Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joshua Steinberg"'
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a
Externí odkaz:
https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrec
Externí odkaz:
https://doaj.org/article/920c5aa0d55044bb8e7799f3d44a9730
Autor:
Jack Chovanec, Ilker Tunc, Jason Hughes, Joseph Halstead, Allyson Mateja, Yihui Liu, Michael P. O’Connell, Jiwon Kim, Young Hwan Park, Qinlu Wang, Quang Le, Mehdi Pirooznia, Neil N. Trivedi, Yun Bai, Yuzhi Yin, Amy P. Hsu, Joshua McElwee, Sheryce Lassiter, Celeste Nelson, Judy Bandoh, Thomas DiMaggio, Julij Šelb, Matija Rijavec, Melody C. Carter, Hirsh D. Komarow, Vito Sabato, Joshua Steinberg, Kurt M. Hafer, Elizabeth Feuille, Christopher S. Hourigan, Justin Lack, Paneez Khoury, Irina Maric, Roberta Zanotti, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Sarah C. Glover, Didier G. Ebo, Peter Korošec, George H. Caughey, Erica H. Brittain, Ben Busby, Dean D. Metcalfe, Jonathan J. Lyons
Publikováno v:
Blood Advances. 7:1796-1810
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum tryptase (BST) levels >20 ng/mL are a minor criterion for diagnosis. Although clonal myeloid neoplasms
Autor:
Ashwin N Ananthakrishnan, Gilaad G Kaplan, Charles N Bernstein, Kristin E Burke, Paul J Lochhead, Alexa N Sasson, Manasi Agrawal, Jimmy Ho Tuan Tiong, Joshua Steinberg, Wolfgang Kruis, Flavio Steinwurz, Vineet Ahuja, Siew C Ng, David T Rubin, Jean-Frederic Colombel, Richard Gearry, M Abreu, V Ahuja, M Allez, A Ananthakrishnan, W Bemelman, C Bernstein, J Braun, Y Chowers, J-F Colombel, S Danese, G D'Haens, A D'Hoore, A Dignass, I Dotan, M Dubinsky, A Ekbom, P Fleshner, C Gasche, MA Gassull, R Gearry, S Ghosh, P Gibson, A Griffiths, J Halfvarson, S Hanauer, N Harpaz, A Hart, T Hibi, M Kamm, G Kaplan, A Kaser, B Korelitz, P Kotze, I Koutroubakis, W Kruis, P Lakatos, J Lewis, J Lindsay, E Loftus, E Louis, M Lukas, F Magro, U Mahadevan, G Mantzaris, J-Y Mary, D McGovern, B Moum, P Munkholm, M Neurath, S Ng, C O'Morain, T Oresland, R Panaccione, J Panes, Y Panis, J Pemberton, L Peyrin-Biroulet, C Prantera, D Rachmilewitz, Z Ran, W Reinisch, F Remzi, J Rhodes, R Riddell, G Rogler, D Rubin, D Sachar, W Sandborn, B Sands, B Sartor, J Schoelmerich, S Schreiber, C Siegel, B Siegmund, M Silverberg, J Söderholm, A Sood, A Spinelli, E Stange, F Steinwurz, S Targan, S Travis, D Turner, C Tysk, M Vatn, S Vermeire, M Watanabe, T Yamamoto, J Yamamoto-Furusho
Publikováno v:
Ananthakrishnan, A N, Kaplan, G G, Bernstein, C N, Burke, K E, Lochhead, P J, Sasson, A N, Agrawal, M, Tiong, J H T, Steinberg, J, Kruis, W, Steinwurz, F, Ahuja, V, Ng, S C, Rubin, D T, Colombel, J-F, Gearry, R & International Organization for Study of Inflammatory Bowel Diseases 2022, ' Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases : an International Organization for Study of Inflammatory Bowel Diseases consensus ', The Lancet Gastroenterology & Hepatology, vol. 7, no. 7, pp. 666-678 . https://doi.org/10.1016/S2468-1253(22)00021-8
Environmental and lifestyle factors play an important role in the natural history of Crohn's disease and ulcerative colitis. A group of international experts from the International Organization for the Study of Inflammatory Bowel Diseases voted on a
Autor:
Jack Chovanec, Ilker Tunc, Jason Hughes, Joseph Halstead, Allyson Mateja, Yihui Liu, Michael P. O’Connell, Jiwon Kim, Young Hwan Park, Qinlu Wang, Quang Le, Mehdi Pirooznia, Neil N. Trivedi, Yun Bai, Yuzhi Yin, Amy P. Hsu, Josh McElwee, Sheryce Lassiter, Celeste Nelson, Judy Bandoh, Thomas DiMaggio, Julij Šelb, Matija Rijavec, Melody C. Carter, Hirsh D. Komarow, Vito Sabato, Joshua Steinberg, Kurt M. Hafer, Elizabeth Feuille, Christopher S. Hourigan, Justin Lack, Paneez Khoury, Irina Maric, Roberta Zanotti, Patrizia Bonadonna, Lawrence B. Schwartz, Joshua D. Milner, Sarah C. Glover, Didier G. Ebo, Peter Korošec, George H. Caughey, Erica H. Brittain., Ben Busby, Dean D. Metcalfe, Jonathan J. Lyons
Publikováno v:
Blood advances
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where baseline (BST) levels >20 ng/mL are a minor criterion for diagnosis. Whereas clonal myeloid neoplasms are rare, th
While some mental disorders are inherently characterized by a disconnect from reality, sufferers of most disorders experience varying degrees of clinical insight—the degree to which someone with a mental illness understands that they are afflicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3857b9043258c901da9938b998b9ccce
https://doi.org/10.31234/osf.io/kqs26
https://doi.org/10.31234/osf.io/kqs26
Autor:
Joshua, Steinberg, Sarah E, Lynch
Publikováno v:
American family physician. 103(10)
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The innate and adaptive immune response are regulated by biological clocks, and circulating lymphocytes are lowest at sunrise. Accordingly, severity of disease in mouse models is highly dependent on the time of day of viral infection. Here, we explor
The COVID-19 outbreak has simultaneously increased the need for mental health services and decreased their availability. Brief online self-help interventions that can be completed in a single session could be especially helpful in improving access to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75614b5dc5ff6e3f4f1a8f536f2ec6be
https://doi.org/10.31234/osf.io/x9ch8
https://doi.org/10.31234/osf.io/x9ch8
Autor:
J. Fraser Glickman, Dinshaw J. Patel, Andrew John Jennings, Vitaly Kuryavyi, Aida Jumpei, Pu Gao, Mayako Michino, Wei Xie, Carolina Adura, Takanobu Kuroita, Lavoisier Ramos-Espiritu, Peter T. Meinke, Michael Miller, Toshihiro Imaeda, L. Lama, Kamei Taku, Thomas Tuschl, Tasos Gogakos, Hashizume Shogo, Rei Okamoto, Andrew Stamford, Asano Yasutomi, Joshua Steinberg, Daisuke Tomita
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the en