Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joshua S. Alford"'
Autor:
Joshua S. Alford, Nadia C. Abascal, Christopher R. Shugrue, Sean M. Colvin, David K. Romney, Scott J. Miller
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 733-739 (2016)
Externí odkaz:
https://doaj.org/article/4f58c1efba964f8caa33a69e9dce521a
Publikováno v:
The Journal of Organic Chemistry. 87:13517-13528
Rhodium-catalyzed enantioselective synthesis of 1-phenoxycyclopropane-1-carbaldehydes by intermolecular cyclopropanation of terminal alkenes followed by imine hydrolysis is described. This methodology utilizes 4-aryloxy-1-sulfonyl-1,2,3-triazoles as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1730da9543d7f24c627751c1617303df
https://doi.org/10.1021/acs.joc.2c00978
https://doi.org/10.1021/acs.joc.2c00978
Autor:
Joshua S. Alford, John W. Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Kenneth W. Duncan, Sean T. Eckley, Jeffrey L. Kutok, Alejandra Raimondi, Thomas V. Riera, Brian Shook, Cuyue Tang, Jennifer Totman, Neil A. Farrow
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1137-1143
SETD2, a lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0923d93af3913acf097ff9afc7c6e1
https://doi.org/10.1021/acsmedchemlett.2c00167
https://doi.org/10.1021/acsmedchemlett.2c00167
Autor:
Thomas V. Riera, Lampe John W, Cuyue Tang, Kat Cosmopoulos, Alejandra Raimondi, Michael John Munchhof, Neil A. Farrow, Kenneth W. Duncan, Dorothy Brach, Vinny Motwani, Darren Martin Harvey, P. Ann Boriak-Sjodin, Sean T. Eckley, Jennifer Totman, Joshua S Alford, Megan Alene Cloonan Foley, Michael J Thomenius
Publikováno v:
ACS Medicinal Chemistry Letters
SET domain-containing protein 2 (SETD2), a histone methyltransferase, has been identified as a target of interest in certain hematological malignancies, including multiple myeloma. This account details the discovery of EPZ-719, a novel and potent SET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c70d3b49c7dd565ec207bc48d880872
https://pubmed.ncbi.nlm.nih.gov/34671445
https://pubmed.ncbi.nlm.nih.gov/34671445
Autor:
Sean M. Colvin, Christopher R. Shugrue, Scott J. Miller, Nadia C. Abascal, David K. Romney, Joshua S. Alford
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 733-739 (2016)
ACS Central Science
ACS Central Science
A remarkable aspect of enzyme evolution is the portability of catalytic mechanisms for fundamentally different chemical reactions. For example, aspartyl proteases, which contain two active site carboxylic acid groups, catalyze the hydrolysis of amide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a297c654eb0f9d3e1614943546e98468
https://doi.org/10.1021/acscentsci.6b00237
https://doi.org/10.1021/acscentsci.6b00237
Autor:
Joshua S. Alford, Huw M. L. Davies, Tetsushi Yoshidomi, Sidney M. Wilkerson-Hill, Robert W. Kubiak, Jeffrey D. Mighion
Publikováno v:
Organic Letters. 18:3118-3121
The enantioselective intermolecular sp(3) C-H functionalization at the allylic and benzylic positions was achieved using rhodium-catalyzed reactions with 4-phenyl-N-(methanesulfonyl)-1,2,3-triazole. The optimum dirhodium tetracarboxylate catalyst for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa2046170b51c7e0d479540b995ea30
https://doi.org/10.1021/acs.orglett.6b01298
https://doi.org/10.1021/acs.orglett.6b01298
Autor:
Tetsushi Yoshidomi, Joshua S. Alford, Robert W. Kubiak, Jeffrey D. Mighion, Sidney M. Wilkerson-Hill, Huw M. L. Davies
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9a065dfbc6064ba025af3e2fa6f3c3
https://doi.org/10.1002/chin.201646063
https://doi.org/10.1002/chin.201646063
Publikováno v:
Journal of Physical Organic Chemistry. 24:1119-1128
Highest occupied molecular orbital–lowest unoccupied molecular orbital (HOMO–LUMO) tuning is an important consideration in the development of organic-based semiconducting materials. A study of the specific effects and overall trends for the HOMO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6187c506538ca809c02ec692863b4b10
https://doi.org/10.1002/poc.1864
https://doi.org/10.1002/poc.1864
Autor:
Huw M. L. Davies, Joshua S. Alford
Publikováno v:
ChemInform. 46
The synthesis of the corresponding pyrrole derivatives is accomplished in a two-component reaction by using triazole (X).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5df663071edd46fd46f372e4fa26ef8b
https://doi.org/10.1002/chin.201507170
https://doi.org/10.1002/chin.201507170
Autor:
Huw M. L. Davies, Joshua S. Alford
Publikováno v:
ChemInform. 45
Review: such as transannulation reactions to generate new heterocycles, cyclopropanation and subsequent ring expansions, ylide formation with subsequent rearrangements, and C—H functionalization; 55 refs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dca83dad9a982416eb3bdee2826b478c
https://doi.org/10.1002/chin.201438231
https://doi.org/10.1002/chin.201438231