Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Joshua T, Butcher"'
Publikováno v:
Experimental Gerontology, Vol 181, Iss , Pp 112268- (2023)
In-situ vaccination (ISV) utilizing nanoparticles (NPs) and therapeutic devices like focused ultrasound (FUS) can trigger immune-mediated killing of both treated and untreated cancer cells. However, the impact of confounding factors such as aging and
Externí odkaz:
https://doaj.org/article/0e8a63d70c43460f94c506cb5b451463
Publikováno v:
Biology, Vol 13, Iss 5, p 291 (2024)
The last few decades have brought contraception to the forefront of research, with great strides made in effectively targeting and optimizing the physiology, pharmacology, and delivery processes that prevent pregnancy. However, these advances still p
Externí odkaz:
https://doaj.org/article/e72a1b92d79647659c3e0f399988af8a
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Caleb A. Padgett, Joshua T. Butcher, Steven B. Haigh, Andrew C. Speese, Zachary L. Corley, Cody L. Rosewater, Hunter G. Sellers, Sebastian Larion, James D. Mintz, David J. R. Fulton, David W. Stepp
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Obese individuals are at significantly elevated risk of developing cardiovascular disease (CVD). Additionally, obesity has been associated with disrupted circadian rhythm, manifesting in abnormal sleeping and feeding patterns. To date, the mechanisms
Externí odkaz:
https://doaj.org/article/5763db3859c64c93ace487613e1abb87
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/9b94dfd3c3574240960d80d7073959bb
Autor:
Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G387-G400
Nonalcoholic fatty liver disease (NAFLD) is associated with disruption of homeostatic lipid metabolism, but underlying processes are poorly understood. One possible mechanism is impairment in hepatic circadian rhythm, which regulates key lipogenic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f864cdbd73d82f679a7e99d50bbaf615
https://doi.org/10.1152/ajpgi.00130.2022
https://doi.org/10.1152/ajpgi.00130.2022
Autor:
Brayden D. Halvorson, Nithin J. Menon, Daniel Goldman, Stephanie J. Frisbee, Adam G. Goodwill, Joshua T. Butcher, Phoebe A. Stapleton, Steven D. Brooks, Alexandre C. d’Audiffret, Robert W. Wiseman, Julian H. Lombard, Robert W. Brock, I. Mark Olfert, Paul D. Chantler, Jefferson C. Frisbee
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H475-H489
The study of peripheral vasculopathy with chronic metabolic disease is challenged by divergent contributions from spatial (the level of resolution or specific tissue being studied) and temporal origins (evolution of the developing impairments in time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf289216649d0ddc8dbcc88b3deed2f
https://doi.org/10.1152/ajpheart.00264.2022
https://doi.org/10.1152/ajpheart.00264.2022
Publikováno v:
Aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb6850d75222a5097769c62714aac7e
https://doi.org/10.18632/aging.204750
https://doi.org/10.18632/aging.204750
Autor:
Emily Nunan, Carson L. Wright, Oluwayemisi A. Semola, Madhan Subramanian, Priya Balasubramanian, Pamela C. Lovern, Ibra S. Fancher, Joshua T. Butcher
Publikováno v:
GeroScience. 44:1393-1405
Obesity and aging have both seen dramatic increases in prevalence throughout society. This review seeks to highlight common pathologies that present with obesity, along with the underlying risk factors, that have remarkable similarity to what is obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e8be88112fbca792e8f1bae10d3085
https://doi.org/10.1007/s11357-022-00567-7
https://doi.org/10.1007/s11357-022-00567-7
Autor:
Joshua T. Butcher, James D. Mintz, Sebastian Larion, Shuiqing Qiu, Ling Ruan, David J. Fulton, David W. Stepp
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 16 (2018)
Background Obesity compromises cardiometabolic function and is associated with hypertension and chronic kidney disease. Exercise ameliorates these conditions, even without weight loss. Although the mechanisms of exercise's benefits remain unclear, au
Externí odkaz:
https://doaj.org/article/529139d7ac6748dab0f33a33c3d97521