Christian Schön, Laurence M Occelli, Axel Rossi, Nadja Meumann, Ryan F Boyd, Joshua T Bartoe, Jakob Siedlecki, Maximilian J Gerhardt, Sabrina Babutzka, Jacqueline Bogedein, Johanna E Wagner, Siegfried G Priglinger, Martin Biel, Simon M Petersen‐Jones, Hildegard Büning, Stylianos Michalakis
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality. Therapeutically impactful targeting of photoreceptors still relies on subretinal vector delivery, which
Externí odkaz:
https://doaj.org/article/8b6c55ffca62471b9aed7b84bf31bc23
Autor:
Dario Marangoni, Ronald A Bush, Yong Zeng, Lisa L Wei, Lucia Ziccardi, Camasamudram Vijayasarathy, Joshua T Bartoe, Kiran Palyada, Maria Santos, Suja Hiriyanna, Zhijian Wu, Peter Colosi, Paul A Sieving
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and is one of the most common causes of macular degeneration in young men. Our therapeutic approach for XLRS is based on the a
Externí odkaz:
https://doaj.org/article/d12423b92da7482e94dd5d7f9b61fe78
Autor:
Paige A Winkler, Kara R Gornik, David T Ramsey, Richard R Dubielzig, Patrick J Venta, Simon M Petersen-Jones, Joshua T Bartoe
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92127 (2014)
The first white Doberman pinscher (WDP) dog was registered by the American Kennel Club in 1976. The novelty of the white coat color resulted in extensive line breeding of this dog and her offspring. The WDP phenotype closely resembles human oculocuta
Externí odkaz:
https://doaj.org/article/2eaee9e3f59b4521bf86e7af3d8199b8
Autor:
Ashlee R Bruewer, Freya M Mowat, Joshua T Bartoe, Sanford L Boye, William W Hauswirth, Simon M Petersen-Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60218 (2013)
Dog models with spontaneously occurring mutations in retinal dystrophy genes are an invaluable resource for preclinical development of retinal gene therapy. Adeno-associated virus (AAV) vectors have been most successful; to target the outer retina an
Externí odkaz:
https://doaj.org/article/e2871352d24e4e2a8f6017846a239d63
Autor:
Paige A Winkler, Kari J Ekenstedt, Laurence M Occelli, Anton V Frattaroli, Joshua T Bartoe, Patrick J Venta, Simon M Petersen-Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72229 (2013)
Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition. We investigated PRA in the Papill
Externí odkaz:
https://doaj.org/article/c611f5ef6f23454a8b800175b8a7f40b
Autor:
Emily L. Meany, Roxanne Andaya, Shijia Tang, Catherine M. Kasse, Reina N. Fuji, Abigail K. Grosskopf, Andrea l. d’Aquino, Joshua T. Bartoe, Ryan Ybarra, Amy Shelton, Zachary Pederson, Chloe Hu, Dennis Leung, Karthik Nagapudi, Savita Ubhayakar, Matthew Wright, Chun-Wan Yen, Eric A. Appel
Vision impairment resulting from chronic eye diseases, such as macular degeneration and glaucoma, severely impacts patients’ quality of life and poses an immense global financial burden. Current standard of care for such diseases includes daily eye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b00bc5a4ca8b5780598d7329047fdd92
https://doi.org/10.1101/2022.09.08.507193
https://doi.org/10.1101/2022.09.08.507193
Autor:
Keiko, Miyadera, Evelyn, Santana, Karolina, Roszak, Sommer, Iffrig, Meike, Visel, Simone, Iwabe, Ryan F, Boyd, Joshua T, Bartoe, Yu, Sato, Alexa, Gray, Ana, Ripolles-Garcia, Valérie L, Dufour, Leah C, Byrne, John G, Flannery, William A, Beltran, Gustavo D, Aguirre
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
SignificanceCanine models of inherited retinal diseases have helped advance adeno-associated virus (AAV)-based gene therapies targeting specific cells in the outer retina for treating blinding diseases in patients. However, therapeutic targeting of d
Autor:
Joshua T. Bartoe, Ryan F. Boyd, Lisa L. Wei, Henry E. Wiley, Paul A. Sieving, Yong Zeng, Dario Marangoni
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 422-427 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Intravitreal administration for human adeno-associated vector (AAV) delivery is easier and less traumatic to ocular tissues than subretinal injection, but it gives limited retinal transduction. AAV vectors are large (about 4,000 kDa) compared with mo
Autor:
Ana Ripolles Garcia, Gustavo D. Aguirre, Meike Visel, Valerie L. Dufour, Karolina Roszak, Yu Sato, Simone Iwabe, Evelyn Santana, Sommer M Iffrig, Keiko Miyadera, Leah C. Byrne, Ryan F. Boyd, William A. Beltran, Alexa Gray, Joshua T. Bartoe, John G. Flannery
AAV gene therapies aimed at curing inherited retinal diseases to date have typically focused on photoreceptors and retinal pigmented epithelia within the relatively accessible outer retina. However, therapeutic targeting in diseases such as congenita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30b5be97b835abdbf5f639f75328139
https://doi.org/10.1101/2021.10.04.462588
https://doi.org/10.1101/2021.10.04.462588
Autor:
Kenneth E, Pierce, Paul G, Curran, Christopher P, Zelinka, Andy J, Fischer, Simon M, Petersen-Jones, Joshua T, Bartoe
Publikováno v:
Advances in experimental medicine and biology. 1185
This study was designed to assess risk for retinal toxicity associated with administration of high-dose sildenafil citrate to dogs heterozygous for a functionally null mutation in Pde6a over a 4-month period. Three Pde6a +/- dogs were administered 14