Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Joshua S. Boger"'
Autor:
Joanne F. Kinneary, Alita A. Davis, Joshua S. Boger, Kathleen M. Rupprecht, Robert K. Baker, Paul J. Hodges
Publikováno v:
Tetrahedron Letters. 39:233-236
The C10C17 fragment of the natural product, FK-506, has been stereoselectively synthesized from L-gulose. Methods for elaboration to the C1C17 fragment and installation of the C9 carbonyl group are described.
Autor:
Bruce E. Witzel, David M. Armistead, Joshua S. Boger, Judith M. Pissano, Robert K. Baker, Kathleen M. Rupprecht, Karst Hoogsteen, Robert A. Frankshun, Paul J. Hodges
Publikováno v:
Tetrahedron Letters. 39:229-232
The C28C32 cyclohexyl group of the natural product, FK-506, was prepared enantioselectively from the iodolactone by replacement of iodide with retention of configuration . The C27C28 trisubstituted olefin was introduced stereoselectively via a
Autor:
Vincent Galullo, Dlna Shlyakhter, Joshua S. Boger, Matthew W. Harding, David M. Armistead, Saunders Jeffrey O, John P. Duffy, Zelle Robert E, Ursula A. Germann, Valerie S Mason
Publikováno v:
Anti-Cancer Drugs. 8:125-140
VX-710 or (S)-N[2-Oxo-2-(3,4,5-trimethoxyphenyl)acetyl]-piperidine-2-carboxylic acid 1,7-bis(3-pyridyl)-4-heptyl ester, a novel non-macrocyclic ligand of the FK506-binding protein FKBP12, was evaluated for its ability to reverse P-glycoprotein-mediat
Autor:
Karst Hoogsteen, James P. Springer, Kathleen M. Rupprecht, Robert B. Nachbar, Joshua S. Boger
Publikováno v:
ChemInform. 23
Autor:
Kathleen M. Rupprecht, B. E. Witzel, Paul J. Hodges, Karst Hoogsteen, David M. Armistead, Joshua S. Boger, Judith M. Pisano, Robert K. Baker, Robert A. Frankshun
Publikováno v:
ChemInform. 29
Autor:
Joshua S. Boger, Kathleen M. Rupprecht, Robert K. Baker, Alita A. Davis, Joanne F. Kinneary, Paul J. Hodges
Publikováno v:
ChemInform. 29
The C10C17 fragment of the natural product, FK-506, has been stereoselectively synthesized from L-gulose. Methods for elaboration to the C1C17 fragment and installation of the C9 carbonyl group are described.
The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic
Autor:
Sumire V. Kobayashi, Dana N. Cianciarulo, Thomas E. Rollins, Robert A. Zambias, Salvatore J. Siciliano, Charles G. Caldwell, Steven S. Bondy, Joung L. Goulet, Joshua S. Boger, Martin S. Springer, Milton L. Hammond, Philippe L. Durette, Joanne F. Kinneary, William K. Hagmann, Thomas J. Lanza, Ihor E. Kopka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1033-1038
The cyclic hexadepsipeptide antibiotic L-156,602 ( 1 ) was found to be an inhibitor of anaphylatoxin C5a binding to its receptor (IC 50 =1.7 μg/mL). This compound also caused nonspecific degranulation of neutrophils, but not through interactions wit
Autor:
James P. Springer, Robert B. Nachbar, Kathleen M. Rupprecht, Joshua S. Boger, Karst Hoogsteen
Publikováno v:
The Journal of Organic Chemistry. 56:6180-6188
Autor:
Mark T. Goulet, Joshua S. Boger
Publikováno v:
Tetrahedron Letters. 31:4845-4848
The degradation of rapamycin, a tricarbonyl containing macrolide similar in structure to the potent immunosuppressant FK-506, is described. Three principal fragments are obtained in this process that should have utility in the semi-synthesis of FK-50
Autor:
Peter L. Barker, Thomas J. Lanza, Milton L. Hammond, Florence Baker, Steven S. Bondy, Charles G. Caldwell, Philippe L. Durette, Arsenio A. Pessolano, Joshua S. Boger
Publikováno v:
Tetrahedron Letters. 31:1237-1240
The total synthesis of the naturally occurring cyclic hexadepsipeptide antibiotic L-156,602 ( 1 ) is described.