Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joshua R. Brickner"'
Autor:
Delphine Lemaçon, Jessica Jackson, Annabel Quinet, Joshua R. Brickner, Shan Li, Stephanie Yazinski, Zhongsheng You, Grzegorz Ira, Lee Zou, Nima Mosammaparast, Alessandro Vindigni
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependen
Externí odkaz:
https://doaj.org/article/1e33c6e0d83d4e20804ca0da99f3189b
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Supplementary Table from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032a5df391d5f4fa05c5afc7f2e1db25
https://doi.org/10.1158/2159-8290.22541404.v1
https://doi.org/10.1158/2159-8290.22541404.v1
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7aff3a4b13eb09415758e2513af039
https://doi.org/10.1158/2159-8290.c.6549634.v1
https://doi.org/10.1158/2159-8290.c.6549634.v1
Autor:
Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović
Supplementary Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01500e10207400a070376439f471923d
https://doi.org/10.1158/2159-8290.22541428.v1
https://doi.org/10.1158/2159-8290.22541428.v1
Autor:
Brittany A. Townley, Luke Buerer, Albino Bacolla, Timur Rusanov, Nicolas Schmidt, Sridhar N. Srivatsan, Nathanial E. Clark, Fadhel Mansoori, Reilly A. Sample, Joshua R. Brickner, Drew McDonald, Miaw-Sheue Tsai, Matthew J. Walter, David F. Wozniak, Alex S. Holehouse, John A. Tainer, William G. Fairbrother, Nima Mosammaparast
SummaryThe pre-mRNA life cycle requires intron processing; yet, how intron processing defects influence splicing and gene expression is unclear. Here, we find TTDN1, which is frequently mutated in non-photosensitive trichothiodystrophy (NP-TTD), func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0503367ec9efd5d220936eb37c95bca
https://doi.org/10.1101/2022.11.03.515106
https://doi.org/10.1101/2022.11.03.515106
Publikováno v:
Mol Cell
Although transcription is an essential cellular process, it is paradoxically also a well-recognized cause of genomic instability. R-loops, non-B DNA structures formed when nascent RNA hybridizes to DNA to displace the non-template strand as single-st
Autor:
Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird
Publikováno v:
Cancer Discovery
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179
Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a6f369ad5cbcb85ed2d339d7aa9050
https://cnrs.hal.science/hal-03759864/document
https://cnrs.hal.science/hal-03759864/document
Autor:
Alexandre G. Casanova, Li-Sheng Zhang, Ning Tsao, Brittany A. Townley, Nima Mosammaparast, Joshua R. Brickner, Chuan He, John A. Tainer, Rebecca Rodell, Tanveer Ahmad, Matthew D. Wood, Hua Sun, Jennifer M. Soll, Nicolas Reynoird, Clement Oyeniran, Alessandro Vindigni, Adit Ganguly, Albino Bacolla, Valentina Lukinović
Publikováno v:
Mol Cell
Molecular Cell
Molecular Cell, 2021, 81 (20), pp.4228-4242.e8. ⟨10.1016/j.molcel.2021.09.024⟩
Molecular Cell
Molecular Cell, 2021, 81 (20), pp.4228-4242.e8. ⟨10.1016/j.molcel.2021.09.024⟩
International audience; Summary Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the activation of the ASCC-ALKBH3 repair pathway is exquisitely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22341f9c122e9653e82bea7080278c0
https://europepmc.org/articles/PMC8931856/
https://europepmc.org/articles/PMC8931856/
Autor:
Derek J. Theisen, Wayne M. Yokoyama, Vivek Durai, Wandy L. Beatty, Nima Mosammaparast, Marco Gargaro, Herbert W. Virgin, William E. Gillanders, Robert D. Schreiber, Carlos G. Briseño, Qiuling Wang, Theresa L. Murphy, Joshua R. Brickner, Prachi Bagadia, L. David Sibley, Michael S. Diamond, Kenneth M. Murphy, Jesse T. Davidson, Pritesh Desai, Elvin J. Lauron
Publikováno v:
Science. 362:694-699
Adding to the cross-presentation family Immune responses to viral or tumor antigens are typically initiated by the process of cross-presentation. Cross-presentation is believed to be the major way that innate immune cells, such as the classical dendr
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging
Autor:
Su S. Maw, Miaw Sheue Tsai, Chenlin Song, Karlene A. Cimprich, Frédéric Chédin, Joshua R. Brickner, Magdalena P. Crossley, Su Mon Thin Zar
Publikováno v:
The Journal of cell biology. 220(9)
R-loops are three-stranded nucleic acid structures with both physiological and pathological roles in cells. R-loop imaging generally relies on detection of the RNA–DNA hybrid component of these structures using the S9.6 antibody. We show that the u