Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Joshua S Alwood"'
Autor:
Megan M Pendleton, Shannon R Emerzian, Saghi Sadoughi, Alfred Li, Jennifer W Liu, Simon Y Tang, Grace D O'Connell, Jean D Sibonga, Joshua S Alwood, Tony M Keaveny
Publikováno v:
JBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)
ABSTRACT Humans are exposed to ionizing radiation via spaceflight or cancer radiotherapy, and exposure from radiotherapy is known to increase risk of skeletal fractures. Although irradiation can reduce trabecular bone mass, alter trabecular microarch
Externí odkaz:
https://doaj.org/article/58ae334e547645b9a909a70b799bcf1b
Autor:
Eneko Axpe, Doreen Chan, Metadel F Abegaz, Ann-Sofie Schreurs, Joshua S Alwood, Ruth K Globus, Eric A Appel
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226434 (2020)
A round-trip human mission to Mars is anticipated to last roughly three years. Spaceflight conditions are known to cause loss of bone mineral density (BMD) in astronauts, increasing bone fracture risk. There is an urgent need to understand BMD progre
Externí odkaz:
https://doaj.org/article/ff761a2f4b8c412cbabba4d108328d2f
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167391 (2016)
Even with recent scientific advancements, challenges posed by limited resources and capabilities at the time of sample dissection continue to limit the collection of high quality tissues from experiments that can be conducted only infrequently and at
Externí odkaz:
https://doaj.org/article/2bc1fcfd3db14056aad3bd696dcf7a3c
Autor:
Marissa Burke, Kelly Wong, Yuli Talyansky, Siddhita D. Mhatre, Carol Mitchell, Cassandra M. Juran, Makaila Olson, Janani Iyer, Stephanie Puukila, Candice G. T. Tahimic, Lane K. Christenson, Moniece Lowe, Linda Rubinstein, Yasaman Shirazi-Fard, Marianne B. Sowa, Joshua S. Alwood, April E. Ronca, Amber M. Paul
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Exposure to cosmic ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and altered cellular function. In astronauts, longitudinal monitoring of physiological systems and interactions between these sy
Externí odkaz:
https://doaj.org/article/a49ceff1b5d94721b1f2bc6e8f711071
Autor:
Elizabeth A Blaber, Natalya Dvorochkin, Chialing Lee, Joshua S Alwood, Rukhsana Yousuf, Piero Pianetta, Ruth K Globus, Brendan P Burns, Eduardo A C Almeida
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61372 (2013)
Bone is a dynamically remodeled tissue that requires gravity-mediated mechanical stimulation for maintenance of mineral content and structure. Homeostasis in bone occurs through a balance in the activities and signaling of osteoclasts, osteoblasts, a
Externí odkaz:
https://doaj.org/article/b65c567363d34610bbdcd61f24c83131
Autor:
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Publikováno v:
Life, Vol 13, Iss 9, p 1852 (2023)
Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain region
Externí odkaz:
https://doaj.org/article/fae5ebc0ec5a4b04b825de8bc8b7ab7e
Autor:
Stephanie Puukila, Olivia Siu, Linda Rubinstein, Candice G. T. Tahimic, Moniece Lowe, Steffy Tabares Ruiz, Ivan Korostenskij, Maya Semel, Janani Iyer, Siddhita D. Mhatre, Yasaman Shirazi-Fard, Joshua S. Alwood, Amber M. Paul, April E. Ronca
Publikováno v:
Life, Vol 13, Iss 5, p 1214 (2023)
Exposure to space galactic cosmic radiation is a principal consideration for deep space missions. While the effects of space irradiation on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiatio
Externí odkaz:
https://doaj.org/article/783b8f85f80648558e9d9925d3da7f2f
Autor:
Candice G. T. Tahimic, Amber M. Paul, Ann-Sofie Schreurs, Samantha M. Torres, Linda Rubinstein, Sonette Steczina, Moniece Lowe, Sharmila Bhattacharya, Joshua S. Alwood, April E. Ronca, Ruth K. Globus
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, a
Externí odkaz:
https://doaj.org/article/259c5e8237774417acb4f6a047182e50
Autor:
Ruth K. Globus, Moniece Lowe, Linda Rubinstein, Joshua S. Alwood, Stephanie Puukila, Amber M. Paul, Siddhita D. Mhatre, Candice Tahimic, Janani Iyer, Sharmila Bhattacharya, Marianne B. Sowa, April E. Ronca
Publikováno v:
Neuroscience & Biobehavioral Reviews. 132:908-935
As human space exploration advances to establish a permanent presence beyond the Low Earth Orbit (LEO) with NASA’s Artemis mission, researchers are striving to understand and address the health challenges of living and working in the spaceflight en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d4be46e4387516c34da027ea7ba53
https://doi.org/10.1016/j.neubiorev.2021.09.055
https://doi.org/10.1016/j.neubiorev.2021.09.055
Autor:
Akhhilesh Kumar, Joshua S. Alwood, Eric L. Moyer, Samantha Torres, Ruth K. Globus, Candice Tahimic, Ann-Sofie Schreurs, Tiffany Truong
Publikováno v:
American Journal of Physiology-Cell Physiology. 319:C734-C745
Accumulation of oxidative damage from excess reactive oxygen species (ROS) may contribute to skeletal aging and mediate adverse responses to physiological challenges. Wild-type (WT) mice and transgenic mice (male, 16 wk of age) with human catalase ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2030022ffaf083f1e55be0677c3040
https://doi.org/10.1152/ajpcell.00068.2020
https://doi.org/10.1152/ajpcell.00068.2020