Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joshua S. Derasp"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The Suzuki-Miyaura coupling is a widely used C-C bond forming reaction. Numerous mechanistic studies have enabled the use of low catalyst loadings and broad functional group tolerance. However, the dominant mode of transmetalation remains co
Externí odkaz:
https://doaj.org/article/e8e7d5570d0e4860ac12ac7a315680e6
Autor:
Madeleine C. Deem, Joshua S. Derasp, Thomas C. Malig, Kea Legard, Curtis P. Berlinguette, Jason E. Hein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The phenomenon of „ring-walking‟, wherein a metal catalyst remains bound to a pi system as it migrates to another coupling site, is supported largely by circumstantial evidence. Here the authors perform an in-depth kinetic study of Buchwald- Hart
Externí odkaz:
https://doaj.org/article/365c13a15c8b45108a75443d68976c01
Autor:
Madeleine C. Deem, Isabelle Cai, Joshua S. Derasp, Paloma L. Prieto, Yusuke Sato, Junliang Liu, Andrew J. Kukor, Jason E. Hein
Publikováno v:
ACS Catalysis. 13:1418-1430
Autor:
André M. Beauchemin, Erica A. Barbera, David D. Brzezinski, Niève R. Séguin, Joshua S. Derasp
Publikováno v:
Organic Letters. 22:7403-7407
Hydroxamic acids are present in a several pharmaceuticals and agrochemicals. Synthetic strategies providing access to hydroxamic acid derivatives remain limited, typically requiring the use of nucl...
Autor:
Joshua S. Derasp, André M. Beauchemin
Publikováno v:
ACS Catalysis. 9:8104-8109
Isocyanates are useful building blocks for the synthesis of amides, although their widespread use has been limited by their high reactivity, which often results in poor functional group tolerance a...
Autor:
Joshua S, Derasp, Erica A, Barbera, Niève R, Séguin, David D, Brzezinski, André M, Beauchemin
Publikováno v:
Organic letters. 22(18)
Hydroxamic acids are present in a several pharmaceuticals and agrochemicals. Synthetic strategies providing access to hydroxamic acid derivatives remain limited, typically requiring the use of nucleophilic hydroxylamine reagents. Herein, a synthesis
Publikováno v:
Synlett. 28:456-460
A cascade synthesis of 1,2,4-triazin-3(2H)-ones is reported from readily accessible α-amino ketones and phenyl carbazate as a masked N-isocyanate precursor. The mild protocol provides a simple route to products with substitution patterns which are d
Publikováno v:
Organic Letters. 18:658-661
Cascade reactions for the synthesis of 1,2,4-triazinones and 5-aminopyridazinones are reported using α-ketocarbazones as N-isocyanate precursors and exploiting the divergent reactivity observed with primary and secondary amines. Triazinones were for
Publikováno v:
ChemInform. 47
Cascade reactions for the synthesis of 1,2,4-triazinones and 5-aminopyridazinones are reported using α-ketocarbazones as N-isocyanate precursors and exploiting the divergent reactivity observed with primary and secondary amines. Triazinones were for
Publikováno v:
ChemInform. 47
The microwave-assisted triethylamine-catalyzed reaction of hydrazone-based N-isocyanate precursors (I) and (IV) with propargylamines (II) leads to imidazolones (III) and (V), respectively.