Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Joshua R Sanes"'
Publikováno v:
eLife, Vol 11 (2022)
The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types. We used single-cell RNA-seq to study how newly
Externí odkaz:
https://doaj.org/article/a10efda4c53b4e888c1b7ce1e26c7c78
Publikováno v:
eLife, Vol 10 (2021)
Retinal structure and function have been studied in many vertebrate orders, but molecular characterization has been largely confined to mammals. We used single-cell RNA sequencing (scRNA-seq) to generate a cell atlas of the chick retina. We identifie
Externí odkaz:
https://doaj.org/article/5d52fcabd5a84d0c90fcfa3f40e1b63a
Autor:
Joshua R Sanes
Publikováno v:
eLife, Vol 8 (2019)
Many authors start with the figures when writing a scientific paper, but it is easier to tell a good story if you start with the Introduction and the Results, and leave the figures to later.
Externí odkaz:
https://doaj.org/article/0caa941deb0d4482b9b45234a121e0ed
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180091 (2017)
The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bod
Externí odkaz:
https://doaj.org/article/9e2a43d6665444e3a77aac6e313e089b
Autor:
Kerry M Goodman, Masahito Yamagata, Xiangshu Jin, Seetha Mannepalli, Phinikoula S Katsamba, Göran Ahlsén, Alina P Sergeeva, Barry Honig, Joshua R Sanes, Lawrence Shapiro
Publikováno v:
eLife, Vol 5 (2016)
Sidekick (Sdk) 1 and 2 are related immunoglobulin superfamily cell adhesion proteins required for appropriate synaptic connections between specific subtypes of retinal neurons. Sdks mediate cell-cell adhesion with homophilic specificity that underlie
Externí odkaz:
https://doaj.org/article/e9bc2f0c2f4f4a988f06dcf96cc41409
Autor:
Maximilian Joesch, David Mankus, Masahito Yamagata, Ali Shahbazi, Richard Schalek, Adi Suissa-Peleg, Markus Meister, Jeff W Lichtman, Walter J Scheirer, Joshua R Sanes
Publikováno v:
eLife, Vol 5 (2016)
Resolving patterns of synaptic connectivity in neural circuits currently requires serial section electron microscopy. However, complete circuit reconstruction is prohibitively slow and may not be necessary for many purposes such as comparing neuronal
Externí odkaz:
https://doaj.org/article/1a7b7e801de74d13a4cf4f2b304eca2b
Autor:
Mu eQiao, Joshua R Sanes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2016)
Understanding how the nervous system functions requires mapping synaptic connections between neurons. Several methods are available for imaging neurons connected by chemical synapses, but few enable marking neurons connected by electrical synapses. H
Externí odkaz:
https://doaj.org/article/5cd5e75703194029b08423f2e57efda6
Autor:
Dimitar Kostadinov, Joshua R Sanes
Publikováno v:
eLife, Vol 4 (2015)
Dendritic and axonal arbors of many neuronal types exhibit self-avoidance, in which branches repel each other. In some cases, these neurites interact with those of neighboring neurons, a phenomenon called self/non-self discrimination. The functional
Externí odkaz:
https://doaj.org/article/8859c39571ff476980a08b9828861e89
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93140 (2014)
microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote maintenance and repair of the
Externí odkaz:
https://doaj.org/article/89a1de03883949659495c3deb5c9f05b
Autor:
Jin Li, Jongsu Choi, Xuesen Cheng, Justin Ma, Shahil Pema, Joshua R. Sanes, Graeme Mardon, Benjamin J. Frankfort, Nicholas M. Tran, Yumei Li, Rui Chen
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109916- (2024)
Summary: Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cellular heterogeneity by characterizing cell types across tissues and species. While several mouse retinal scRNA-seq datasets exist, each dataset is either limited in
Externí odkaz:
https://doaj.org/article/65d6d83bef1f49cd8b7fecbf3affb4c8