Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joshua Salafsky"'
Autor:
Yoshiji Hantani, Kiyosei Iio, Rie Hantani, Kayo Umetani, Toshihiro Sato, Tracy Young, Katelyn Connell, Sam Kintz, Joshua Salafsky
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1412-1423 (2018)
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://doaj.org/article/8d0437040b1b4dbdb797c18f711baa16
Autor:
Joyce J. W. Wong, Tracy A. Young, Jiayan Zhang, Shiheng Liu, George P. Leser, Elizabeth A. Komives, Robert A. Lamb, Z. Hong Zhou, Joshua Salafsky, Theodore S. Jardetzky
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conforma
Externí odkaz:
https://doaj.org/article/6bf2cd0a2e484c86a8eb86d2ea0a7ae4
Autor:
Bin Ma, Doug Marcotte, Murugan Paramasivam, Klaus Michelsen, Ti Wang, Andrea Bertolotti-Ciarlet, John Howard Jones, Ben Moree, Margaret Butko, Joshua Salafsky, Xin Sun, Timothy McKee, Laura F Silvian
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165983 (2016)
MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for
Externí odkaz:
https://doaj.org/article/67003a59dd434add954b7cdabddde7a6
Autor:
Marek Kovar, Vijay S. Pande, Jamie B. Spangler, Christina S. Savvides, Stephanie L. Silveria, K. Christopher Garcia, Ariana Peck, Joshua Salafsky, Eleonora Trotta, Jakub Tomala, Jeffrey A. Bluestone, Tracy A. Young, Petra Votavova
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 201, iss 7
Spangler, JB; Trotta, E; Tomala, J; Peck, A; Young, TA; Savvides, CS; et al.(2018). Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. JOURNAL OF IMMUNOLOGY, 201(7), 2094-2106. doi: 10.4049/jimmunol.1800578. UCSF: Retrieved from: http://www.escholarship.org/uc/item/30160235
Spangler, JB; Trotta, E; Tomala, J; Peck, A; Young, TA; Savvides, CS; et al.(2018). Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. JOURNAL OF IMMUNOLOGY, 201(7), 2094-2106. doi: 10.4049/jimmunol.1800578. UCSF: Retrieved from: http://www.escholarship.org/uc/item/30160235
IL-2 has been used to treat diseases ranging from cancer to autoimmune disorders, but its concurrent immunostimulatory and immunosuppressive effects hinder efficacy. IL-2 orchestrates immune cell function through activation of a high-affinity heterot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4425564034c8430da2fb8bf359a5abd
https://doi.org/10.4049/jimmunol.1800578
https://doi.org/10.4049/jimmunol.1800578
Autor:
Tracy A. Young, Toshihiro Sato, Sam Kintz, Kayo Umetani, Kiyosei Iio, Rie Hantani, Joshua Salafsky, Yoshiji Hantani, Katelyn Connell
Publikováno v:
FEBS Open Bio
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635a31bde6e39756a249e1ddbc85cf7
https://doi.org/10.1002/2211-5463.12489
https://doi.org/10.1002/2211-5463.12489
Autor:
Sandra Eltschkner, Weixuan Yu, Jonathan Merino, Caroline Kisker, James J. Truglio, Eleanor K. H. Allen, Ben Moree, Neil Thivalapill, Shabnam Davoodi, Lauren A. Spagnuolo, Peter J. Tonge, Joshua Salafsky, Richard A. Slayden, Fereidoon Daryaee, Annica Pschibul, Susan E. Knudson
Publikováno v:
Journal of the American Chemical Society. 139:3417-3429
A critical goal of lead compound selection and optimization is to maximize target engagement whilst minimizing off-target binding. Since target engagement is a function of both the thermodynamics and kinetics of drug-target interactions, it follows t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeb1c371c30e265b18e7730ec471249
https://doi.org/10.1021/jacs.6b11148
https://doi.org/10.1021/jacs.6b11148
Autor:
Bason Clancy, Joshua Salafsky
Publikováno v:
Physical Chemistry Chemical Physics. 19:3722-3728
Second Harmonic Generation (SHG) has emerged as a highly sensitive probe of protein conformation. SHG can also be used to determine the tilt angle of an SHG-active moiety bound to a surface-adsorbed protein through polarization-dependent measurements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e32e4cff05d7b182a76e2994b5366c
https://doi.org/10.1039/c6cp07708k
https://doi.org/10.1039/c6cp07708k
Autor:
Gabriel Mercado, Paul T. Wilder, Joshua Salafsky, Sina Khorsand, Alexander D. MacKerell, Kristen M. Varney, Que N. Van, Andrew G. Stephen, Frank McCormick, Ben Moree, Wenbo Yu, David J. Weber, Patrick Alexander, Elizabeth Donohue
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 35
Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of biological ligands and small molecules. This study describes the successful implementation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb5bcb2eb61d1a8a2bfc4a0def4d862
https://pubmed.ncbi.nlm.nih.gov/31399543
https://pubmed.ncbi.nlm.nih.gov/31399543
Publikováno v:
Biophysical journal, vol 117, iss 3
Biophysical Journal
Biophysical Journal
Proteins are inherently dynamic, flexible molecules that execute precise conformational changes to perform their functions, but existing techniques to directly measure relevant structural changes in solution at room temperature remain limited. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa76dc4b98e86fe3bab731865faa0d1
https://escholarship.org/uc/item/5n94g22t
https://escholarship.org/uc/item/5n94g22t
Autor:
Juan J. Carrillo, Ben Moree, John Strelow, Mary Geck Do, Joshua Salafsky, Tracy A. Young, Bason Clancy, Tarun Gheyi, Margaret T. Butko
Second-harmonic generation (SHG) has recently emerged as a biophysical tool for conformational sensing of a target biomolecule upon binding to ligands such as small molecules, fragments, proteins, peptides, and oligonucleotides. To date, SHG has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd85075312fdb7e806432d39d62ac79a
https://doi.org/10.1016/bs.mie.2018.09.017
https://doi.org/10.1016/bs.mie.2018.09.017