Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Joshua S Waxman"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 11, p e1011222 (2024)
Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte (AC) differentiation. However, little is known about the mechanisms directing Nr2f expression in ACs. Here, we identified a conserved enhancer 3' to the nr2f
Externí odkaz:
https://doaj.org/article/90ea3797a6a548718a8eb2c725072d6c
Autor:
Kendall E Martin, Padmapriyadarshini Ravisankar, Manu Beerens, Calum A MacRae, Joshua S Waxman
Publikováno v:
eLife, Vol 12 (2023)
Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains incomplete. Here, we show that sustained expression of the zebrafish transcription factor Nr2f1a
Externí odkaz:
https://doaj.org/article/f836804f17944076be9c284e9dd8ddfc
Publikováno v:
eLife, Vol 11 (2022)
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline from distant lateral positions. Little is known about what controls the precise timing of angioblast migration and their fi
Externí odkaz:
https://doaj.org/article/cb2927aa28a64deaba323e8a39683bbd
Autor:
Ugo Coppola, Joshua S Waxman
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0254282 (2021)
BackgroundNuclear Receptor Subfamily 2 Group F (Nr2f) orphan nuclear hormone transcription factors (TFs) are fundamental regulators of many developmental processes in invertebrates and vertebrates. Despite the importance of these TFs throughout metaz
Externí odkaz:
https://doaj.org/article/f1903d5cfa3e4cdfa7843e573b915aa9
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008165 (2019)
Coordinated transcriptional and epigenetic mechanisms that direct development of the later differentiating second heart field (SHF) progenitors remain largely unknown. Here, we show that a novel zebrafish histone deacetylase 1 (hdac1) mutant allele c
Externí odkaz:
https://doaj.org/article/688799c27926458d924ce31a448c670c
Autor:
Tracy E Dohn, Padmapriyadarshini Ravisankar, Fouley T Tirera, Kendall E Martin, Jacob T Gafranek, Tiffany B Duong, Terri L VanDyke, Melissa Touvron, Lindsey A Barske, J Gage Crump, Joshua S Waxman
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007962 (2019)
Multiple syndromes share congenital heart and craniofacial muscle defects, indicating there is an intimate relationship between the adjacent cardiac and pharyngeal muscle (PM) progenitor fields. However, mechanisms that direct antagonistic lineage de
Externí odkaz:
https://doaj.org/article/240d1ba88b8b4c0cb4b6ef2a5e18629f
Autor:
Ariel B Rydeen, Joshua S Waxman
Publikováno v:
PLoS Biology, Vol 14, Iss 11, p e2000504 (2016)
Although retinoic acid (RA) teratogenicity has been investigated for decades, the mechanisms underlying RA-induced outflow tract (OFT) malformations are not understood. Here, we show zebrafish embryos deficient for Cyp26a1 and Cyp26c1 enzymes, which
Externí odkaz:
https://doaj.org/article/2f0264f911054410b3a77a9d5d960a90
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138588 (2015)
The first step in the conversion of vitamin A into retinoic acid (RA) in embryos requires retinol dehydrogenases (RDHs). Recent studies have demonstrated that RDH10 is a critical core component of the machinery that produces RA in mouse and Xenopus e
Externí odkaz:
https://doaj.org/article/32062403c50f43d0afacd7eb9d0714ee
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003689 (2013)
Normal embryonic development and tissue homeostasis require precise levels of retinoic acid (RA) signaling. Despite the importance of appropriate embryonic RA signaling levels, the mechanisms underlying congenital defects due to perturbations of RA s
Externí odkaz:
https://doaj.org/article/048e5e53669e45ee9de310c045566a29
Autor:
Eliyahu Perl, Padmapriyadarshini Ravisankar, Manu E. Beerens, Lejla Mulahasanovic, Kelly Smallwood, Marion Bermúdez Sasso, Carina Wenzel, Thomas D. Ryan, Matej Komár, Kevin E. Bove, Calum A. MacRae, K. Nicole Weaver, Carlos E. Prada, Joshua S. Waxman
Publikováno v:
HGG Advances, Vol 3, Iss 3, Pp 100115- (2022)
Summary: Requirements for vesicle fusion within the heart remain poorly understood, despite the multitude of processes that necessitate proper intracellular trafficking within cardiomyocytes. Here, we show that Syntaxin 4 (STX4), a target-Soluble N-e
Externí odkaz:
https://doaj.org/article/69a4013e43b2410292ce66f8fe329a35