Effects of sub-chronic Cd exposure on levels of copper, selenium, zinc, iron and other essential metals in rat renal cortex

Autor: Walter C. Prozialeck, Peter C. Lamar, Joshua R. Edwards

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 740-746 (2016)

Cd (Cd) is a nephrotoxic environmental pollutant that causes generalized proximal tubule dysfunction. Even though the specific mechanisms by which Cd damages the kidney have yet to be fully elucidated, there is evidence to suggest that some of these

Externí odkaz: https://doaj.org/article/bb341086508749b8aa520c951c61df10

Cadmium Nephrotoxicity Is Associated with Altered MicroRNA Expression in the Rat Renal Cortex

Autor: Michael J. Fay, Lauren A. C. Alt, Dominika Ryba, Ribhi Salamah, Ryan Peach, Alexander Papaeliou, Sabina Zawadzka, Andrew Weiss, Nil Patel, Asad Rahman, Zyaria Stubbs-Russell, Peter C. Lamar, Joshua R. Edwards, Walter C. Prozialeck

Publikováno v: Toxics, Vol 6, Iss 1, p 16 (2018)

Cadmium (Cd) is a nephrotoxic environmental pollutant that causes a generalized dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though the effects of Cd on the kidney have been well-characterized, the molecular mech

Externí odkaz: https://doaj.org/article/94d7238cdebf439c8f1bba22c59ddfed

Using FluoZin-3 and fura-2 to monitor acute accumulation of free intracellular Cd2+ in a pancreatic beta cell line

Autor: Kirk E. Dineley, Latha M. Malaiyandi, Harsh Sharthiya, Joshua R. Edwards, Ameir Barakat

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

The understanding of cellular Cd2+accumulation and toxicity is hampered by a lack of fluorescent indicators selective for intracellular free Cd2+([Cd2+]i). In this study, we used depolarized MIN6 mouse pancreatic beta cells as a model for evaluating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c729ec458683c5b0263adb2d88072e
http://europepmc.org/articles/PMC7446769

Evaluation of the Mitragynine Content, Levels of Toxic Metals and the Presence of Microbes in Kratom Products Purchased in the Western Suburbs of Chicago

Autor: Joshua R. Edwards, Charles A. Veltri, Walter C. Prozialeck, Ira M. Sigar, Balbina J. Plotkin, Oliver Grundmann, Peter C. Lamar

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 5512, p 5512 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 15

Kratom (Mitragyna speciosa, Korth) is a tree-like plant that is indigenous to Southeast Asia. Kratom leaf products have been used in traditional folk medicine for their unique combination of stimulant and opioid-like effects. Kratom is being increasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d0e74404e515925fd5a35c7ab1898
https://www.mdpi.com/1660-4601/17/15/5512

A Method for the Evaluation of Site-Specific Nephrotoxic Injury in the Intact Rat Kidney

Autor: Joshua R. Edwards, Walter C. Prozialeck, Aaron VanDreel, Michael Kowal, Peter C. Lamar

Publikováno v: Toxics
Volume 8
Issue 1
Toxics, Vol 8, Iss 1, p 4 (2020)

In a previously published report we detailed an in situ method to quantify cell death in the renal cortex by perfusing the cell membrane impermeable fluorochrome, ethidium homodimer in situ. The objective of the present study was to use this in situ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b31e968357c7e6ced579719df8c00f
https://pubmed.ncbi.nlm.nih.gov/31968633