Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Joshua S Alwood"'
Autor:
Marissa Burke, Kelly Wong, Yuli Talyansky, Siddhita D. Mhatre, Carol Mitchell, Cassandra M. Juran, Makaila Olson, Janani Iyer, Stephanie Puukila, Candice G. T. Tahimic, Lane K. Christenson, Moniece Lowe, Linda Rubinstein, Yasaman Shirazi-Fard, Marianne B. Sowa, Joshua S. Alwood, April E. Ronca, Amber M. Paul
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Exposure to cosmic ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and altered cellular function. In astronauts, longitudinal monitoring of physiological systems and interactions between these sy
Externí odkaz:
https://doaj.org/article/a49ceff1b5d94721b1f2bc6e8f711071
Autor:
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Publikováno v:
Life, Vol 13, Iss 9, p 1852 (2023)
Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain region
Externí odkaz:
https://doaj.org/article/fae5ebc0ec5a4b04b825de8bc8b7ab7e
Autor:
Stephanie Puukila, Olivia Siu, Linda Rubinstein, Candice G. T. Tahimic, Moniece Lowe, Steffy Tabares Ruiz, Ivan Korostenskij, Maya Semel, Janani Iyer, Siddhita D. Mhatre, Yasaman Shirazi-Fard, Joshua S. Alwood, Amber M. Paul, April E. Ronca
Publikováno v:
Life, Vol 13, Iss 5, p 1214 (2023)
Exposure to space galactic cosmic radiation is a principal consideration for deep space missions. While the effects of space irradiation on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiatio
Externí odkaz:
https://doaj.org/article/783b8f85f80648558e9d9925d3da7f2f
Autor:
Xiaoman Hong, Anamika Ratri, Sungshin Y. Choi, Joseph S. Tash, April E. Ronca, Joshua S. Alwood, Lane K. Christenson
Publikováno v:
npj Microgravity, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Ovarian steroids dramatically impact normal homeostatic and metabolic processes of most tissues within the body, including muscle, bone, neural, immune, cardiovascular, and reproductive systems. Determining the effects of spaceflight on the
Externí odkaz:
https://doaj.org/article/4fdd39a8dc864f128470ff20d63eda80
Autor:
Megan M Pendleton, Shannon R Emerzian, Saghi Sadoughi, Alfred Li, Jennifer W Liu, Simon Y Tang, Grace D O'Connell, Jean D Sibonga, Joshua S Alwood, Tony M Keaveny
Publikováno v:
JBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)
ABSTRACT Humans are exposed to ionizing radiation via spaceflight or cancer radiotherapy, and exposure from radiotherapy is known to increase risk of skeletal fractures. Although irradiation can reduce trabecular bone mass, alter trabecular microarch
Externí odkaz:
https://doaj.org/article/58ae334e547645b9a909a70b799bcf1b
Autor:
Eneko Axpe, Doreen Chan, Metadel F Abegaz, Ann-Sofie Schreurs, Joshua S Alwood, Ruth K Globus, Eric A Appel
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226434 (2020)
A round-trip human mission to Mars is anticipated to last roughly three years. Spaceflight conditions are known to cause loss of bone mineral density (BMD) in astronauts, increasing bone fracture risk. There is an urgent need to understand BMD progre
Externí odkaz:
https://doaj.org/article/ff761a2f4b8c412cbabba4d108328d2f
Autor:
Megan M. Pendleton, Saghi Sadoughi, Alfred Li, Grace D. O'Connell, Joshua S. Alwood, Tony M. Keaveny
Publikováno v:
Bone Reports, Vol 9, Iss , Pp 165-172 (2018)
One potentially important bone quality characteristic is the response of bone to cyclic (repetitive) mechanical loading. In small animals, such as in rats and mice, cyclic loading experiments are particularly challenging to perform in a precise manne
Externí odkaz:
https://doaj.org/article/b66c33c2b7044ff69cb56fc395e72527
Autor:
Joshua S. Alwood, April E. Ronca, Richard C. Mains, Mark J. Shelhamer, Jeffrey D. Smith, Thomas J. Goodwin
Publikováno v:
npj Microgravity, Vol 3, Iss 1, Pp 1-9 (2017)
Abstract NASA’s Space Biology and Human Research Program entities have recently spearheaded communications both internally and externally to coordinate the agency’s translational research efforts. In this paper, we strongly advocate for translati
Externí odkaz:
https://doaj.org/article/a673cc61a34d4ea1bca117ba5e5f2dba
Autor:
Candice G. T. Tahimic, Amber M. Paul, Ann-Sofie Schreurs, Samantha M. Torres, Linda Rubinstein, Sonette Steczina, Moniece Lowe, Sharmila Bhattacharya, Joshua S. Alwood, April E. Ronca, Ruth K. Globus
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, a
Externí odkaz:
https://doaj.org/article/259c5e8237774417acb4f6a047182e50
Autor:
Ruth K. Globus, Moniece Lowe, Linda Rubinstein, Joshua S. Alwood, Stephanie Puukila, Amber M. Paul, Siddhita D. Mhatre, Candice Tahimic, Janani Iyer, Sharmila Bhattacharya, Marianne B. Sowa, April E. Ronca
Publikováno v:
Neuroscience & Biobehavioral Reviews. 132:908-935
As human space exploration advances to establish a permanent presence beyond the Low Earth Orbit (LEO) with NASA’s Artemis mission, researchers are striving to understand and address the health challenges of living and working in the spaceflight en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d4be46e4387516c34da027ea7ba53
https://doi.org/10.1016/j.neubiorev.2021.09.055
https://doi.org/10.1016/j.neubiorev.2021.09.055